دورية أكاديمية
Benefits of combined exercise training on arterial stiffness and blood pressure in spontaneously hypertensive rats treated or not with dexamethasone.
| العنوان: | Benefits of combined exercise training on arterial stiffness and blood pressure in spontaneously hypertensive rats treated or not with dexamethasone. |
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| المؤلفون: | Tardelli LP; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Duchatsch F; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Herrera NA; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Ruiz TFR; Joint Graduate Program in Animal Biology, São Paulo State University (UNESP), São José do Rio Preto, SP, Brazil., Pagan LU; Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil., Vicentini CA; Department of Biological Sciences, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil., Okoshi K; Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil., Amaral SL; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil.; Department of Physical Education, São Paulo State University (UNESP), School of Sciences, Bauru, SP, Brazil. |
| المصدر: | Frontiers in physiology [Front Physiol] 2022 Aug 15; Vol. 13, pp. 916179. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | Dexamethasone (DEX)-induced arterial stiffness is an important side-effect, associated with hypertension and future cardiovascular events, which can be counteracted by exercise training. The aim of this study was to evaluate the mechanisms induced by combined training to attenuate arterial stiffness and hypertension in spontaneously hypertensive rats treated or not with dexamethasone. Spontaneously hypertensive rats (SHR) underwent combined training for 74 days and were treated with dexamethasone (50 µg/kg s. c .) or saline solution during the last 14 days. Wistar rats were used as controls. Echocardiographic parameters, blood pressure (BP) and pulse wave velocity (PWV), as well as histological analyses of the heart and aorta, carotid and femoral arteries were performed. At the beginning, SHR had higher BP and PWV compared with Wistar rats. After 60 days, while BP increased in sedentary SHR, combined exercise training decreased BP and PWV. After 74d, the higher BP and PWV of sedentary SHR was accompanied by autonomic imbalance to the heart, cardiac remodeling, and higher arterial collagen deposition. DEX treatment did not change these parameters. On the other hand, trained SHR had reduced BP and PWV, which was associated with better autonomic balance to the heart, reduced myocardial collagen deposition, as well as lower arterial collagen deposition. The results of this study suggest that combined training, through the reduction of aortic collagen deposition, is an important strategy to reduce arterial stiffness in spontaneously hypertensive rats, and these lower responses were maintained regardless of dexamethasone treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Tardelli, Duchatsch, Herrera, Ruiz, Pagan, Vicentini, Okoshi and Amaral.) |
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| فهرسة مساهمة: | Keywords: aerobic training; arteries; collagen deposition; hypertension; pulse wave velocity; resistance training |
| تواريخ الأحداث: | Date Created: 20220901 Latest Revision: 20220907 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9420846 |
| DOI: | 10.3389/fphys.2022.916179 |
| PMID: | 36045742 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-042X |
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| DOI: | 10.3389/fphys.2022.916179 |