دورية أكاديمية
أعرض في EDS

Effects of chronic hypoxia on the gene expression profile in the embryonic heart in three Chinese indigenous chicken breeds ( Gallus gallus ).

التفاصيل البيبلوغرافية
العنوان: Effects of chronic hypoxia on the gene expression profile in the embryonic heart in three Chinese indigenous chicken breeds ( Gallus gallus ).
المؤلفون: Li X; College of Animal Science, Anhui Science and Technology University, Fengyang, China., Abdel-Moneim AE; Biological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt., Hu Z; College of Animal Science, Anhui Science and Technology University, Fengyang, China., Mesalam NM; Biological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt., Yang B; College of Animal Science, Anhui Science and Technology University, Fengyang, China.
المصدر: Frontiers in veterinary science [Front Vet Sci] 2022 Aug 05; Vol. 9, pp. 942159. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Hypoxia exposure (HE) has adverse impacts on the embryonic development of chicken, whereas the mechanism underlying the response of the heart to HE during embryo development in birds is still unclear. Therefore, our study was designed to reveal the hub genes and the signaling pathways linked to chronic hypoxia stress. Thus, the gene expression microarray GSE12675, downloaded from the GEO database, included 12 embryonic heart samples in hypoxia and normoxia of three Chinese indigenous chicken breeds [Shouguang (SG), Tibetan (TB), and Dwarf Recessive White (DRW) chickens]. A total of 653 to 714 breed-specific differentially expressed genes (DEGs) were detected in each pairwise comparison. Gene ontology (GO) showed that the DEGs were mainly involved in biological processes, including vasoconstriction, cell differentiation, and the positive regulation of vasoconstriction. KEGG enrichment revealed that the DEGs were mainly enriched in MAPK, PPAR, insulin, adrenergic signaling in cardiomyocytes, etc. Moreover, 48 genes (e.g., SGCD, DHRS9, HELQ, MCMDC2 , and ESCO2 ) might contribute to the response of the heart to HE. Taken together, the current study provides important clues for understanding the molecular mechanism of the heart's response to HE during the embryonic period of chicken.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Li, Abdel-Moneim, Hu, Mesalam and Yang.)
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فهرسة مساهمة: Keywords: chicken; chronic hypoxia; embryonic heart; gene; signaling pathway
تواريخ الأحداث: Date Created: 20220822 Latest Revision: 20220823
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9390884
DOI: 10.3389/fvets.2022.942159
PMID: 35990266
قاعدة البيانات: MEDLINE
الوصف
تدمد:2297-1769
DOI:10.3389/fvets.2022.942159