دورية أكاديمية
Copper regulation disturbance linked to oxidative stress and cell death during Zika virus infection in human astrocytes.
| العنوان: | Copper regulation disturbance linked to oxidative stress and cell death during Zika virus infection in human astrocytes. |
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| المؤلفون: | Puig-Pijuan T; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.; Laboratory of Biomembranes, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Souza LRQ; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil., Pedrosa CDSG; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil., Higa LM; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Monteiro FL; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Tanuri A; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Valverde RHF; Laboratory of Biomembranes, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Einicker-Lamas M; Laboratory of Biomembranes, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Rehen SK; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.; Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. |
| المصدر: | Journal of cellular biochemistry [J Cell Biochem] 2022 Dec; Vol. 123 (12), pp. 1997-2008. Date of Electronic Publication: 2022 Sep 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004>- : Hoboken, NJ : Wiley-Liss Original Publication: New York : Liss, c1982- |
| مواضيع طبية MeSH: | Zika Virus Infection*/metabolism , Zika Virus* , Induced Pluripotent Stem Cells*/metabolism, Humans ; Infant, Newborn ; Female ; Pregnancy ; Astrocytes/metabolism ; Copper/pharmacology ; Copper/metabolism ; Oxidative Stress ; Cell Death ; Chelating Agents/metabolism ; Chelating Agents/pharmacology |
| مستخلص: | The Zika virus (ZIKV) caused neurological abnormalities in more than 3500 Brazilian newborns between 2015 and 2020. Data have pointed to oxidative stress in astrocytes as well as to dysregulations in neural cell proliferation and cell cycle as important events accounting for the cell death and neurological complications observed in Congenital Zika Syndrome. Copper imbalance has been shown to induce similar alterations in other pathologies, and disturbances in copper homeostasis have already been described in viral infections. Here, we investigated copper homeostasis imbalance as a factor that could contribute to the cytotoxic effects of ZIKV infection in astrocytes. Human induced pluripotent stem cell-derived astrocytes were infected with ZIKV; changes in the gene expression of copper homeostasis proteins were analyzed. The effect of the administration of CuCl (© 2022 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: Zika Virus; copper; human astrocytes; oxidative stress |
| المشرفين على المادة: | 789U1901C5 (Copper) 0 (Chelating Agents) |
| تواريخ الأحداث: | Date Created: 20220905 Date Completed: 20221223 Latest Revision: 20221223 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jcb.30323 |
| PMID: | 36063501 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4644 |
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| DOI: | 10.1002/jcb.30323 |