دورية أكاديمية
أعرض في EDS

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation.

التفاصيل البيبلوغرافية
العنوان: Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation.
المؤلفون: Stakenborg M; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Abdurahiman S; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., De Simone V; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Goverse G; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Stakenborg N; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., van Baarle L; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Wu Q; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Pirottin D; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liege University, Liege, Belgium., Kim JS; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Chappell-Maor L; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Pintelon I; Laboratory of Cell Biology & Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium., Thys S; Laboratory of Cell Biology & Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium., Pollenus E; Laboratory of Immunoparasitology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical research, KU Leuven, Leuven, Belgium., Boon L; Polpharma Biologics, Utrecht, the Netherlands., Van den Steen P; Laboratory of Immunoparasitology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical research, KU Leuven, Leuven, Belgium., Hao M; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Van Ginderachter JA; Cellular and Molecular Immunology Lab, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium., Boeckxstaens GE; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium., Timmermans JP; Laboratory of Cell Biology & Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium., Jung S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Marichal T; Laboratory of Immunophysiology, GIGA Institute, Liege University, Liege, Belgium.; Department of Functional Sciences, Faculty of Veterinary Medicine, Liege University, Liege, Belgium., Ibiza S; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium. sales.IbizaMartinez@uantwerpen.be.; Laboratory of Cell Biology & Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium. sales.IbizaMartinez@uantwerpen.be., Matteoli G; Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium. gianluca.matteoli@kuleuven.be.
المصدر: Mucosal immunology [Mucosal Immunol] 2022 Jun; Vol. 15 (6), pp. 1296-1308. Date of Electronic Publication: 2022 Sep 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: New York, NY : Nature Pub. Group, c2008-
مواضيع طبية MeSH: Macrophages* , Monocytes*, Humans ; Inflammation ; Neuroglia ; Anti-Inflammatory Agents
مستخلص: Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte recruitment and anti-inflammatory Mφ differentiation in this paradigm. Here, we investigate Mφ heterogeneity at different stages of muscularis inflammation and determine how environmental cues can attract and activate tissue-protective Mφs. Results showed that muscularis inflammation induced marked alterations in mononuclear phagocyte populations associated with a rapid infiltration of Ly6c + monocytes that locally acquired unique transcriptional states. Trajectory inference analysis revealed two main pro-resolving Mφ subpopulations during the resolution of muscularis inflammation, i.e. Cd206 + MhcII hi and Timp2 + MhcII lo Mφs. Interestingly, we found that damage to the micro-environment upon muscularis inflammation resulted in EGC activation, which in turn stimulated monocyte infiltration and the consequent differentiation in anti-inflammatory CD206 + Mφs via CCL2 and CSF1, respectively. In addition, CSF1-CSF1R signaling was shown to be essential for the differentiation of monocytes into CD206 + Mφs and EGC proliferation during muscularis inflammation. Our study provides a comprehensive insight into pro-resolving Mφ differentiation and their regulators during muscularis inflammation. We deepened our understanding in the interaction between EGCs and Mφs, thereby highlighting pro-resolving Mφ differentiation as a potential novel therapeutic strategy for the treatment of intestinal inflammation.
(© 2022. The Author(s).)
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المشرفين على المادة: 0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20220907 Date Completed: 20221130 Latest Revision: 20230203
رمز التحديث: 20230203
مُعرف محوري في PubMed: PMC9705256
DOI: 10.1038/s41385-022-00563-2
PMID: 36071145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-3456
DOI:10.1038/s41385-022-00563-2