دورية أكاديمية
Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.
| العنوان: | Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing. |
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| المؤلفون: | Liu X; First Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China., Qi Y; Department of Human Anatomy, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China., Zhao G; School of Rehabilitation Sciences, Gannan Medical University, Ganzhou 341000, China., Zhang Z; Department of Pathophysiology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China., Cao Y; First Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China., Li Y; Department of Forensic Medicine, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China., Xue J; Department of Pathophysiology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China. Electronic address: xjhua@gmu.edu.cn., Tang X; Department of Human Anatomy, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China. Electronic address: xltang25@gmu.edu.cn. |
| المصدر: | Neuroscience letters [Neurosci Lett] 2022 Sep 25; Vol. 788, pp. 136841. Date of Electronic Publication: 2022 Aug 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | MicroRNAs*/genetics , MicroRNAs*/metabolism , Parkinson Disease*/metabolism, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Humans ; Mesencephalon/metabolism ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/metabolism |
| مستخلص: | MPTP models have been developed to mimic human Parkinson's disease and serve as an indispensable tool for studying PD. Among them, subacute MPTP PD models are popular due to their short modeling period and similarity to PD pathology. However, the early pathophysiological mechanism of the model remains to be further clarified. More and more studies have shown that dysregulation of miRNAs plays an important role in the occurrence and development of neurodegenerative diseases, including PD. In this study, we identified 43 differentially expressed microRNAs (miRNAs) in the ventral midbrain of MPTP-induced subacute PD mouse by RNA sequencing. Further bioinformatics analysis revealed that these miRNAs were significantly enriched in axon guidance/neuron projection, metabolic pathways/cellular macromolecule metabolic process and PI3K/AKT signaling pathways, which were involved in the occurrence and development of early PD. Thus, targeted regulation of these miRNAs may reverse the neurodegeneration of early PD. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: MPTP; Parkinson’s disease; miRNAs |
| المشرفين على المادة: | 0 (MicroRNAs) 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) |
| تواريخ الأحداث: | Date Created: 20220821 Date Completed: 20220915 Latest Revision: 20220915 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neulet.2022.136841 |
| PMID: | 35988790 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7972 |
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| DOI: | 10.1016/j.neulet.2022.136841 |