دورية أكاديمية
Association between Legume Consumption and Risk of Hypertension in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Cohort.
العنوان: | Association between Legume Consumption and Risk of Hypertension in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Cohort. |
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المؤلفون: | Hartley M; Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK., Fyfe CL; The Rowett Institute, University of Aberdeen, Ashgrove Road West, Aberdeen AB25 2ZD, UK., Wareham NJ; MRC Epidemiology Unit, Cambridge CB2 9SL, UK., Khaw KT; Clinical Gerontology Unit, Department of Public Health and Primary Care, Gonville and Caius College, Cambridge CB2 1TA, UK., Johnstone AM; The Rowett Institute, University of Aberdeen, Ashgrove Road West, Aberdeen AB25 2ZD, UK., Myint PK; Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK.; Aberdeen Cardiovascular & Diabetes Centre, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. |
المصدر: | Nutrients [Nutrients] 2022 Aug 16; Vol. 14 (16). Date of Electronic Publication: 2022 Aug 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Fabaceae* , Hypertension*/epidemiology , Hypertension*/etiology , Hypertension*/prevention & control , Neoplasms*, Aged ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Vegetables |
مستخلص: | Hypertension is a significant and preventable cardiovascular disease risk factor. Growing evidence suggests legumes have blood-pressure (BP) lowering properties. However, there is little population-based research on legume intake and hypertension risk in Western populations. The objective was to investigate the relationship between legume intake and blood pressure by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk cohort. Further, to identify any potential legume intake that confers benefits in relation to blood pressure. We included participants who completed both 7-day food diaries to assess legume intake and undertook a first (1993−1997) and second (1998−2000) health check from the EPIC-Norfolk prospective study. Legume consumption was categorized using percentile cut off values. We used multivariate logistic regression models to calculate the odds ratio of hypertension (defined as >140 mmHg systolic and/or >90 mmHg diastolic blood pressure) at the second health check, stratified by legume intake, adjusting for antihypertensive medication use and demographic, socioeconomic and lifestyle covariates. A total of 7522 participants were included with mean age (± SD) of 58.0 ± 8.9 years. The follow-up time was 3.7 years (range: 2.1−6.6 years). Mean legume consumption was 17.3 ± 16.3 g/day. Participants in the 97th percentile of legume intake had the lowest odds of subsequent hypertension (OR: 0.71; 95% CI: 0.52, 0.96). Legume consumption between 55−70 g/day was associated with reduced odds of hypertension (OR: 0.57; 95% CI: 0.37, 0.88); sex-specific values for men and women were 0.64 (0.38, 1.03) and 0.32 (0.12, 0.88), respectively. In this UK population, legume intake of 55−70 g/day was associated with a lower subsequent risk of hypertension. Given the low legume intake in the UK and Western countries, dietary guidance to increase intake above 55 g/day may lower the burden of hypertension and associated diseases. |
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معلومات مُعتمدة: | MC_UU_00006/1 United Kingdom MRC_ Medical Research Council; MC_UU_12015/1 United Kingdom MRC_ Medical Research Council; G0401527 United Kingdom MRC_ Medical Research Council; G1000143 United Kingdom MRC_ Medical Research Council; 14136 United Kingdom CRUK_ Cancer Research UK; MR/N003284/1 United Kingdom MRC_ Medical Research Council; MC_PC_13048 United Kingdom MRC_ Medical Research Council; (MR/N003284/1 and MC-UU_12015/1) United Kingdom MRC_ Medical Research Council; Grant number (C864/A14136). United Kingdom CRUK_ Cancer Research UK |
فهرسة مساهمة: | Keywords: blood pressure; cardiovascular disease; hypertension; legumes; plant-based; protein |
تواريخ الأحداث: | Date Created: 20220826 Date Completed: 20220829 Latest Revision: 20230705 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9415844 |
DOI: | 10.3390/nu14163363 |
PMID: | 36014869 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu14163363 |