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First case report of monkeypox in Brazil: clinical manifestations and differential diagnosis with sexually transmitted infections.

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العنوان: First case report of monkeypox in Brazil: clinical manifestations and differential diagnosis with sexually transmitted infections.
المؤلفون: Lima EL; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Barra LAC; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Borges LMS; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Medeiros LA; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Tomishige MYS; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Santos LSLA; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Silva AJDD; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Rodrigues CCM; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Azevedo LCF; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil., Villas-Boas LS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Silva CAMD; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Coletti TM; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Manuli ER; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Claro IM; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.; Imperial College London, MRC Centre for Global Infectious Disease Analysis, London, United Kingdom., Romano CM; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Ramundo MS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Moutinho T; Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil., Sabino EC; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Lindoso JAL; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Protozoologia, São Paulo, São Paulo, Brazil., Figueiredo-Mello C; Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo, Brazil.
المصدر: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2022 Sep 05; Vol. 64, pp. e54. Date of Electronic Publication: 2022 Sep 05 (Print Publication: 2022).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9946 (Electronic) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo
مواضيع طبية MeSH: Mpox (monkeypox)*/diagnosis , Mpox (monkeypox)*/epidemiology , Mpox (monkeypox)*/pathology , Sexually Transmitted Diseases*/diagnosis , Sexually Transmitted Diseases*/epidemiology, Adult ; Animals ; Brazil ; Diagnosis, Differential ; Disease Outbreaks ; Humans ; Male
مستخلص: In 2022, an outbreak of monkeypox is being reported in non-endemic areas, with unusual clinical manifestations. The detailed clinical description of the first patient that received the diagnosis of monkeypox in Brazil is reported here, whose clinical manifestations can easily lead to misdiagnosis of sexually transmitted infections. A 41 years old male presented to an emergency room with a vesicular rash with eight days of evolution. He had traveled to Portugal and Spain and reported non-penetrative sexual involvement with three different male individuals. On the third day of symptoms, he sought medical care and received empirical treatment directed to sexually transmitted infections. As the symptoms did not improve, he sought medical attention at an infectious disease referral center presenting, on admission, an ulcerated penile lesion with central necrotic crusts, a disseminated pleomorphic skin rash and an oropharyngeal ulcer. The monkeypox diagnosis was suspected due to the characteristics of the lesions and the history of intimate contact with casual partners, and it was later confirmed by sequencing the almost complete monkeypox genome. The patient was hospitalized for pain control, which required opiate administration. He developed a secondary bacterial infection on the penile lesions, which were treated with oral antibiotics. He was discharged after 14 days, with lesions in process of re-epithelialization. Given the current outbreak, we must consider the possibility of monkeypox in patients with suggestive lesions, anywhere on the body (including the genitals), added to an epidemiological link or history of intimate contact with strangers or casual partners.
References: Glob Adv Health Med. 2013 Sep;2(5):38-43. (PMID: 24416692)
J Infect. 2022 Sep;85(3):334-363. (PMID: 35659548)
Rev Inst Med Trop Sao Paulo. 2022 Jun 24;64:e48. (PMID: 35749419)
Infect Dis Clin North Am. 2019 Dec;33(4):1027-1043. (PMID: 30981594)
J Med Virol. 2022 Jun 12;:. (PMID: 35692117)
MMWR Morb Mortal Wkly Rep. 2022 Aug 12;71(32):1018-1022. (PMID: 35951487)
MMWR Morb Mortal Wkly Rep. 2022 Aug 12;71(32):1023-1028. (PMID: 35951495)
Lancet Infect Dis. 2022 Aug;22(8):1153-1162. (PMID: 35623380)
Euro Surveill. 2022 Jun;27(22):. (PMID: 35656836)
Clin Infect Dis. 2020 Nov 5;71(8):e210-e214. (PMID: 32052029)
Clin Infect Dis. 2014 Jan;58(2):260-7. (PMID: 24158414)
تواريخ الأحداث: Date Created: 20220908 Date Completed: 20220912 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9448252
DOI: 10.1590/S1678-9946202264054
PMID: 36074449
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-9946
DOI:10.1590/S1678-9946202264054