دورية أكاديمية
أعرض في EDS

Singular and Combined Effects of Essential Oil and Honey of Eucalyptus Globulus on Anti-Inflammatory, Antioxidant, Dermatoprotective, and Antimicrobial Properties: In Vitro and In Vivo Findings.

التفاصيل البيبلوغرافية
العنوان: Singular and Combined Effects of Essential Oil and Honey of Eucalyptus Globulus on Anti-Inflammatory, Antioxidant, Dermatoprotective, and Antimicrobial Properties: In Vitro and In Vivo Findings.
المؤلفون: Assaggaf HM; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Naceiri Mrabti H; Laboratory of Pharmacology and Toxicology, Bio Pharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat BP 6203, Morocco., Rajab BS; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Attar AA; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Hamed M; Department of Pathology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Sheikh RA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Omari NE; Laboratory of Histology, Embryology, and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat BP 6203, Morocco., Menyiy NE; Laboratory of Pharmacology, National Agency of Medicinal and Aromatic Plants, Taouanate 34025, Morocco., Belmehdi O; Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek-Essaadi University, Tetouan 93000, Morocco., Mahmud S; Division of Cancer and Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Alshahrani MM; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran 61441, Saudi Arabia., Park MN; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea., Kim B; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea., Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey., Bouyahya A; Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat BP 6203, Morocco.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 11; Vol. 27 (16). Date of Electronic Publication: 2022 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Anti-Infective Agents*/pharmacology , Eucalyptus*/chemistry , Honey* , Oils, Volatile*/chemistry , Oils, Volatile*/pharmacology, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Arachidonate 5-Lipoxygenase ; Microbial Sensitivity Tests ; Monophenol Monooxygenase ; Plant Extracts/chemistry
مستخلص: Eucalyptus globulus is a plant widely used by the world population, including Morocco, in the treatment of several pathologies. The aim of this work is to evaluate the antioxidant, anti-inflammatory, dermatoprotective, and antimicrobial effects of essential oil and honey from E. globulus, as well as their combination. Chemical composition was determined by GC-MS analysis. The antioxidant activity was evaluated by three tests, namely, DPPH, reducing power, and the β-carotene/linoleic acid assay. The anti-inflammatory activity was investigated in vitro (5-lipoxygenase inhibition) and in vivo (carrageenan-induced paw edema model), while the dermatoprotective activity was tested in vitro (tyrosinase inhibition). Moreover, the antibacterial activity was assessed using agar well diffusion and microdilution methods. The results showed that eucalyptol presents the main compound of the essential oil of E. globulus (90.14%). The mixture of essential oil with honey showed the best antioxidant effects for all the tests used (0.07 < IC50 < 0.19 mg/mL), while the essential oil was the most active against tyrosinase (IC50 = 38.21 ± 0.13 μg/mL) and 5-lipoxygenase (IC50 = 0.88 ± 0.01 μg/mL), which corroborated the in vivo test. Additionally, the essential oil showed the best bactericidal effects against all strains tested, with inhibition diameter values ranging from 12.8 to 21.6 mm. The findings of this work showed that the combination of the essential oil with honey showed important results in terms of biological activity, but the determination of the underlying mechanisms of action remains a major prospect to be determined.
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فهرسة مساهمة: Keywords: Eucalyptus globulus; anti-inflammatory; antimicrobial; essential oils; honey
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Oils, Volatile)
0 (Plant Extracts)
EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
EC 1.14.18.1 (Monophenol Monooxygenase)
تواريخ الأحداث: Date Created: 20220826 Date Completed: 20220829 Latest Revision: 20230308
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9415335
DOI: 10.3390/molecules27165121
PMID: 36014359
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27165121