دورية أكاديمية
أعرض في EDS

Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models.

التفاصيل البيبلوغرافية
العنوان: Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models.
المؤلفون: van Ham WB; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands., Kessler EL; Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University of Utrecht, Utrecht, the Netherlands., Oerlemans MIFJ; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Handoko ML; Department of Cardiology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Sluijter JPG; Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University of Utrecht, Utrecht, the Netherlands., van Veen TAB; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands., den Ruijter HM; Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., de Jager SCA; Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2022 May 25; Vol. 7 (8), pp. 844-857. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: At least one-half of the growing heart failure population consists of heart failure with preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the syndrome, and many related comorbidities emphasize the need for adequate experimental animal models to study the etiology of HFpEF, as well as its comorbidities and pathophysiological changes. The strengths and weaknesses of available animal models have been reviewed extensively with the general consensus that a "1-size-fits-all" model does not exist, because no uniform HFpEF patient exists. In fact, HFpEF patients have been categorized into HFpEF phenogroups based on comorbidities and symptoms. In this review, we therefore study which animal model is best suited to study the different phenogroups-to improve model selection and refinement of animal research. Based on the published data, we extrapolated human HFpEF phenogroups into 3 animal phenogroups (containing small and large animals) based on reports and definitions of the authors: animal models with high (cardiac) age (phenogroup aging); animal models focusing on hypertension and kidney dysfunction (phenogroup hypertension/kidney failure); and models with hypertension, obesity, and type 2 diabetes mellitus (phenogroup cardiometabolic syndrome). We subsequently evaluated characteristics of HFpEF, such as left ventricular diastolic dysfunction parameters, systemic inflammation, cardiac fibrosis, and sex-specificity in the different models. Finally, we scored these parameters concluded how to best apply these models. Based on our findings, we propose an easy-to-use classification for future animal research based on clinical phenogroups of interest.
Competing Interests: This work was supported by Netherlands Cardiovascular Research Initiative, with the support of the Dutch Heart Foundation, the Netherlands (CVON2018-30 PREDICT2 to Drs van Ham and van Veen, Senior Clinical Scientist grant 2020T058 to Dr Handoko; EARLY-HFpEF Young Talent Grant 2015-10 to Dr Kessler, RECONNEXT 2020B008 and IMPRESS 2020B004 to Drs Kessler, Handoko, den Ruijter, and de Jager). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: ANGII, angiotensin II; BNP, brain natriuretic peptide; DOCA, deoxycorticosterone acetate; DahlSS, Dahl salt sensitive; HF, heart failure; HFD, high-fat diet; HFHS, high fat, high sugar; HFpEF; HFpEF, heart failure with preserved ejection fraction; HHR, hypertrophic heart rat; IVRT, isovolumetric relaxation time; L-NAME, Nω-nitrol-arginine methyl ester; LV, left ventricle/ventricular; LVDD; LVDD, left ventricular diastolic dysfunction; LVEDP, left ventricular end-diastolic pressure; LVEF, left ventricular ejection fraction; PO, pressure overload; T2DM, type 2 diabetes mellitus; ZSF1, Zucker fatty and spontaneously hypertensive; animal models; heart failure with preserved ejection fraction; left ventricular diastolic dysfunction; phenogroups
تواريخ الأحداث: Date Created: 20220905 Latest Revision: 20220907
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9436760
DOI: 10.1016/j.jacbts.2021.12.009
PMID: 36061340
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2021.12.009