دورية أكاديمية
أعرض في EDS

Accelerating Effect of Cucurbita pepo L. Fruit Extract on Excisional Wound Healing in Depressed Rats Is Mediated through Its Anti-Inflammatory and Antioxidant Effects.

التفاصيل البيبلوغرافية
العنوان: Accelerating Effect of Cucurbita pepo L. Fruit Extract on Excisional Wound Healing in Depressed Rats Is Mediated through Its Anti-Inflammatory and Antioxidant Effects.
المؤلفون: Almohaimeed HM; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Al-Zahrani MH; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Almuhayawi MS; Department of Medical Microbiology & Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Yousef Abdullatif Jameel Chair of Prophetic Medicine Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Algaidi SA; Department of Anatomy, Taibah University, Medina 42353, Saudi Arabia., Batawi AH; Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Baz HA; Clinical Toxicology, Faculty of Medicine, Umm Al Qura University/King Abdullah Medical City, Mecca 24211, Saudi Arabia., Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia., Baz NA; Department of Periodontist, King Abdullah Medical City, Mecca 24211, Saudi Arabia., Saleh FM; Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia., Ayuob N; Department of Medical Histology, Faculty of Medicine, Damietta University, Damietta 34517, Egypt.
المصدر: Nutrients [Nutrients] 2022 Aug 15; Vol. 14 (16). Date of Electronic Publication: 2022 Aug 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Antioxidants*/metabolism , Cucurbita*, Rats ; Anti-Inflammatory Agents/pharmacology ; Corticosterone ; Cytokines/genetics ; Cytokines/metabolism ; Fruit/metabolism ; Plant Extracts/pharmacology ; Wound Healing ; Animals
مستخلص: Background: Chronic stress can hinder wound healing as it suppresses both the cellular and innate immune responses. Objectives: The study aims to assess the effectiveness of the administration of topical and oral Cucurbita pepo L. (CP) ethanolic extract in prompting excisional wound healing in rats exposed to chronic stress, and to explain how it works. Materials and methods: Fifty albino rats assigned to five groups (n = 10) were utilized in this study. The chronic unpredictable mild stress (CUMS) model was used for 4 weeks to induce depressive-like behavior in rats, and a forced swim test and corticosterone were assessed to confirm its occurrence. During the experiment, an excisional wound was induced in the rats and followed. Oxidant/antioxidants status and pro-inflammatory cytokines levels were measured in the serum and wound area. Gene expression of pro-inflammatory cytokines was also assessed using RT-PCR. Wound closure histopathological changes and immunohistochemical expression of CD68, CD3, and CD4 at the wound area was assessed. Results: The administration of CP, both orally and topically, significantly reduced (p < 0.001) the depressive-like behavior and corticosterone and pro-inflammatory cytokines levels, while it significantly up-regulated the antioxidant activity compared to the untreated and topically CP-treated groups. Both topically CP-treated and combined CP-treated groups showed complete re-epithelialization, reduced inflammatory cells infiltration, collagen fibers deposition, and significantly increased CD3, CD4 positive T cells count, with a superior effect in the combined CP-treated groups. Conclusion: Cucurbita pepo L., administrated both topically and orally, can enhance the wound healing process in rats with depressive-like behavior mostly through the antioxidant, anti-inflammatory, and antidepressant activities observed in this study.
References: Pharm Biol. 2016;54(4):581-7. (PMID: 26186459)
Adv Pharmacol Pharm Sci. 2021 Sep 15;2021:6697174. (PMID: 34568828)
Adv Skin Wound Care. 2007 Mar;20(3):157-65. (PMID: 17473722)
Molecules. 2012 Oct 09;17(10):11864-76. (PMID: 23047485)
Front Pharmacol. 2021 Nov 10;12:749766. (PMID: 34867356)
Evid Based Complement Alternat Med. 2008 Mar;5(1):95-101. (PMID: 18317555)
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16136-41. (PMID: 25331895)
J Psychosom Res. 2002 Oct;53(4):873-6. (PMID: 12377296)
Am J Clin Dermatol. 2013 Dec;14(6):449-59. (PMID: 24062083)
Front Psychiatry. 2020 Sep 11;11:569711. (PMID: 33061923)
Int J Low Extrem Wounds. 2022 Feb 1;:15347346221077571. (PMID: 35102769)
Oxid Med Cell Longev. 2020 Jul 20;2020:3295831. (PMID: 32774669)
Cell Biochem Funct. 2008 Mar-Apr;26(2):197-204. (PMID: 17918246)
Neurobiol Stress. 2016 Aug 24;6:78-93. (PMID: 28229111)
Neurochem Int. 2015 Nov;90:224-31. (PMID: 26386393)
Acta Psychiatr Scand. 2017 May;135(5):373-387. (PMID: 28122130)
Mediators Inflamm. 2012;2012:732902. (PMID: 23326020)
J Ethnopharmacol. 2010 Feb 3;127(2):468-77. (PMID: 19833187)
EMBO Rep. 2002 Jun;3(6):575-82. (PMID: 12034758)
Adv Wound Care (New Rochelle). 2016 May 1;5(5):208-229. (PMID: 27134765)
J Biochem Mol Toxicol. 2016 Feb;30(2):80-90. (PMID: 26459835)
J Neuroimmunol. 2002 Aug;129(1-2):74-83. (PMID: 12161023)
Neuron. 2020 Jul 22;107(2):234-256. (PMID: 32553197)
New Phytol. 2020 Jun;226(5):1240-1255. (PMID: 31230355)
J Hand Microsurg. 2015 Dec;7(2):294-9. (PMID: 26578832)
Wound Repair Regen. 2014 Jul-Aug;22(4):537-47. (PMID: 25041622)
Brain Behav Immun. 2005 May;19(3):217-22. (PMID: 15797310)
Front Pharmacol. 2021 May 10;12:663417. (PMID: 34040528)
Lipids Health Dis. 2016 Apr 11;15:73. (PMID: 27068642)
Life Sci. 2016 May 15;153:82-92. (PMID: 27091651)
J Ethnopharmacol. 2011 Feb 16;133(3):1027-32. (PMID: 21094239)
Periodontol 2000. 2021 Oct;87(1):94-106. (PMID: 34463997)
Br J Pharmacol. 2015 Jul;172(13):3353-69. (PMID: 25802070)
Brain Behav Immun. 2011 Feb;25(2):221-9. (PMID: 20955778)
Psychosom Med. 2003 Jan-Feb;65(1):92-9. (PMID: 12554820)
J Vis Exp. 2015 Mar 02;(97):. (PMID: 25867960)
PLoS One. 2015 Jun 09;10(6):e0128439. (PMID: 26057238)
Psychoneuroendocrinology. 2004 Sep;29(8):1004-11. (PMID: 15219651)
Compend Contin Educ Dent. 2018 Oct;39(9):608-612; quiz 613. (PMID: 30299110)
Brain Res. 2018 Apr 15;1685:19-28. (PMID: 29428597)
Iran J Basic Med Sci. 2017 Jul;20(7):798-805. (PMID: 28852445)
Nutr Res Rev. 2010 Dec;23(2):184-90. (PMID: 21110905)
Life Sci. 2016 Feb 15;147:39-45. (PMID: 26820672)
Int Immunopharmacol. 2014 Jun;20(2):322-30. (PMID: 24675438)
Int J Mol Sci. 2018 Jun 29;19(7):. (PMID: 29966221)
Molecules. 2019 May 14;24(10):. (PMID: 31091784)
Physiol Rev. 2003 Jul;83(3):835-70. (PMID: 12843410)
J Ethnopharmacol. 2014 Oct 28;156:16-25. (PMID: 25152298)
معلومات مُعتمدة: PNURSP2022R213 Princess Nourah bint Abdulrahman University
فهرسة مساهمة: Keywords: anti-inflammatory; antidepressant; antioxidants; cytokines; depression; healing; pro-inflammatory; wound
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
W980KJ009P (Corticosterone)
0 (Cytokines)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20220826 Date Completed: 20230719 Latest Revision: 20231105
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9415108
DOI: 10.3390/nu14163336
PMID: 36014842
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14163336