دورية أكاديمية
The gut microbiome molecular mimicry piece in the multiple sclerosis puzzle.
| العنوان: | The gut microbiome molecular mimicry piece in the multiple sclerosis puzzle. |
|---|---|
| المؤلفون: | Elsayed NS; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States., Aston P; Department of Neurology, Marshfield Clinic Health System, Marshfield, WI, United States., Bayanagari VR; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States., Shukla SK; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2022 Aug 15; Vol. 13, pp. 972160. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*/physiology , Multiple Sclerosis*/microbiology , Neurodegenerative Diseases*, Autoantigens ; Dysbiosis/complications ; Humans ; Molecular Mimicry |
| مستخلص: | The etiological complexity of multiple sclerosis, an immune-mediated, neurodegenerative disease with multifactorial etiology is still elusive because of an incomplete understanding of the complex synergy between contributing factors such as genetic susceptibility and aberrant immune response. Recently, the disease phenotypes have also been shown to be associated with dysbiosis of the gut microbiome, a dynamic reservoir of billions of microbes, their proteins and metabolites capable of mimicring the autoantigens. Microbial factors could potentially trigger the neuroinflammation and symptoms of MS. In this perspective article, we discussed how microbial molecules resulting from a leaky gut might mimic a host's autoantigen, potentially contributing to the disease disequilibrium. It further highlights the importance of targeting the gut microbiome for alternate therapeutic options for the treatment of MS. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Elsayed, Aston, Bayanagari and Shukla.) |
| References: | PLoS One. 2010 Feb 02;5(2):e9009. (PMID: 20126401) Ann Neurol. 2012 Jul;72(1):53-64. (PMID: 22807325) Exp Biol Med (Maywood). 2018 Jan;243(2):159-165. (PMID: 29169241) Sci Rep. 2017 Oct 19;7(1):13537. (PMID: 29051531) Mult Scler. 2018 Dec;24(14):1795-1807. (PMID: 30303445) Neurology. 1998 Sep;51(3):742-7. (PMID: 9748020) Cell Host Microbe. 2008 Oct 16;4(4):337-49. (PMID: 18854238) Anal Biochem. 2017 Jun 1;526:9-21. (PMID: 28300535) Int Immunol. 2009 Aug;21(8):977-90. (PMID: 19561046) Nat Rev Immunol. 2004 Jun;4(6):478-85. (PMID: 15173836) Front Microbiol. 2017 Nov 07;8:2164. (PMID: 29163443) Sci Transl Med. 2014 Nov 19;6(263):263ra158. (PMID: 25411471) Cell Res. 2020 Jun;30(6):492-506. (PMID: 32433595) Proc Natl Acad Sci U S A. 1989 Sep;86(18):7113-7. (PMID: 2571150) Cell. 2020 Mar 19;180(6):1067-1080.e16. (PMID: 32160527) Mult Scler. 2017 Mar;23(3):442-446. (PMID: 27270497) Ann Neurol. 2010 Apr;67(4):452-61. (PMID: 20437580) Sci Adv. 2017 Jul 12;3(7):e1700492. (PMID: 28706993) Neurol Sci. 2017 Mar;38(3):389-398. (PMID: 28078565) J Immunol. 2007 Nov 15;179(10):6604-12. (PMID: 17982050) J Immunol. 2009 Dec 1;183(11):7169-77. (PMID: 19890056) N Engl J Med. 2017 Jun 1;376(22):2122-2133. (PMID: 28564557) Mol Med Rep. 2009 Nov-Dec;2(6):993-8. (PMID: 21475933) Neurology. 2016 Mar 15;86(11):1014-21. (PMID: 26888980) Hum Mol Genet. 1997;6(10):1693-8. (PMID: 9300661) Mucosal Immunol. 2010 Sep;3(5):487-95. (PMID: 20531465) Nat Commun. 2016 Jun 28;7:12015. (PMID: 27352007) Nat Genet. 2013 Nov;45(11):1353-60. (PMID: 24076602) Mult Scler Relat Disord. 2020 Jan;37:101427. (PMID: 32172998) Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22. (PMID: 20660719) J Neurovirol. 2004 Oct;10(5):278-83. (PMID: 15385250) Science. 2022 Jan 21;375(6578):296-301. (PMID: 35025605) Am J Pathol. 2008 Dec;173(6):1714-23. (PMID: 18974295) PLoS One. 2022 Apr 26;17(4):e0264556. (PMID: 35472144) Neurochem Int. 2019 Oct;129:104468. (PMID: 31108132) Front Immunol. 2017 Sep 14;8:1096. (PMID: 28959254) Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. (PMID: 25830558) J Neurol Neurosurg Psychiatry. 2002 Feb;72(2):184-7. (PMID: 11796767) Science. 2013 Aug 2;341(6145):569-73. (PMID: 23828891) Cold Spring Harb Perspect Med. 2018 Jun 1;8(6):. (PMID: 29311123) Mult Scler. 2018 Jul;24(8):1029-1038. (PMID: 28569645) Lancet. 2008 Oct 25;372(9648):1502-17. (PMID: 18970977) Eur J Immunol. 1976 Nov;6(11):805-10. (PMID: 63374) BMC Microbiol. 2019 Dec 30;19(1):309. (PMID: 31888483) Lancet Neurol. 2014 Jul;13(7):700-9. (PMID: 24852507) Genes Immun. 2013 Oct;14(7):434-440. (PMID: 23903824) PLoS One. 2015 Sep 14;10(9):e0137429. (PMID: 26367776) Ann Neurol. 2016 Sep;80(3):443-7. (PMID: 27398819) Eur J Neurol. 2007 Aug;14(8):835-40. (PMID: 17662002) Mult Scler. 2020 Apr;26(5):576-581. (PMID: 31965883) Trends Genet. 2001 Sep;17(9):502-10. (PMID: 11525833) Diseases. 2020 Aug 30;8(3):. (PMID: 32872621) Cell Host Microbe. 2014 Oct 8;16(4):433-7. (PMID: 25299329) J Clin Microbiol. 2006 Jun;44(6):2099-104. (PMID: 16757604) PLoS One. 2014 Jun 10;9(6):e99411. (PMID: 24915454) Nature. 2013 Aug 8;500(7461):232-6. (PMID: 23842501) NPJ Parkinsons Dis. 2021 Mar 10;7(1):27. (PMID: 33692356) Nature. 2011 Aug 10;476(7359):214-9. (PMID: 21833088) Sci Rep. 2016 Jun 27;6:28484. (PMID: 27346372) Sci Transl Med. 2018 Oct 10;10(462):. (PMID: 30305453) Immunology. 2018 Jun;154(2):178-185. (PMID: 29392733) Front Immunol. 2019 Nov 08;10:2608. (PMID: 31781110) Clin Transl Immunology. 2013 Nov 15;2(11):e8. (PMID: 25505950) Brain. 2009 May;132(Pt 5):1175-89. (PMID: 19339255) Nat Med. 2014 Oct;20(10):1147-56. (PMID: 25216636) Science. 2011 Oct 7;334(6052):105-8. (PMID: 21885731) Immunology. 2018 Jun;154(2):230-238. (PMID: 29637999) Nutrients. 2021 Feb 25;13(3):. (PMID: 33669008) PLoS One. 2014 Sep 03;9(9):e106335. (PMID: 25184418) Front Neurosci. 2020 Oct 08;14:578666. (PMID: 33117122) Sci Rep. 2017 Feb 03;7:41473. (PMID: 28155867) Semin Immunol. 2007 Aug;19(4):216-24. (PMID: 17398114) J Immunol. 1994 Apr 15;152(8):3946-57. (PMID: 7511662) EBioMedicine. 2021 Sep;71:103557. (PMID: 34455391) Brain. 2018 Jul 1;141(7):1900-1916. (PMID: 29860380) Brain. 2002 Jan;125(Pt 1):150-8. (PMID: 11834600) Nat Genet. 2007 Sep;39(9):1083-91. (PMID: 17660817) Eur J Neurol. 2016 Aug;23(8):1308-1321. (PMID: 27176462) J Neurosci Res. 2006 Jun;83(8):1432-46. (PMID: 16583400) Nature. 2011 Oct 26;479(7374):538-41. (PMID: 22031325) Med Hypotheses. 2012 Jun;78(6):763-9. (PMID: 22483667) EBioMedicine. 2022 Feb;76:103798. (PMID: 35094961) Annu Rev Neurosci. 2008;31:247-69. (PMID: 18558855) Nat Immunol. 2002 Oct;3(10):940-3. (PMID: 12244309) Brain. 2001 Aug;124(Pt 8):1544-54. (PMID: 11459746) Int J Tryptophan Res. 2010;3:157-67. (PMID: 22084596) Nat Med. 2010 Feb;16(2):228-31. (PMID: 20081863) J Clin Invest. 2005 Jan;115(1):66-75. (PMID: 15630445) Neurotherapeutics. 2018 Jan;15(1):75-91. (PMID: 29067566) Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10713-10718. (PMID: 28893978) Mult Scler. 2020 Dec;26(14):1816-1821. (PMID: 33174475) Microb Pathog. 2018 Apr;117:285-289. (PMID: 29477743) Am J Pathol. 1997 Apr;150(4):1253-66. (PMID: 9094982) Sci Rep. 2019 Jun 20;9(1):8837. (PMID: 31222050) J Clin Invest. 2008 Oct;118(10):3411-9. (PMID: 18769633) Science. 2019 Sep 27;365(6460):. (PMID: 31604244) N Engl J Med. 2007 Aug 30;357(9):851-62. (PMID: 17660530) Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):. (PMID: 29440325) Cold Spring Harb Perspect Med. 2019 Mar 1;9(3):. (PMID: 29500303) JAMA Neurol. 2016 Jul 1;73(7):795-802. (PMID: 27244296) Nat Med. 2016 Jun;22(6):586-97. (PMID: 27158906) Annu Rev Immunol. 1990;8:579-621. (PMID: 2188675) Nat Immunol. 2001 Sep;2(9):797-801. (PMID: 11526389) Cell. 2016 Jun 2;165(6):1332-1345. (PMID: 27259147) Front Immunol. 2017 Oct 25;8:1391. (PMID: 29118761) Brain. 2005 Aug;128(Pt 8):1747-63. (PMID: 15975943) Genes Immun. 2016 Mar;17(2):118-27. (PMID: 26765264) Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. (PMID: 22276073) Ther Adv Neurol Disord. 2019 Sep 25;12:1756286419878323. (PMID: 31598138) Cell Rep. 2017 Aug 8;20(6):1269-1277. (PMID: 28793252) Int Immunopharmacol. 2008 Sep;8(9):1291-7. (PMID: 18602076) Drug Discov Today. 2019 Sep;24(9):1943-1952. (PMID: 30366058) Steroids. 2020 Jun;158:108615. (PMID: 32097613) J Neurol Neuromedicine. 2016;1(7):1-5. (PMID: 27990499) Int Immunopharmacol. 2013 Oct;17(2):483-8. (PMID: 23938252) Cell. 2009 Oct 30;139(3):485-98. (PMID: 19836068) Biochem J. 1994 Jun 1;300 ( Pt 2):281-90. (PMID: 8002928) Front Immunol. 2020 Aug 04;11:1741. (PMID: 32849620) J Clin Neurosci. 2020 Dec;82(Pt B):193-199. (PMID: 33257156) Front Neurosci. 2019 Dec 18;13:1365. (PMID: 31920519) Mult Scler. 2015 Jan;21(1):8-21. (PMID: 25480864) Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):. (PMID: 29358315) |
| فهرسة مساهمة: | Keywords: Epstein-Barr virus; HLA genes; aberrant immune response; gut microbiome; leaky gut; microbial metabolites; molecular mimicry; multiple sclerosis |
| المشرفين على المادة: | 0 (Autoantigens) |
| تواريخ الأحداث: | Date Created: 20220901 Date Completed: 20220908 Latest Revision: 20220920 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9420973 |
| DOI: | 10.3389/fimmu.2022.972160 |
| PMID: | 36045671 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
|---|---|
| DOI: | 10.3389/fimmu.2022.972160 |