دورية أكاديمية
Benefits of combined exercise training on arterial stiffness and blood pressure in spontaneously hypertensive rats treated or not with dexamethasone.
العنوان: | Benefits of combined exercise training on arterial stiffness and blood pressure in spontaneously hypertensive rats treated or not with dexamethasone. |
---|---|
المؤلفون: | Tardelli LP; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Duchatsch F; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Herrera NA; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Ruiz TFR; Joint Graduate Program in Animal Biology, São Paulo State University (UNESP), São José do Rio Preto, SP, Brazil., Pagan LU; Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil., Vicentini CA; Department of Biological Sciences, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Okoshi K; Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil., Amaral SL; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil. |
المصدر: | Frontiers in physiology [Front Physiol] 2022 Aug 15; Vol. 13, pp. 916179. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | Dexamethasone (DEX)-induced arterial stiffness is an important side-effect, associated with hypertension and future cardiovascular events, which can be counteracted by exercise training. The aim of this study was to evaluate the mechanisms induced by combined training to attenuate arterial stiffness and hypertension in spontaneously hypertensive rats treated or not with dexamethasone. Spontaneously hypertensive rats (SHR) underwent combined training for 74 days and were treated with dexamethasone (50 µg/kg s. c .) or saline solution during the last 14 days. Wistar rats were used as controls. Echocardiographic parameters, blood pressure (BP) and pulse wave velocity (PWV), as well as histological analyses of the heart and aorta, carotid and femoral arteries were performed. At the beginning, SHR had higher BP and PWV compared with Wistar rats. After 60 days, while BP increased in sedentary SHR, combined exercise training decreased BP and PWV. After 74d, the higher BP and PWV of sedentary SHR was accompanied by autonomic imbalance to the heart, cardiac remodeling, and higher arterial collagen deposition. DEX treatment did not change these parameters. On the other hand, trained SHR had reduced BP and PWV, which was associated with better autonomic balance to the heart, reduced myocardial collagen deposition, as well as lower arterial collagen deposition. The results of this study suggest that combined training, through the reduction of aortic collagen deposition, is an important strategy to reduce arterial stiffness in spontaneously hypertensive rats, and these lower responses were maintained regardless of dexamethasone treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Tardelli, Duchatsch, Herrera, Ruiz, Pagan, Vicentini, Okoshi and Amaral.) |
References: | Free Radic Biol Med. 2020 May 20;152:1-7. (PMID: 32147395) Clin Sci (Lond). 1999 Jul;97(1):103-9. (PMID: 10369801) J Appl Toxicol. 2021 Oct;41(10):1673-1686. (PMID: 33629383) J Hypertens. 2016 Oct;34(10):1967-76. (PMID: 27434101) Braz J Med Biol Res. 2011 Sep;44(9):814-26. (PMID: 21537612) Hypertension. 2018 Jun;71(6):e13-e115. (PMID: 29133356) PLoS One. 2020 Mar 18;15(3):e0230514. (PMID: 32187237) Med Sci Sports Exerc. 2018 Jun;50(6):1177-1185. (PMID: 29381650) J Vasc Res. 2018;55(3):144-158. (PMID: 29886482) Mol Cell Biochem. 2004 Nov;266(1-2):31-6. (PMID: 15646025) Geroscience. 2021 Feb;43(1):423-432. (PMID: 32529594) Int J Cardiol. 2015 Jan 15;178:69-76. (PMID: 25464222) Menopause. 2017 Mar;24(3):262-268. (PMID: 27779565) Eur J Sport Sci. 2015;15(5):443-57. (PMID: 25251989) Arch Cardiovasc Dis. 2021 Aug-Sep;114(8-9):550-560. (PMID: 33903034) J Hum Hypertens. 2019 Dec;33(12):837-843. (PMID: 31582784) J Hypertens. 2021 Feb 1;39(2):214-222. (PMID: 32833924) Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1532-9. (PMID: 26423710) J Hypertens. 2011 Dec;29(12):2349-58. (PMID: 22045123) J Hypertens. 2020 Jun;38(6):982-1004. (PMID: 32371787) Clin Exp Hypertens. 2017;39(6):546-552. (PMID: 28590143) J Cardiovasc Pharmacol Ther. 2021 Mar;26(2):189-199. (PMID: 32856477) Menopause. 2011 Sep;18(9):980-4. (PMID: 21540753) Front Physiol. 2018 Oct 29;9:1471. (PMID: 30420811) J Hypertens. 2020 Jan;38(1):73-81. (PMID: 31335510) Int J Environ Res Public Health. 2020 May 30;17(11):. (PMID: 32486335) Am J Hypertens. 2019 Nov 15;32(12):1162-1169. (PMID: 31401651) J Vasc Res. 2011;48(6):513-24. (PMID: 21829037) Exp Mol Pathol. 2010 Dec;89(3):351-7. (PMID: 20800592) Arq Bras Cardiol. 2021 Mar;116(3):516-658. (PMID: 33909761) Steroids. 2017 Dec;128:147-154. (PMID: 29054562) Auton Neurosci. 2016 May;197:9-13. (PMID: 26987408) Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R481-8. (PMID: 16914435) Pol Merkur Lekarski. 2019 Jun 28;46(276):257-262. (PMID: 31260435) Mol Cell Biochem. 2017 Jan;424(1-2):87-98. (PMID: 27761848) Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1115-22. (PMID: 26254332) Clin Exp Pharmacol Physiol. 2008 Apr;35(4):477-82. (PMID: 18307745) Muscle Nerve. 2016 May;53(5):779-88. (PMID: 26355638) Physiol Rep. 2019 Aug;7(13):e14107. (PMID: 31264387) J Clin Biochem Nutr. 2020 Jan;66(1):62-66. (PMID: 32001958) J Cardiovasc Pharmacol. 2017 Sep;70(3):194-201. (PMID: 28678054) J Am Soc Hypertens. 2018 Aug;12(8):605-613. (PMID: 29945776) MethodsX. 2020 Apr 27;7:100901. (PMID: 32426246) PLoS One. 2017 Dec 12;12(12):e0189535. (PMID: 29232407) Steroids. 2020 Apr;156:108573. (PMID: 31904375) Cell Physiol Biochem. 2015;36(1):61-74. (PMID: 25924734) Hypertension. 2003 Oct;42(4):851-7. (PMID: 12913057) Curr Hypertens Rep. 2015 Nov;17(11):87. (PMID: 26423529) PLoS One. 2020 Jun 10;15(6):e0233785. (PMID: 32521542) PLoS One. 2020 Jul 6;15(7):e0235983. (PMID: 32628712) Expert Rev Endocrinol Metab. 2012 May;7(3):273-280. (PMID: 30780842) Gynecol Endocrinol. 2018 Jan;34(1):78-82. (PMID: 28675704) PLoS One. 2019 Jan 7;14(1):e0210292. (PMID: 30615666) Cardiovasc Toxicol. 2021 May;21(5):365-374. (PMID: 33387253) Circ Res. 2001 Sep 28;89(7):623-9. (PMID: 11577028) Eur Heart J. 2018 Sep 1;39(33):3021-3104. (PMID: 30165516) ESC Heart Fail. 2018 Apr;5(2):222-232. (PMID: 29235244) Medicine (Baltimore). 2019 May;98(20):e15484. (PMID: 31096447) J Steroid Biochem Mol Biol. 2014 Sep;143:357-64. (PMID: 24861267) J Hypertens. 2006 Dec;24(12):2437-43. (PMID: 17082727) Aging Clin Exp Res. 2020 May;32(5):781-788. (PMID: 31302897) Front Physiol. 2021 Feb 10;12:624515. (PMID: 33679438) Am J Phys Med Rehabil. 2015 Sep;94(9):687-95. (PMID: 25357149) Int J Rheum Dis. 2017 May;20(5):628-638. (PMID: 26176346) J Cardiovasc Pharmacol. 2021 Apr 1;77(4):519-528. (PMID: 33394824) Diabetologia. 2018 Sep;61(9):1935-1945. (PMID: 29797021) PLoS One. 2018 Sep 7;13(9):e0202731. (PMID: 30192778) J Hum Hypertens. 2020 Jul;34(7):505-511. (PMID: 31548619) BMC Public Health. 2012 Aug 28;12:704. (PMID: 23006411) Physiol Rev. 2017 Oct 1;97(4):1555-1617. (PMID: 28954852) PLoS One. 2020 Aug 13;15(8):e0237237. (PMID: 32790701) Clin Exp Pharmacol Physiol. 2006 Nov;33(11):1029-34. (PMID: 17042910) Front Physiol. 2021 Nov 23;12:742338. (PMID: 34887771) J Biomech Eng. 2018 Jul 1;140(7):. (PMID: 29560498) Am J Hypertens. 2019 Oct 16;32(11):1091-1100. (PMID: 31342054) J Pediatr Endocrinol Metab. 2018 Dec 19;31(12):1315-1323. (PMID: 30433871) Eur J Pharmacol. 2011 Oct 1;668(1-2):194-200. (PMID: 21723861) |
فهرسة مساهمة: | Keywords: aerobic training; arteries; collagen deposition; hypertension; pulse wave velocity; resistance training |
تواريخ الأحداث: | Date Created: 20220901 Latest Revision: 20220907 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC9420846 |
DOI: | 10.3389/fphys.2022.916179 |
PMID: | 36045742 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-042X |
---|---|
DOI: | 10.3389/fphys.2022.916179 |