دورية أكاديمية
The Molecular Pathogenesis and Targeted Therapies for Cholangiocarcinoma.
| العنوان: | The Molecular Pathogenesis and Targeted Therapies for Cholangiocarcinoma. |
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| المؤلفون: | Param NJ; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 11th Floor Room 70-E, New York, NY 10029, USA., Bramel ER; Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 11th Floor Room 70-E, New York, NY 10029, USA., Sia D; Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 11th Floor Room 70-E, New York, NY 10029, USA. Electronic address: daniela.sia@mssm.edu. |
| المصدر: | Surgical pathology clinics [Surg Pathol Clin] 2022 Sep; Vol. 15 (3), pp. 529-539. Date of Electronic Publication: 2022 Aug 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101491209 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9157 (Electronic) Linking ISSN: 18759157 NLM ISO Abbreviation: Surg Pathol Clin Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/genetics , Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/genetics, Bile Ducts, Intrahepatic/metabolism ; Bile Ducts, Intrahepatic/pathology ; Humans ; Molecular Targeted Therapy ; Tumor Microenvironment |
| مستخلص: | Cholangiocarcinoma (CCA) is a group of malignancies of the bile ducts with high mortality rates and limited treatment options. In the past decades, remarkable efforts have been dedicated toward elucidating the specific molecular signaling pathways and oncogenic loops driving cholangiocarcinogenesis to ultimately develop more effective therapies. Despite some recent advances, an extensive intra- and inter-tumor heterogeneity together with a poorly understood immunosuppressive microenvironment significantly compromises the efficacy of available treatments. Here, we provide a concise review of the latest advances and current knowledge of the molecular pathogenesis of CCA focusing on clinically relevant aberrations as well as future research avenues. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cholangiocarcinoma; Microenvironment; Molecular aberrations; Precision medicine; Targeted therapies |
| تواريخ الأحداث: | Date Created: 20220901 Date Completed: 20220907 Latest Revision: 20220907 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.path.2022.05.006 |
| PMID: | 36049834 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1875-9157 |
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| DOI: | 10.1016/j.path.2022.05.006 |