دورية أكاديمية
أعرض في EDS

Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1α/IGFBP3 pathway.

التفاصيل البيبلوغرافية
العنوان: Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1α/IGFBP3 pathway.
المؤلفون: Arabzadeh E; Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran., Norouzi Kamareh M; PHD of Exercise Physiology, Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran., Ramirez-Campillo R; Department of Physical Activity Sciences, Universidad de Los Lagos, Santiago, Chile.; Exercise and Rehabilitation Sciences Laboratory, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile., Mirnejad R; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran., Masti Y; MSc of Cellular Molecular, Department of Biological Sciences, Faculty of Basic Sciences, Imam Hossein University, Tehran, Iran., Shirvani H; Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
المصدر: Journal of food biochemistry [J Food Biochem] 2022 Dec; Vol. 46 (12), pp. e14397. Date of Electronic Publication: 2022 Sep 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 7706045 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-4514 (Electronic) Linking ISSN: 01458884 NLM ISO Abbreviation: J Food Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: 2008- : Hoboken, NJ : Wiley
Original Publication: Westport, Conn. : Food & Nutrition Press
مواضيع طبية MeSH: Apoptosis* , Myocytes, Cardiac*, Animals ; Male ; Rats ; Aging ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Caspase 3/metabolism ; Eosine Yellowish-(YS)/metabolism ; Eosine Yellowish-(YS)/pharmacology ; Hematoxylin/metabolism ; Hematoxylin/pharmacology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Membrane Proteins/pharmacology ; Mitochondrial Proteins/metabolism ; Mitochondrial Proteins/pharmacology ; Oxidative Stress ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats, Wistar
مستخلص: In this study, we consider the effect of treadmill exercise training, green tea extract, and combination of exercise training with green tea extract, in aging rat cardiac myocytes apoptosis markers (i.e., HIF-1α, BNIP3, Bax, IGFBP3, Bcl-2, caspase-3, MDA, GPx, Bax/Bcl-2 ratio, and hematoxylin and eosin). Twenty-four rats (male, Wistar) were divided into four groups: (I) control (n = 6), (II) green tea extract (n = 6), (III) exercise (n = 6), and (IV) exercise + green tea extract (n = 6). Exercise groups performed 12 weeks of running on a rodent treadmill at 17-27 m.min -1 (60-75% vo2peak) for 5 days per week. Green tea extract involved 300 mg.kg -1 , 5 days per week for 12 weeks. After being euthanized, the blood and heart were collected for glutathione peroxidase (GPx) activity, malondialdehyde (MDA), HIF-1α, BNIP3, insulin-like growth factor-binding protein-3 (IGFBP3), Bax, Bcl-2, caspase-3, Bax/Bcl-2 ratio, and hematoxylin and eosin level measurements. Compared to control, the ANOVA demonstrated significant effects of green tea extract (F = 14.646 to 32.453, p = .009 to .001, η = 0.295 to 0.715) and exercise training (F = 9.213 to 133.828, p = .007 to .001, η = 0.315 to η = 0.870) on HIF-1a, BNIP3, Bax, IGFBP3, Bcl-2, caspase-3, MDA, GPx, and Bax/Bcl-2 ratio. However, the combination of green tea extract and exercise had no effect on the aforementioned apoptosis markers when compared to isolated green tea extract or isolated exercise (F = 0.002 to 4.068, p = .057 to .968, and η = 0.001 to 0.169). PRACTICAL APPLICATIONS: Isolated exercise training and green tea extract may provide a cardioprotective effect on aging-induced apoptosis through the downregulation of HIF-1α, BNIP3, and IGFBP3 in the heart muscle. However, further research is needed to clarify the effects of combining exercise and green tea.
(© 2022 Wiley Periodicals LLC.)
References: Agnetti, G., Bordoni, A., Angeloni, C., Leoncini, E., Guarnieri, C., Caldarera, C., Biagi, P. L., & Hrelia, S. (2005). Green tea modulation of inducible nitric oxide synthase in hypoxic/reoxygenated cardiomyocytes. Biochimie, 87(5), 457-460.
Al-Awaida, W., Akash, M., Aburubaiha, Z., Talib, W. H., & Shehadeh, H. (2014). Chinese green tea consumption reduces oxidative stress, inflammation and tissues damage in smoke exposed rats. Iranian Journal of Basic Medical Sciences, 17(10), 740-746.
Alique, M., Sánchez-López, E., Bodega, G., Giannarelli, C., Carracedo, J., & Ramírez, R. (2020). Hypoxia-inducible factor-1α: The master regulator of endothelial cell senescence in vascular aging. Cell, 9(1), 1-21.
Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., Wu, M., Aston, C. E., & Lyons, T. J. (2011). Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition, 27(2), 206-213.
Boeno, F. P., Ramis, T. R., Munhoz, S. V., Farinha, J. B., Moritz, C. E., Leal-Menezes, R., Ribeiro, J. L., Christou, D. D., & Reischak-Oliveira, A. (2020). Effect of aerobic and resistance exercise training on inflammation, endothelial function and ambulatory blood pressure in middle-aged hypertensive patients. Journal of Hypertension, 38(12), 2501-2509.
Bordoni, A., Hrelia, S., Angeloni, C., Giordano, E., Guarnieri, C., Caldarera, C. M., & Biagi, P. L. (2002). Green tea protection of hypoxia/reoxygenation injury in cultured cardiac cells. The Journal of Nutritional Biochemistry, 13(2), 103-111.
Burton, T. R., & Gibson, S. B. (2009). The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death & Differentiation, 16(4), 515-523.
Carbonell, T., & Rama, R. (2009). Respiratory hypoxia and oxidative stress in the brain. Is the endogenous erythropoietin an antioxidant? Current Chemical Biology, 3(3), 238-252.
Chang, R.-L., Lin, J.-W., Hsieh, D. J.-Y., Yeh, Y.-L., Shen, C.-Y., Day, C.-H., Ho, T. J., Viswanadha, V. P., Kuo, W. W., & Huang, C.-Y. (2015). Long-term hypoxia exposure enhanced IGFBP-3 protein synthesis and secretion resulting in cell apoptosis in H9c2 myocardial cells. Growth Factors, 33(4), 275-281.
Chen, Y. F., Pandey, S., Day, C. H., Chen, Y. F., Jiang, A. Z., Ho, T. J., Chen, R. J., Padma, V. V., Kuo, W. W., & Huang, C. Y. (2018). Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. Journal of Cellular Physiology, 233(4), 3660-3671.
Chilton, W., O'Brien, B., & Charchar, F. (2017). Telomeres, aging and exercise: Guilty by association? International Journal of Molecular Sciences, 18(12), 1-32.
Chinnadurai, G., Vijayalingam, S., & Gibson, S. B. (2008). BNIP3 subfamily BH3-only proteins: Mitochondrial stress sensors in normal and pathological functions. Oncogene, 27(1), S114-S127.
Corrado, C., & Fontana, S. (2020). Hypoxia and HIF signaling: One axis with divergent effects. International Journal of Molecular Sciences, 21(16), 1-17.
Curtis, A. B., Karki, R., Hattoum, A., & Sharma, U. C. (2018). Arrhythmias in patients≥ 80 years of age: Pathophysiology, management, and outcomes. Journal of the American College of Cardiology, 71(18), 2041-2057.
Darband, S. G., Sadighparvar, S., Yousefi, B., Kaviani, M., Mobaraki, K., & Majidinia, M. (2020). Combination of exercise training and L-arginine reverses aging process through suppression of oxidative stress, inflammation, and apoptosis in the rat heart. Pflügers Archiv-European Journal of Physiology, 472(2), 169-178.
Dehne, N., & Brüne, B. (2014). Sensors, transmitters, and targets in mitochondrial oxygen shortage-A hypoxia-inducible factor relay story. Antioxidants & Redox Signaling, 20(2), 339-352.
Diao, J.-X., Ou, J.-Y., Dai, H., Li, H.-Y., Huang, W., Hua, H.-Y., Xie, T., Wang, M., & Yang, Y.-G. (2020). Antioxidant and antiapoptotic polyphenols from green tea extract ameliorate CCl 4-induced acute liver injury in mice. Chinese Journal of Integrative Medicine, 26(10), 736-744.
Distler, J. H., Jüngel, A., Pileckyte, M., Zwerina, J., Michel, B. A., Gay, R. E., Kowal-Bielecka, O., Matucci-Cerinic, M., Schett, G., Marti, H. H., Gay, S., & Distler, O. (2007). Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 56(12), 4203-4215.
Dorn, G., & Kirshenbaum, L. (2008). Cardiac reanimation: Targeting cardiomyocyte death by BNIP3 and NIX/BNIP3L. Oncogene, 27(1), S158-S167.
Edlich, F. (2018). BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochemical and Biophysical Research Communications, 500(1), 26-34.
Feng, C.-C., Lin, C.-C., Lai, Y.-P., Chen, T.-S., Marthandam Asokan, S., Lin, J.-Y., Lin, K. H., Viswanadha, V. P., Kuo, W. W., & Huang, C.-Y. (2016). Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression. Growth Factors, 34(3-4), 73-86.
Gad, S. B., & Zaghloul, D. M. (2013). Beneficial effects of green tea extract on liver and kidney functions, ultrastructure, lipid profile and hematological parameters in aged male rats. Global Veterinaria, 11(2), 191-205.
Habibi, P., Alihemmati, A., Ahmadiasl, N., Fateh, A., & Anvari, E. (2020). Exercise training attenuates diabetes-induced cardiac injury through increasing miR-133a and improving pro-apoptosis/anti-apoptosis balance in ovariectomized rats. Iranian Journal of Basic Medical Sciences, 23(1), 79-85.
Hadi, A., Pourmasoumi, M., Kafeshani, M., Karimian, J., Maracy, M. R., & Entezari, M. H. (2017). The effect of green tea and sour tea (Hibiscus sabdariffa L.) supplementation on oxidative stress and muscle damage in athletes. Journal of dietary supplements, 14(3), 346-357.
Høydal, M. A., Wisløff, U., Kemi, O. J., & Ellingsen, Ø. (2007). Running speed and maximal oxygen uptake in rats and mice: Practical implications for exercise training. European Journal of Preventive Cardiology, 14(6), 753-760.
Huang, Y. T., Liu, C. H., Yang, Y. C., Aneja, R., Wen, S. Y., Huang, C. Y., & Kuo, W. W. (2019). ROS-and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis. Journal of Cellular Physiology, 234(8), 13557-13570.
Iyer, S., Anwari, K., Alsop, A. E., Yuen, W. S., Huang, D. C., Carroll, J., Smith, N. A., Smith, B. J., Dewson, G., & Kluck, R. M. (2016). Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies. Nature Communications, 7(1), 1-10.
Jówko, E., Długołęcka, B., Makaruk, B., & Cieśliński, I. (2015). The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. European Journal of Nutrition, 54(5), 783-791.
Ko, I.-G., Kim, S.-E., Kim, C.-J., & Jee, Y.-S. (2013). Treadmill exercise alleviates aging-induced apoptosis in rat cardiac myocytes. International Journal of Gerontology, 7(3), 152-157.
Kwak, H.-B. (2013). Effects of aging and exercise training on apoptosis in the heart. Journal of Exercise Rehabilitation, 9(2), 212-219.
Kwak, H. B., Song, W., & Lawler, J. M. (2006). Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. The FASEB Journal, 20(6), 791-793.
Kwong, L. K., & Sohal, R. S. (2000). Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Archives of Biochemistry and Biophysics, 373(1), 16-22.
Lay, S., Kuo, W.-W., Shibu, M. A., Ho, T.-J., Cheng, S.-M., Day, C. H., Ban, B., Wang, S., Li, Q., & Huang, C.-Y. (2021). Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis. Journal of Advanced Research, 28(1), 35-41.
Li, G., Zhang, Y., Thabane, L., Mbuagbaw, L., Liu, A., Levine, M. A., & Holbrook, A. (2015). Effect of green tea supplementation on blood pressure among overweight and obese adults: A systematic review and meta-analysis. Journal of Hypertension, 33(2), 243-254.
Lindholm, M., & Rundqvist, H. (2015). Skeletal muscle HIF-1 and exercise. Experimental Physiology, 10(1), 1-4.
Lindholm, M. E., Fischer, H., Poellinger, L., Johnson, R. S., Gustafsson, T., Sundberg, C. J., & Rundqvist, H. (2014). Negative regulation of HIF in skeletal muscle of elite endurance athletes: A tentative mechanism promoting oxidative metabolism. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 307(3), R248-R255.
Lindholm, M. E., & Rundqvist, H. (2016). Skeletal muscle hypoxia-inducible factor-1 and exercise. Experimental Physiology, 101(1), 28-32.
Narasimhan, M., & Rajasekaran, N. S. (2016). Exercise, Nrf2 and antioxidant signaling in cardiac aging. Frontiers in Physiology, 7(1), 1-8.
Qin, B., Polansky, M. M., Harry, D., & Anderson, R. A. (2010). Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. Molecular Nutrition & Food Research, 54(S1), S14-S23.
Rodgers, J. L., Jones, J., Bolleddu, S. I., Vanthenapalli, S., Rodgers, L. E., Shah, K., Karia, K., & Panguluri, S. K. (2019). Cardiovascular risks associated with gender and aging. Journal of Cardiovascular Development and Disease, 6(2), 1-18.
Roh, J. D., Houstis, N., Yu, A., Chang, B., Yeri, A., Li, H., Hobson, R., Lerchenmüller, C., Vujic, A., Chaudhari, V., Damilano, F., & Rosenzweig, A. (2020). Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell, 19(6), 1-12.
Serban, C., Sahebkar, A., Antal, D., Ursoniu, S., & Banach, M. (2015). Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. Nutrition, 31(9), 1061-1071.
Shih, H., Lee, B., Lee, R. J., & Boyle, A. J. (2011). The aging heart and post-infarction left ventricular remodeling. Journal of the American College of Cardiology, 57(1), 9-17.
Singh, B. N., Shankar, S., & Srivastava, R. K. (2011). Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochemical Pharmacology, 82(12), 1807-1821.
Soori, R., Ghram, A., Shahneh, M. Z., Choobineh, S., Costa, P. B., & Voltarelli, F. A. (2021). Effects of high intensity interval training and aging on cardiac muscle apoptosis markers in C57BL/6 mice. Sport Sciences for Health, 17(1), 173-179.
Sylviana, N., Helja, N., Qolbi, H. H., Goenawan, H., Lesmana, R., Syamsunarno, M. R. A., Agustina, H., Tiksnadi, B. B., Megantara, I., Tarawan, V. M., Setiawan, S., Hernowo, B., Supratman, U., & Purba, A. (2018). Effect of swimming exercise to cardiac PGC-1 α and HIF-1 α gene expression in mice. Asian Journal of Sports Medicine, 9(4), 1-7.
Tiwari, V., & Wilson, D. M., III. (2019). DNA damage and associated DNA repair defects in disease and premature aging. The American Journal of Human Genetics, 105(2), 237-257.
Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., Israels, S., Hakem, R., & Greenberg, A. (2000). BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Molecular and Cellular Biology, 20(15), 5454-5468.
Wang, H., Bei, Y., Lu, Y., Sun, W., Liu, Q., Wang, Y., Cao, Y., Chen, P., Xiao, J., & Kong, X. (2015). Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1α and Akt activation. Cellular Physiology and Biochemistry, 35(6), 2159-2168.
Xu, X., & Chen, L. (2019). Projection of long-term care costs in China, 2020-2050: Based on the Bayesian quantile regression method. Sustainability, 11(13), 1-13.
Yang, L., Fu, S., Zhu, X., Zhang, L.-M., Yang, Y., Yang, X., & Liu, H. (2010). Hyperbranched acidic polysaccharide from green tea. Biomacromolecules, 11(12), 3395-3405.
Yeo, E.-J. (2019). Hypoxia and aging. Experimental & Molecular Medicine, 51(6), 1-15.
Zhang, Y., Liu, D., Hu, H., Zhang, P., Xie, R., & Cui, W. (2019). HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury. Biomedicine & Pharmacotherapy, 120(1), 1-8.
فهرسة مساهمة: Keywords: Sports Nutritional Sciences; aging; apoptosis; exercise; heart; hypoxia-inducible factor-proline dioxygenases
المشرفين على المادة: 0 (bcl-2-Associated X Protein)
0 (BNIP3 protein, rat)
EC 3.4.22.- (Caspase 3)
TDQ283MPCW (Eosine Yellowish-(YS))
YKM8PY2Z55 (Hematoxylin)
0 (Membrane Proteins)
0 (Mitochondrial Proteins)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (Hif1a protein, rat)
تواريخ الأحداث: Date Created: 20220907 Date Completed: 20230110 Latest Revision: 20230112
رمز التحديث: 20240829
DOI: 10.1111/jfbc.14397
PMID: 36069470
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-4514
DOI:10.1111/jfbc.14397