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Prognostic significance of CNSL at diagnosis of childhood B-cell acute lymphoblastic leukemia: A report from the South China Children's Leukemia Group.

التفاصيل البيبلوغرافية
العنوان: Prognostic significance of CNSL at diagnosis of childhood B-cell acute lymphoblastic leukemia: A report from the South China Children's Leukemia Group.
المؤلفون: Xu LH; Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Geng X; Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Liao N; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Yang LH; Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Mai HR; Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China., Wan WQ; Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, China., Huang LB; Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Zheng MC; Department of Hematology, Hunan Children's Hospital, Changsha, China., Tian C; Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Chen HQ; Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Chen QW; Department of Pediatrics, The First Affiliated Hospital of Nanchang University, Nanchang, China., Long XJ; Department of Pediatrics, Liuzhou People's Hospital, Liuzhou, China., Zhen ZJ; Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu RY; Department of Pediatrics, Huizhou Central People's Hospital, Huizhou, China., Li QR; Department of Pediatrics, Zhongshan People's Hospital, Zhongshan, China., Wu BY; Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, China., Wang LN; Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou, China., Kong XL; Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China., Chen GH; Department of Pediatrics, Huizhou First People's Hospital, Huizhou, China., Fang JP; Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Li Y; Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
المصدر: Frontiers in oncology [Front Oncol] 2022 Aug 10; Vol. 12, pp. 943761. Date of Electronic Publication: 2022 Aug 10 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: Objectives: The prognostic significance of acute lymphoblastic leukemia (ALL) patients with central nervous system leukemia (CNSL) at diagnosis is controversial. We aimed to determine the impact of CNSL at diagnosis on the clinical outcomes of childhood B-cell ALL in the South China Children's Leukemia Group (SCCLG).
Methods: A total of 1,872 childhood patients were recruited for the study between October 2016 and July 2021. The diagnosis of CNSL depends on primary cytological examination of cerebrospinal fluid, clinical manifestations, and imaging manifestations. Patients with CNSL at diagnosis received two additional courses of intrathecal triple injections during induction.
Results: The frequency of CNLS at the diagnosis of B-cell ALL was 3.6%. Patients with CNSL at diagnosis had a significantly higher mean presenting leukocyte count ( P = 0.002) and poorer treatment response ( P < 0.05) compared with non-CNSL patients. Moreover, CNSL status was associated with worse 3-year event-free survival ( P = 0.030) and a higher risk of 3-year cumulative incidence of relapse   ( P = 0.008), while no impact was observed on 3-year overall survival ( P = 0.837). Multivariate analysis revealed that CNSL status at diagnosis was an independent predictor with a higher cumulative incidence of relapse (hazard ratio = 2.809, P = 0.016).
Conclusion: CNSL status remains an adverse prognostic factor in childhood B-cell ALL, indicating that additional augmentation of CNS-directed therapy is warranted for patients with CNSL at diagnosis.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Xu, Geng, Liao, Yang, Mai, Wan, Huang, Zheng, Tian, Chen, Chen, Long, Zhen, Liu, Li, Wu, Wang, Kong, Chen, Fang and Li.)
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فهرسة مساهمة: Keywords: acute lymphoblastic leukemia; central nervous system leukemia; childhood; prognosis; relapse
تواريخ الأحداث: Date Created: 20220829 Latest Revision: 20220830
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9399517
DOI: 10.3389/fonc.2022.943761
PMID: 36033509
قاعدة البيانات: MEDLINE
الوصف
تدمد:2234-943X
DOI:10.3389/fonc.2022.943761