دورية أكاديمية
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Interplay of LncRNAs NEAT1 and TUG1 in Incidence of Cytokine Storm in Appraisal of COVID-19 Infection.

التفاصيل البيبلوغرافية
العنوان: Interplay of LncRNAs NEAT1 and TUG1 in Incidence of Cytokine Storm in Appraisal of COVID-19 Infection.
المؤلفون: Tayel SI; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University 32511, Shebin El-Kom, Egypt.; Medical Biochemistry Unit, College of Medicine, Al Baha University, Al Baha 65779, Saudi Arabia., El-Masry EA; Microbiology and Immunology Unit, Department of Pathology, College of Medicine, Jouf University, Sakaka 72388, Saudi Arabia.; Medical Microbiology and Immunology Department, Faculty of Medicine, Menoufia University, Shebin El Kom 32511, Egypt., Abdelaal GA; Chest Department, Faculty of Medicine, Menoufia University, Shebin El Kom 32511, Egypt., Shehab-Eldeen S; Tropical Medicine Department, Faculty of Medicine, Menoufia University, Shebin El Kom 32511, Egypt.; Internal Medicine Department, College of Medicine, King Faisal University, Al-Ahsaa 31982, Saudi Arabia., Essa A; Tropical Medicine Department, Faculty of Medicine, Menoufia University, Shebin El Kom 32511, Egypt.; Internal Medicine Department, College of Medicine, King Faisal University, Al-Ahsaa 31982, Saudi Arabia., Muharram NM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University 32511, Shebin El-Kom, Egypt.; Medical Biochemistry Unit, College of Medicine, Al Baha University, Al Baha 65779, Saudi Arabia.
المصدر: International journal of biological sciences [Int J Biol Sci] 2022 Jul 18; Vol. 18 (13), pp. 4901-4913. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lake Haven, N.S.W., Australia : Ivyspring International, c2004-
مواضيع طبية MeSH: COVID-19*/complications , Cytokine Release Syndrome*/genetics , Cytokine Release Syndrome*/virology , RNA, Long Noncoding*/genetics, Humans ; Incidence ; Interleukin-6 ; Tumor Necrosis Factor-alpha
مستخلص: Background : In 2019, the coronavirus pandemic emerged, resulting in the highest mortality and morbidity rate globally. It has a prevailing transmission rate and continues to be a global burden. There is a paucity of data regarding the role of long non-coding RNAs (lncRNAs) in COVID-19. Therefore, the current study aimed to investigate lncRNAs, particularly NEAT1 and TUG1, and their association with IL-6, CCL2, and TNF-α in COVID-19 patients with moderate and severe disease. Methods : The study was conducted on 80 COVID-19 patients (35 with severe and 45 with moderate infection) and 40 control subjects. Complete blood count (CBC), D-dimer assay, serum ferritin, and CRP were assayed. qRT-PCR was used to measure RNAs and lncRNAs. Results : NEAT1 and TUG1 expression levels were higher in COVID-19 patients compared with controls (P<0.001). Furthermore, CCL2, IL-6, and TNF-α expressions were higher in COVID-19 patients compared to controls (P<0.001). CCL2 and IL-6 expression levels were significantly higher in patients with severe compared to those with moderate COVID-19 infection (P<0.001). IL-6 had the highest accuracy in distinguishing COVID-19 patients (AUC=1, P<0.001 at a cutoff of 0.359), followed by TUG1 (AUC=0.999, P<0.001 at a cutoff of 2.28). NEAT1 and TUG1 had significant correlations with the measured cytokines, and based on the multivariate regression analysis, NEAT1 is the independent predictor for survival in COVID-19 patients (P=0.02). Conclusion : In COVID-19 patients, significant overexpression of NEAT1 and TUG1 was observed, consistent with cytokine storm. TUG1 could be an efficient diagnostic biomarker, whereas NEAT1 was an independent predictor for overall survival.
Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
(© The author(s).)
References: Open Forum Infect Dis. 2020 Sep 03;7(10):ofaa407. (PMID: 33123608)
JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570)
Noncoding RNA. 2021 Aug 31;7(3):. (PMID: 34564316)
Emerg Microbes Infect. 2020 Dec;9(1):761-770. (PMID: 32228226)
N Engl J Med. 2020 Dec 3;383(23):2255-2273. (PMID: 33264547)
Nat Rev Drug Discov. 2020 Oct;19(10):673-694. (PMID: 32782413)
J Cell Physiol. 2018 Sep;233(9):7103-7111. (PMID: 29633273)
Ann Rheum Dis. 2021 Jan;80(1):88-95. (PMID: 32978237)
Cell Mol Life Sci. 2016 Jul;73(13):2491-509. (PMID: 27007508)
World J Gastroenterol. 2013 Jun 21;19(23):3658-64. (PMID: 23801869)
Asian Pac J Cancer Prev. 2013;14(4):2311-5. (PMID: 23725133)
Cell. 2018 May 3;173(4):906-919.e13. (PMID: 29706547)
N Engl J Med. 2020 Feb 20;382(8):727-733. (PMID: 31978945)
Sci Rep. 2020 Jul 20;10(1):11954. (PMID: 32686726)
Nat Rev Immunol. 2018 Dec;18(12):773-789. (PMID: 30254251)
J Cell Mol Med. 2021 Jun;25(12):5823-5827. (PMID: 33969601)
Cardiovasc Pathol. 2018 Mar - Apr;33:6-15. (PMID: 29268138)
Lancet. 2020 May 2;395(10234):1407-1409. (PMID: 32278362)
Clin Infect Dis. 2020 Jul 28;71(15):762-768. (PMID: 32161940)
Genome Res. 2012 Sep;22(9):1775-89. (PMID: 22955988)
Cell Death Dis. 2014 May 22;5:e1243. (PMID: 24853421)
Immunotherapy. 2016 Jul;8(8):959-70. (PMID: 27381687)
Cells. 2020 Oct 29;9(11):. (PMID: 33138195)
Lancet Rheumatol. 2020 Aug;2(8):e474-e484. (PMID: 32835257)
EClinicalMedicine. 2020 Jun 20;24:100418. (PMID: 32766537)
Front Bioeng Biotechnol. 2021 Jan 15;8:582953. (PMID: 33520952)
Ann Rheum Dis. 2021 May;80(5):e62. (PMID: 32546603)
Mol Oral Microbiol. 2021 Dec;36(6):291-294. (PMID: 34463043)
Front Immunol. 2020 Jun 26;11:1580. (PMID: 32670297)
J Clin Invest. 2020 May 1;130(5):2202-2205. (PMID: 32217834)
Nat Rev Immunol. 2020 Jun;20(6):355-362. (PMID: 32376901)
Open Med (Wars). 2021 Jun 24;16(1):919-930. (PMID: 34222667)
Cytokine X. 2020 Jun;2(2):100029. (PMID: 32421092)
Signal Transduct Target Ther. 2020 Dec 24;5(1):294. (PMID: 33361761)
J Infect. 2020 Jun;80(6):607-613. (PMID: 32283152)
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975. (PMID: 32350134)
BMC Pulm Med. 2020 Feb 22;20(1):49. (PMID: 32087725)
Cell Rep. 2019 Jun 11;27(11):3295-3304.e4. (PMID: 31189112)
Front Immunol. 2020 May 01;11:827. (PMID: 32425950)
Int J Clin Exp Pathol. 2019 Aug 01;12(8):2837-2848. (PMID: 31934120)
Eur Rev Med Pharmacol Sci. 2018 Dec;22(24):8574-8581. (PMID: 30575896)
J Surg Oncol. 2013 Apr;107(5):555-9. (PMID: 22961206)
Sci China Life Sci. 2020 Mar;63(3):364-374. (PMID: 32048163)
J Pharmacol Sci. 2021 Feb;145(2):202-212. (PMID: 33451755)
Genes (Basel). 2020 Jul 07;11(7):. (PMID: 32646047)
JAMA Intern Med. 2020 Jul 1;180(7):934-943. (PMID: 32167524)
Clin Infect Dis. 2020 Sep 12;71(6):1400-1409. (PMID: 32270184)
Am J Respir Cell Mol Biol. 2016 Sep;55(3):309-22. (PMID: 27149613)
Lancet. 2020 Mar 28;395(10229):1033-1034. (PMID: 32192578)
Int J Infect Dis. 2020 Feb;91:264-266. (PMID: 31953166)
Mol Ther Nucleic Acids. 2014 Nov 18;3:e196. (PMID: 25405465)
Am J Respir Cell Mol Biol. 2007 Jul;37(1):121-8. (PMID: 17379849)
Int J Chron Obstruct Pulmon Dis. 2016 Nov 28;11:2951-2964. (PMID: 27932875)
PLoS One. 2022 Jan 10;17(1):e0261242. (PMID: 35007307)
J Med Virol. 2020 Apr;92(4):424-432. (PMID: 31981224)
Nat Rev Immunol. 2020 Jun;20(6):363-374. (PMID: 32346093)
Nat Med. 2020 Oct;26(10):1636-1643. (PMID: 32839624)
Antiviral Res. 2018 Jan;149:58-74. (PMID: 29128390)
Nat Commun. 2019 Apr 2;10(1):1495. (PMID: 30940803)
فهرسة مساهمة: Keywords: COVID-19; IL-6; NEAT1; TNF-α; TUG1
المشرفين على المادة: 0 (Interleukin-6)
0 (NEAT1 long non-coding RNA, human)
0 (RNA, Long Noncoding)
0 (TUG1 long noncoding RNA, human)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20220819 Date Completed: 20220822 Latest Revision: 20221012
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9379411
DOI: 10.7150/ijbs.72318
PMID: 35982898
قاعدة البيانات: MEDLINE
الوصف
تدمد:1449-2288
DOI:10.7150/ijbs.72318