دورية أكاديمية
أعرض في EDS

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm.

التفاصيل البيبلوغرافية
العنوان: Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm.
المؤلفون: Mastella MH; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., Roggia I; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil., Turra BO; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., Teixeira CF; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., Assmann CE; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Brazil., Morais-Pinto L; Anatomical Design Laboratory, Morphology Department, Federal University of Santa Maria, Santa Maria, Brazil., Vidal T; Graduate Program of Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Brazil., Melazzo C; Graduate Program of Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Brazil., Jung IEDC; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., Barbisan F; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil., da Cruz IBM; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: ibmcruz@hotmail.com.
المصدر: Neuroscience [Neuroscience] 2022 Oct 15; Vol. 502, pp. 25-40. Date of Electronic Publication: 2022 Sep 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Oligochaeta*/metabolism , Soil Pollutants*/analysis , Soil Pollutants*/metabolism , Soil Pollutants*/pharmacology , Receptors, Nicotinic*/metabolism, Animals ; Superoxides/metabolism ; Superoxides/pharmacology ; Rotenone/toxicity ; Soil/chemistry ; Plastics/metabolism ; Plastics/pharmacology ; Inflammation/chemically induced
مستخلص: Background: Some studies have suggested that mitochondrial dysfunction and a superoxide imbalance could increase susceptibility to chronic stressful events, contributing to the establishment of chronic inflammation and the development of mood disorders. The mitochondrial superoxide imbalance induced by some molecules, such as rotenone, could be evolutionarily conserved, causing behavioral, immune, and neurological alterations in animals with a primitive central nervous system.
Objective: Behavioral, immune, and histological markers were analyzed in Eisenia fetida earthworms chronically exposed to rotenone for 14 days.
Methods: Earthworms were placed in artificial soil containing 30 nM of rotenone distributed into a plastic cup that allowed the earthworms to leave and return freely into the ground. Since these organisms prefer to be buried, the model predicted that the earthworms would necessarily have to return to the rotenone-contaminated medium, creating a stressful condition. The effect on survival behavior in the immune and histological body wall and ventral nervous ganglia (VNG) structures, as well as gene expression related to inflammation and mitochondrial and neuromuscular changes.
Results: Rotenone-induced loss of earthworm escape behavior and immune alterations indicated a chronic inflammatory state. Some histological changes in the body wall and VNG indicated a possible earthworm reaction aimed at protecting against rotenone. Overexpression of the nicotinic acetylcholine receptor gene (nAChR α5) in neural tissues could also help earthworms reduce the degenerative effects of rotenone on dopaminergic neurons.
Conclusion: These data suggest that mitochondrial dysfunction could be an evolutionarily conserved element that induces inflammatory and behavioral changes related to chronic stress.
Competing Interests: Conflicts of interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
(Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: earthworm; inflammation; neurodegeneration; psychiatric disorders; superoxide
المشرفين على المادة: 11062-77-4 (Superoxides)
03L9OT429T (Rotenone)
0 (Soil Pollutants)
0 (Soil)
0 (Plastics)
0 (Receptors, Nicotinic)
تواريخ الأحداث: Date Created: 20220904 Date Completed: 20221025 Latest Revision: 20221110
رمز التحديث: 20231215
DOI: 10.1016/j.neuroscience.2022.07.035
PMID: 36058342
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2022.07.035