دورية أكاديمية
Systemic lipolysis promotes physiological fitness in Drosophila melanogaster .
العنوان: | Systemic lipolysis promotes physiological fitness in Drosophila melanogaster . |
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المؤلفون: | Shang L; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Aughey E; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA., Kim H; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Heden TD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Wang L; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA., Najt CP; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Esch N; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Brunko S; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Abrahante JE; University of Minnesota Informatics Institute, Minneapolis, MN 55455, USA., Macchietto M; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA., Mashek MT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Fairbanks T; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA., Promislow DEL; Department of Biology, University of Washington, Seattle, WA 98195, USA.; Department of Lab Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA., Neufeld TP; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA., Mashek DG; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA. |
المصدر: | Aging [Aging (Albany NY)] 2022 Aug 30; Vol. 14 (16), pp. 6481-6506. Date of Electronic Publication: 2022 Aug 30. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
مواضيع طبية MeSH: | Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Drosophila melanogaster*/metabolism, Animals ; Drosophila/metabolism ; Female ; Lipolysis ; Longevity ; Triglycerides/metabolism |
مستخلص: | Since interventions such as caloric restriction or fasting robustly promote lipid catabolism and improve aging-related phenotypical markers, we investigated the direct effect of increased lipid catabolism via overexpression of bmm ( brummer , FBgn0036449), the major triglyceride hydrolase in Drosophila, on lifespan and physiological fitness. Comprehensive characterization was carried out using RNA-seq, lipidomics and metabolomics analysis. Global overexpression of bmm strongly promoted numerous markers of physiological fitness, including increased female fecundity, fertility maintenance, preserved locomotion activity, increased mitochondrial biogenesis and oxidative metabolism. Increased bmm robustly upregulated the heat shock protein 70 (Hsp70) family of proteins, which equipped the flies with higher resistance to heat, cold, and ER stress via improved proteostasis. Despite improved physiological fitness, bmm overexpression did not extend lifespan. Taken together, these data show that bmm overexpression has broad beneficial effects on physiological fitness, but these effects did not impact lifespan. |
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معلومات مُعتمدة: | K99 AG070104 United States AG NIA NIH HHS; R01 GM136835 United States GM NIGMS NIH HHS; R56 AG051599 United States AG NIA NIH HHS; S10 OD021562 United States OD NIH HHS; K01 DK125258 United States DK NIDDK NIH HHS; R01 AG069768 United States AG NIA NIH HHS; R01 AG055452 United States AG NIA NIH HHS; P30 AG013280 United States AG NIA NIH HHS; R01 AG049494 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: brummer; lipolysis; physiological fitness; proteostasis; stress resistance |
المشرفين على المادة: | 0 (Drosophila Proteins) 0 (Triglycerides) |
تواريخ الأحداث: | Date Created: 20220831 Date Completed: 20220913 Latest Revision: 20230720 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9467406 |
DOI: | 10.18632/aging.204251 |
PMID: | 36044277 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1945-4589 |
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DOI: | 10.18632/aging.204251 |