دورية أكاديمية
Royal jelly reduce DNA damage induced by alkylating agent in mice.
| العنوان: | Royal jelly reduce DNA damage induced by alkylating agent in mice. |
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| المؤلفون: | Damiani AP; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Magenis ML; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Dagostin LS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Beretta ÂCDL; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Sarter RJ; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Longaretti LM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Monteiro IO; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Andrade VM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil. Electronic address: vmoraesdeandrade@yahoo.com.br. |
| المصدر: | Mutation research [Mutat Res] 2022 Jul-Dec; Vol. 825, pp. 111796. Date of Electronic Publication: 2022 Aug 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0400763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-135X (Electronic) Linking ISSN: 00275107 NLM ISO Abbreviation: Mutat Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, [1964- |
| مواضيع طبية MeSH: | Alkylating Agents*/toxicity , DNA Damage*, Mice ; Bees ; Animals ; Fatty Acids/pharmacology ; Comet Assay ; Methyl Methanesulfonate/toxicity ; Mutagens/toxicity |
| مستخلص: | Royal jelly (RJ) is a creamy white-yellow liquid that is secreted by the mandibular and hypopharyngeal glands of bees to nourish the larvae. RJ has gained increasing interest in recent years owing to its antioxidant potential. However, little is known about adequate RJ dosing and its effects on genetic material. Thus, the aim of this study was to evaluate the in vivo effects of RJ on genotoxicity and mutagenicity induced by the alkylating agent methyl methanesulfonate (MMS). In this study, 3-month-old Swiss albino male mice (N = 66) were divided into 11 groups for experimentation. Experiments were performed by administering lyophilized RJ (150 mg/kg, 300 mg/kg, and 1000 mg/kg) or water via gavage as pre- and posttreatment processes with the alkylating agent MMS. After treatment, blood samples were collected from the mice via an incision at the end of the tail to conduct comet assays at times of 24 h and 48 h posttreatment. The mice were then euthanized to remove the bone marrow for a micronucleus test. Overall, regardless of dose, RJ did not exhibit genotoxic, mutagenic activity and the administration of high doses, mainly in the form of posttreatment, presented antigenotoxic and antimutagenic actions. Further, a dose-response correlation was observed in the RJ posttreatment groups. These results demonstrate that RJ administration was effective in reversing the damage caused by the alkylating agent MMS. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Genotoxicity; Posttreatment; Pretreatment; Royal jelly |
| المشرفين على المادة: | L497I37F0C (royal jelly) 0 (Alkylating Agents) 0 (Fatty Acids) AT5C31J09G (Methyl Methanesulfonate) 0 (Mutagens) |
| تواريخ الأحداث: | Date Created: 20220825 Date Completed: 20221206 Latest Revision: 20221216 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.mrfmmm.2022.111796 |
| PMID: | 36007462 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-135X |
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| DOI: | 10.1016/j.mrfmmm.2022.111796 |