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Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease.
المؤلفون: Veréb D; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kovács MA; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Antal S; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kocsis K; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Szabó N; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kincses B; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany., Bozsik B; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Faragó P; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Tóth E; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Király A; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Klivényi P; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Zádori D; Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary., Kincses ZT; Department of Radiology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
المصدر: Frontiers in neurology [Front Neurol] 2022 Aug 09; Vol. 13, pp. 927481. Date of Electronic Publication: 2022 Aug 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation, 2010]-
مستخلص: Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connectivity in the visual cortex is translative in nature or disrupted attentional modulation also contributes. In this study, we investigate functional connectivity modulation during a visuospatial attention task in patients with PD. In total, 15 PD and 16 age-matched healthy controls performed a visuospatial attention task while undergoing fMRI, in addition to a resting-state fMRI scan. Tensorial independent component analysis was used to investigate task-related network activity patterns. Independently, an atlas-based connectivity modulation analysis was performed using the task potency method. Spearman's rank correlation was calculated between task-related network expression, connectivity modulation, and clinical characteristics. Task-related networks including mostly visual, parietal, and prefrontal cortices were expressed to a significantly lesser degree in patients with PD ( p < 0.027). Resting-state functional connectivity did not differ between the healthy and diseased cohorts. Connectivity between the precuneus and ventromedial prefrontal cortex was modulated to a higher degree in patients with PD ( p < 0.004), while connections between the posterior parietal cortex and primary visual cortex, and also the superior frontal gyrus and opercular cortex were modulated to a lesser degree ( p < 0.001 and p < 0.011). Task-related network expression and superior frontal gyrus-opercular cortex connectivity modulation were significantly associated with UPDRSIII motor scores and the Hoehn-Yahr stages ( R = -0.72, p < 0.006 and R = -0.90, p < 0.001; R = -0.68, p < 0.01 and R = -0.71, p < 0.007). Task-related networks function differently in patients with PD in association with motor symptoms, whereas impaired modulation of visual and default-mode network connectivity was not correlated with motor function.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Veréb, Kovács, Antal, Kocsis, Szabó, Kincses, Bozsik, Faragó, Tóth, Király, Klivényi, Zádori and Kincses.)
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فهرسة مساهمة: Keywords: Parkinson's disease; attention; fMRI; functional connectivity; visual cortex
تواريخ الأحداث: Date Created: 20220826 Latest Revision: 20220827
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9396258
DOI: 10.3389/fneur.2022.927481
PMID: 36016543
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2295
DOI:10.3389/fneur.2022.927481