دورية أكاديمية
Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology.
| العنوان: | Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology. |
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| المؤلفون: | Cai Q; Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Costa DN; Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Metter CK; Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Goldberg K; Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Roehrborn CG; Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Cadeddu J; Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Pedrosa I; Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Meng X; Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Mostardeiro TR; Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390., Shah RB; Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390. Electronic address: Rajal.Shah@UTSouthwestern.edu. |
| المصدر: | Urologic oncology [Urol Oncol] 2022 Oct; Vol. 40 (10), pp. 452.e1-452.e8. Date of Electronic Publication: 2022 Aug 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9805460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2496 (Electronic) Linking ISSN: 10781439 NLM ISO Abbreviation: Urol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Philadelphia, PA : Elsevier Original Publication: New York, NY : Elsevier Science, |
| مواضيع طبية MeSH: | Carcinoma, Intraductal, Noninfiltrating*/pathology , Multiparametric Magnetic Resonance Imaging* , Prostatic Neoplasms*/diagnostic imaging , Prostatic Neoplasms*/surgery, Biopsy ; Humans ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging/methods ; Male ; Neoplasm Grading ; Retrospective Studies |
| مستخلص: | Purpose: Accurate preoperative detection of prostate cancer (PCa) exhibiting "cribriform" morphology (intraductal carcinoma [IDC-P] or cribriform Gleason pattern 4 [CrP4]) is important as it is independently associated with a variety of adverse clinical outcomes. The sensitivity of multiparametric magnetic resonance imaging (mpMRI) in the detection of PCa exhibiting "cribriform" morphology remains controversial. Materials and Methods: A total of 117 eligible men with prospectively reported mpMRI who underwent in-bore MRI targeted biopsy followed by whole-mount radical prostatectomy (RP) were analyzed for lesion-level imaging-pathology correlation. Results: Of the 206 PCa foci at RP (117 index and 89 non-index), 74% (152/206) were detected by mpMRI. Of the 54 tumors missed by mpMRI, most were non-index (98%, 53/54), grade group (GG) 1 (68%, 37/54) or GG 2 (26%, 14/54), with a median size of 1.0 cm (range, 0.7-1.5 cm), and non-cribriform morphology (96%, 52/54). Cribriform morphology was detected in 26% (53/206) of all tumors, and although targeted biopsies identified 96% (51/53) of these cancers, the cribriform component was depicted in only 45% (24/53). Of these, mpMRI detected all (100%, 44/44) index and 78% (7/9) of the non-index tumors. At univariable analysis, tumor size greater than 5 mm, % pattern 4 > 5%, cribriform morphology, zone (transition versus peripheral zone), and region (apex versus mid/base) were significantly associated with tumor visibility at mpMRI. At multivariable analysis, only tumor size, presence of any pattern 4, and peripheral zone remained significant predictors for visibility by mpMRI. Conclusion: At a lesion level, mpMRI offers high sensitivity for the detection of cribriform morphologies, however, the cribriform component is frequently missed by targeted biopsies. The MRI visibility is significantly associated with larger tumor size, presence of Gleason pattern 4, and peripheral zone location. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cribriform pattern 4; Intraductal carcinoma; Multiparametric magnetic resonance Imaging; Prostate adenocarcinoma; Targeted biopsy |
| تواريخ الأحداث: | Date Created: 20220825 Date Completed: 20220928 Latest Revision: 20221025 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.urolonc.2022.07.012 |
| PMID: | 36008255 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2496 |
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| DOI: | 10.1016/j.urolonc.2022.07.012 |