دورية أكاديمية
A secular trend in invasive non-typhoidal Salmonella in South India, 2000-2020: Identification challenges and antibiogram.
| العنوان: | A secular trend in invasive non-typhoidal Salmonella in South India, 2000-2020: Identification challenges and antibiogram. |
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| المؤلفون: | Jacob JJ; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Solaimalai D; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Rachel T; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Pragasam AK; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Sugumar S; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Jeslin P; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Anandan S; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address: vbalaji@cmcvellore.ac.in. |
| المصدر: | Indian journal of medical microbiology [Indian J Med Microbiol] 2022 Oct-Dec; Vol. 40 (4), pp. 536-540. Date of Electronic Publication: 2022 Aug 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8700903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-3646 (Electronic) Linking ISSN: 02550857 NLM ISO Abbreviation: Indian J Med Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New Delhi : Indian Association of Medical Microbiologists |
| مواضيع طبية MeSH: | Quinolones* , Salmonella Infections*/epidemiology , Typhoid Fever*, Adolescent ; Ampicillin ; Anti-Bacterial Agents/pharmacology ; Cephalosporins ; Chloramphenicol ; Humans ; India/epidemiology ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Salmonella/genetics ; Trimethoprim, Sulfamethoxazole Drug Combination |
| مستخلص: | Purpose: Invasive non-typhoidal Salmonella (iNTS) disease is an important cause of morbidity and mortality in African countries. However, the incidence in Indian subcontinent remains poorly documented. This study has assessed the incidence of iNTS in India with a perspective on its AMR profiles and serovar distribution for a period of 21 years from 2000 to 2020 from a tertiary care centre in South India. Methods: A total of 461 iNTS isolates were subjected to serotyping and antimicrobial susceptibility testing (AST). A subset of isolates was genotyped by multi locus sequence typing (MLST) and results were compared to serotyping to predict the accuracy. Results: Overall, 461 iNTS isolates were characterised mostly comprising of S. Typhimurium (49.2%) and S. Enteritidis (28.8%). Proportion of isolates resistant to first line antibiotics such as ampicillin, chloramphenicol and trimethoprim/sulphamethoxazole were 6.7%, 1.7% and 3.6% respectively. Isolates resistant to third generation cephalosporin are at a gradual rise while decreased susceptibility to quinolones was most common. The incidence of iNTS infection was maximum in the age group of >15 years. MLST analysis showed discrepancies in assigning the serovars by serotyping as three S. Saintpaul were identified as S. Typhimurium. Conclusion: The clinical epidemiology, serovar distribution and antimicrobial susceptibility patterns of invasive Salmonella isolates from India suggest that there is only a small burden of iNTS disease. However the gradual emergence of AMR in iNTS isolates indicates serious risk for public health warranting the importance enhanced molecular surveillance. Competing Interests: Conflict of interest The authors declare that there is no potential conflict of interest. (Copyright © 2022 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Multi drug resistance; Non-typhoidal Salmonella; Surveillance; iNTS |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Cephalosporins) 0 (Quinolones) 66974FR9Q1 (Chloramphenicol) 7C782967RD (Ampicillin) 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination) |
| تواريخ الأحداث: | Date Created: 20220820 Date Completed: 20221019 Latest Revision: 20221110 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijmmb.2022.07.015 |
| PMID: | 35987666 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1998-3646 |
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| DOI: | 10.1016/j.ijmmb.2022.07.015 |