دورية أكاديمية
أعرض في EDS

Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use.

التفاصيل البيبلوغرافية
العنوان: Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use.
المؤلفون: Dickerman RD; Department of Neurosurgery, University of North Texas Health Science Center (UNTHSC), Frisco, Texas, USA., Williamson J; Department of Neurosurgery, University of North Texas Health Science Center (UNTHSC), Frisco, Texas, USA., Mathew E; Department of Neurosurgery, University of North Texas Health Science Center (UNTHSC), Frisco, Texas, USA., Butt CM; Department of Neuroscience, Inotiv-Boulder, Inc., Boulder, Colorado, USA., Bird CW; Department of Neuroscience, Inotiv-Boulder, Inc., Boulder, Colorado, USA., Hood LE; Department of Neuroscience, Inotiv-Boulder, Inc., Boulder, Colorado, USA., Grimshaw V; Department of Neuroscience, Inotiv-Boulder, Inc., Boulder, Colorado, USA.
المصدر: Neurotrauma reports [Neurotrauma Rep] 2022 Aug 16; Vol. 3 (1), pp. 321-332. Date of Electronic Publication: 2022 Aug 16 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101773091 Publication Model: eCollection Cited Medium: Internet ISSN: 2689-288X (Electronic) Linking ISSN: 2689288X NLM ISO Abbreviation: Neurotrauma Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc., [2020]-
مستخلص: Branched-chain amino acids (BCAAs) are known to be neurorestorative after traumatic brain injury (TBI). Despite clinically significant improvements in severe TBI patients given BCAAs after TBI, the approach is largely an unrecognized option. Further, TBI continues to be the most common cause of morbidity and mortality in adolescents and adults. To date, no study has evaluated whether BCAAs can be preventive or neuroprotective if taken before a TBI. We hypothesized that if BCAAs were elevated in the circulation before TBI, the brain would readily access the BCAAs and the severity of injury would be reduced. Before TBI induction with a standard weight-drop method, 50 adult mice were randomized into groups that were shams, untreated, and pre-treated, post-treated, or pre- + post-treated with BCAAs. Pre-treated mice received BCAAs through supplemented water and were dosed by oral gavage 45 min before TBI induction. All mice underwent beam walking to assess motor recovery, and the Morris water maze assessed cognitive function post-injury. On post-injury day 14, brains were harvested to assess levels of astrocytes and microglia with glial fibrillary acidic protein (GFAP) and ionized calcium-binding adapter molecule 1 (IBA-1) immunohistochemistry, respectively. Pre-treated and pre- +post-treated mice exhibited significantly better motor recovery and cognitive function than the other groups. The pre- + post-treated group had the best overall memory performance, whereas the pre-treated and post-treated groups only had limited improvements in memory compared to untreated animals. Pre- + post-treated brains had levels of GFAP that were similar to the sham group, whereas the pre-only and post-only groups showed increases. Although trends existed, no meaningful changes in IBA-1 were detected. This is the first study, animal or human, to demonstrate that BCAA are neuroprotective and substantiates their neurorestorative benefits after TBI, most likely through the important roles of BCAAs to glutamate homeostasis.
Competing Interests: No authors have a personal or institutional financial interest in the drugs, materials, or devices mentioned in the article. C.M.B., V.G., C.W.B., and L.E.H. are employees of Inotiv-Boulder, Inc., a contract research organization.
(© Rob D. Dickerman et al., 2022; Published by Mary Ann Liebert, Inc.)
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فهرسة مساهمة: Keywords: branched-chain amino acids (BCAAs); concussion; glutamate; neuroprotective; traumatic brain injury
تواريخ الأحداث: Date Created: 20220905 Latest Revision: 20220907
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9438436
DOI: 10.1089/neur.2022.0031
PMID: 36060454
قاعدة البيانات: MEDLINE
الوصف
تدمد:2689-288X
DOI:10.1089/neur.2022.0031