دورية أكاديمية
Bystander LECT2 amyloidosis in tumor nephrectomy.
| العنوان: | Bystander LECT2 amyloidosis in tumor nephrectomy. |
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| المؤلفون: | Gallan AJ; Department of Pathology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA. agallan@mcw.edu., Bhasin-Chhabra B; Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA., Kilari D; Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Johnson S; Department of Urology, Medical College of Wisconsin, Milwaukee, WI, USA., D'Souza A; Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. |
| المصدر: | CEN case reports [CEN Case Rep] 2023 Feb; Vol. 12 (1), pp. 104-109. Date of Electronic Publication: 2022 Aug 20. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Japan Country of Publication: Japan NLM ID: 101636244 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-4449 (Electronic) Linking ISSN: 21924449 NLM ISO Abbreviation: CEN Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Springer Japan, [2012]- |
| مواضيع طبية MeSH: | Amyloidosis*/diagnosis , Amyloidosis*/pathology , Carcinoma, Renal Cell*/diagnosis , Carcinoma, Renal Cell*/surgery , Carcinoma, Renal Cell*/pathology , Kidney Neoplasms*/diagnosis , Kidney Neoplasms*/surgery , Kidney Neoplasms*/pathology, Humans ; Male ; Aged ; Kidney/pathology ; Nephrectomy ; Intercellular Signaling Peptides and Proteins/analysis |
| مستخلص: | Pathologic evaluation of the non-neoplastic renal parenchyma in tumor nephrectomy specimens is critical and can detect both renal-limited and systemic pathologies. We report the case of a 69-year-old Punjabi male who underwent cytoreductive nephrectomy for advanced renal cell carcinoma after immunotherapy. We detected clinically unexpected leukocyte chemotactic factor 2 (LECT2) amyloidosis during pathologic analysis of the surrounding non-neoplastic renal parenchyma, which was confirmed by mass spectrometry. LECT2 amyloidosis occurs predominantly in Hispanic patients and has only rarely been described in Punjabi patients. This case highlights the importance of careful pathologic evaluation of the non-neoplastic renal parenchyma of nephrectomy specimens and raises awareness that LECT2 amyloidosis can occur outside of the typical demographic of Hispanic patients. (© 2022. The Author(s) under exclusive licence to The Japan Society of Nephrology.) |
| References: | Clin J Am Soc Nephrol. 2015 Nov 6;10(11):2084-93. (PMID: 25873265) Amyloid. 2020 Dec;27(4):217-222. (PMID: 33100054) Arch Pathol Lab Med. 2009 Jul;133(7):1012-25. (PMID: 19642728) Am J Surg Pathol. 2007 Nov;31(11):1703-8. (PMID: 18059227) Am J Surg Pathol. 2006 May;30(5):575-84. (PMID: 16699311) Am J Surg Pathol. 2015 Apr;39(4):558-64. (PMID: 25602789) Mayo Clin Proc. 2000 Dec;75(12):1236-42. (PMID: 11126830) Amyloid. 2016 Jun;23(2):119-23. (PMID: 26912093) Am J Clin Pathol. 2021 Oct 13;156(5):913-919. (PMID: 34075420) Kidney Int. 2008 Jul;74(2):218-22. (PMID: 18449172) Cancer Treat Rev. 2017 Jul;58:70-76. (PMID: 28689073) Kidney Int. 2010 May;77(9):816-9. (PMID: 20182418) Kidney Int. 2012 Jul;82(2):226-34. (PMID: 22495291) Am J Kidney Dis. 2014 Nov;64(5):790-2. (PMID: 25064673) Mediterr J Hematol Infect Dis. 2015 Jul 01;7(1):e2015043. (PMID: 26185608) Nephrol Dial Transplant. 2018 Feb 1;33(2):241-247. (PMID: 29401357) Mod Pathol. 2016 Apr;29(4):416-20. (PMID: 26867784) Adv Anat Pathol. 2013 Nov;20(6):424-39. (PMID: 24113313) Indian J Nephrol. 2020 May-Jun;30(3):204-206. (PMID: 33013073) Kidney Int. 2014 Aug;86(2):370-7. (PMID: 24451324) Kidney Int. 2016 Sep;90(3):638-47. (PMID: 27282937) N Engl J Med. 2003 Aug 7;349(6):583-96. (PMID: 12904524) Am J Kidney Dis. 2019 Dec;74(6):853-856. (PMID: 31204194) Kidney Int. 2014 Aug;86(2):378-82. (PMID: 24522497) Annu Rev Pathol. 2017 Jan 24;12:277-304. (PMID: 27959636) |
| فهرسة مساهمة: | Keywords: Amyloidosis; LECT2; Nephrectomy; Onconephrology; Punjabi; Renal cell carcinoma; Renal pathology |
| المشرفين على المادة: | 0 (LECT2 protein, human) 0 (Intercellular Signaling Peptides and Proteins) |
| تواريخ الأحداث: | Date Created: 20220819 Date Completed: 20230203 Latest Revision: 20230322 |
| رمز التحديث: | 20230323 |
| مُعرف محوري في PubMed: | PMC9892383 |
| DOI: | 10.1007/s13730-022-00728-9 |
| PMID: | 35986199 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2192-4449 |
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| DOI: | 10.1007/s13730-022-00728-9 |