Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

التفاصيل البيبلوغرافية
العنوان:	Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.
المؤلفون:	Pavlisko EN; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA., Neely ML; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA., Kopetskie H; Rho, Durham, North Carolina, USA., Hwang DM; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; University Health Network, University of Toronto, Toronto, Ontario, Canada., Farver CF; Cleveland Clinic, Cleveland, Ohio, USA., Wallace WD; University of Southern California, Los Angeles, California, USA.; University of California Los Angeles, Los Angeles, California, USA., Arrossi A; Cleveland Clinic, Cleveland, Ohio, USA., Illei P; Johns Hopkins University, Baltimore, Maryland, USA., Sever ML; Rho, Durham, North Carolina, USA.; PPD Government and Public Health Services, Morrisville, North Carolina, USA., Kirchner J; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA., Frankel CW; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Snyder LD; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA.; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Martinu T; University Health Network, University of Toronto, Toronto, Ontario, Canada., Shino MY; University of California Los Angeles, Los Angeles, California, USA., Zaffiri L; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Williams N; National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA., Robien MA; National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA., Singer LG; University Health Network, University of Toronto, Toronto, Ontario, Canada., Budev M; Cleveland Clinic, Cleveland, Ohio, USA., Tsuang W; Cleveland Clinic, Cleveland, Ohio, USA., Shah PD; Johns Hopkins University, Baltimore, Maryland, USA., Reynolds JM; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Weigt SS; University of California Los Angeles, Los Angeles, California, USA., Belperio JA; University of California Los Angeles, Los Angeles, California, USA., Palmer SM; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA.; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Todd JL; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA.; Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
المصدر:	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Dec; Vol. 22 (12), pp. 3002-3011. Date of Electronic Publication: 2022 Sep 12.
نوع المنشور:	Multicenter Study; Journal Article; Research Support, N.I.H., Extramural
اللغة:	English
بيانات الدورية:	Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2023- : [New York] : Elsevier Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
مواضيع طبية MeSH:	Lung Transplantation/adverse effects , Acute Lung Injury/etiology , Acute Lung Injury/pathology , Pneumonia/epidemiology , Pneumonia/etiology , Pneumonia/pathology, Adult ; Humans ; Prospective Studies ; Prognosis ; Retrospective Studies ; Lung ; Risk Factors ; Cohort Studies
مستخلص:	We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of ALI/OP. We analyzed prospective, histologic diagnoses of ALI and OP in 4786 lung biopsies from 803 adult lung recipients. Univariable Cox regression was used to evaluate the impact of early (≤90 days) or late (>90 days) posttransplant ALI or OP on risk for chronic lung allograft dysfunction (CLAD) or death/retransplantation. These analyses demonstrated late ALI/OP conferred a two- to threefold increase in the hazards of CLAD or death/retransplantation; there was no association between early ALI/OP and these outcomes. To determine risk factors for late ALI/OP, we used univariable Cox models considering donor/recipient characteristics and posttransplant events as candidate risks. Grade 3 primary graft dysfunction, higher degree of donor/recipient human leukocyte antigen mismatch, bacterial or viral respiratory infection, and an early ALI/OP event were significantly associated with increased late ALI/OP risk. These data from a contemporary, multicenter cohort underscore the prognostic implications of ALI/OP on lung recipient outcomes, clarify the importance of the timing of these events, and identify clinical risks to target for ALI/OP prevention. (© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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معلومات مُعتمدة:	K23 HL138256 United States HL NHLBI NIH HHS; U01 AI113315 United States AI NIAID NIH HHS; UM2 AI117870 United States AI NIAID NIH HHS; UM2AI117870 United States NH NIH HHS
فهرسة مساهمة:	Keywords: acute lung injury; lung transplantation; organizing pneumonia
تواريخ الأحداث:	Date Created: 20220829 Date Completed: 20221205 Latest Revision: 20231118
رمز التحديث:	20240829
مُعرف محوري في PubMed:	PMC9925227
DOI:	10.1111/ajt.17183
PMID:	36031951
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1600-6143
DOI:	10.1111/ajt.17183