دورية أكاديمية
Folate levels in children with sickle cell anaemia on folic acid supplementation in steady state and crises at a tertiary hospital in Enugu, Nigeria: a prospective, comparative study.
| العنوان: | Folate levels in children with sickle cell anaemia on folic acid supplementation in steady state and crises at a tertiary hospital in Enugu, Nigeria: a prospective, comparative study. |
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| المؤلفون: | Nnajekwu UC; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria., Nnajekwu CO; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria., Onukwuli VO; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria.; Department of Paediatrics, College Of Medicine, University Of Nigeria, Enugu Campus., Chukwu BF; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria.; Department of Paediatrics, College Of Medicine, University Of Nigeria, Enugu Campus., Ikefuna AN; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria.; Department of Paediatrics, College Of Medicine, University Of Nigeria, Enugu Campus., Emodi IJ; Department of Paediatrics, University Of Nigeria Teaching Hospital, Enugu, Nigeria.; Department of Paediatrics, College Of Medicine, University Of Nigeria, Enugu Campus. |
| المصدر: | Malawi medical journal : the journal of Medical Association of Malawi [Malawi Med J] 2022 Jun; Vol. 34 (2), pp. 132-137. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Montfort Press for the Medical Association of Malawi Country of Publication: Malawi NLM ID: 9500170 Publication Model: Print Cited Medium: Internet ISSN: 1995-7270 (Electronic) Linking ISSN: 19957262 NLM ISO Abbreviation: Malawi Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lilongwe, Malawi : Published by Montfort Press for the Medical Association of Malawi, [1990- |
| مواضيع طبية MeSH: | Anemia, Sickle Cell* , Folic Acid*, Child ; Dietary Supplements ; Humans ; Nigeria ; Prospective Studies ; Tertiary Care Centers |
| مستخلص: | Introduction: Folic acid supplementation is an integral aspect of the management of children with sickle cell anaemia (SCA) especially in Africa. In spite of this, there have been concerns about lower folate levels, especially during crisis. Aim: To determine red cell folate levels of children with sickle cell anaemia in steady state and during crisis and compare with those with haemoglobin AA genotype. Method: This study was prospective, hospital based, and comparative. Fifty children with sickle cell anaemia were recruited during crises and followed up until they met the criteria for attaining steady state. The controls were fifty children matched with those with SCA for age and gender and had haemoglobin AA genotype. Red cell folate estimation was done with the Electrochemiluminescence Immunoassay (ECLIA) method using the automated Roche Cobas e411 equipment. Results: The median (IQR) red cell folate level in children during sickle cell crisis was 265.95 (134.50) ng/ml, which was significantly lower than the median (IQR) of 376.30 (206.85) ng/ml obtained during steady state. Most children with SCA (41 out of 50) had significantly higher folate levels during steady state (T=1081, Z-score= -4.660, p < 0.001). Median level of red cell folate was lower during anaemic crisis compared to vaso-occlusive crisis, though not significantly so (N(50), U = 214.00, Z-score= -1.077, p = 0.305). The median red cell folate level of normal controls was 343.55 (92.90) ng/ml, which was significantly lower than the 376.30 (206.85) ng/ml obtained during steady state (N(50), U= 209.00, Z-score= -7.177, p <0.001). Conclusion: Median red cell folate levels of the study participants were within normal limits, though most children with SCA had significantly higher levels during steady state compared to crisis. Normal controls had significantly lower red cell folate levels than the children with SCA during steady state. (© 2022 The College of Medicine and the Medical Association of Malawi.) |
| References: | Scand J Haematol. 1975 Mar;14(1):71-9. (PMID: 1121649) East Afr Med J. 1962 May;39:213-21. (PMID: 14005324) P T. 2008 Apr;33(4):238-43. (PMID: 19750169) Am J Hematol. 2012 Mar;87(3):338. (PMID: 22190068) J Pediatr Hematol Oncol. 2001 Mar-Apr;23(3):165-9. (PMID: 11305720) Am J Dis Child. 1974 Mar;127(3):389-93. (PMID: 4814883) N Engl J Med. 2003 May 29;348(22):2204-7. (PMID: 12773647) Lancet. 2010 Dec 11;376(9757):2018-31. (PMID: 21131035) BMC Res Notes. 2012 Aug 01;5:396. (PMID: 22849350) Anemia. 2015;2015:791498. (PMID: 25667774) Cochrane Database Syst Rev. 2018 Mar 16;3:CD011130. (PMID: 29546732) |
| فهرسة مساهمة: | Keywords: Red cell folate; crises; sickle cell anaemia; steady state |
| المشرفين على المادة: | 935E97BOY8 (Folic Acid) |
| تواريخ الأحداث: | Date Created: 20220822 Date Completed: 20220823 Latest Revision: 20220824 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9356529 |
| DOI: | 10.4314/mmj.v34i2.9 |
| PMID: | 35991819 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1995-7270 |
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| DOI: | 10.4314/mmj.v34i2.9 |