دورية أكاديمية
أعرض في EDS

Evaluation of Oxidative Stress Parameters and Genotoxic Effects in Patients With Work-Related Asthma and Silicosis.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Oxidative Stress Parameters and Genotoxic Effects in Patients With Work-Related Asthma and Silicosis.
المؤلفون: Kurt OK; From the Department of Pulmonary Medicine and Occupational Medicine, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey (Dr Ozlem Kar); Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey (Drs Ozlem Kar, Dilsiz, and Basaran); Department of Pulmonary Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey (Dr Ergun); Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bulent Ecevit University, Zonguldak, Turkey (Anlar); Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ibrahim Cecen University, Agri, Turkey (Ms Hazar); Department of Pulmonary Medicine, Occupational and Environmental Diseases Hospital, Ankara, Turkey (Dr Karatas); and Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Baskent University, Ankara, Turkey (Dr Basaran)., Ergun D, Anlar HG, Hazar M, Aydin Dilsiz S, Karatas M, Basaran N
المصدر: Journal of occupational and environmental medicine [J Occup Environ Med] 2023 Feb 01; Vol. 65 (2), pp. 146-151. Date of Electronic Publication: 2022 Sep 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9504688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-5948 (Electronic) Linking ISSN: 10762752 NLM ISO Abbreviation: J Occup Environ Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, MD : Williams & Wilkins, c1995-
مواضيع طبية MeSH: Silicosis* , Asthma*, Humans ; Catalase ; 8-Hydroxy-2'-Deoxyguanosine ; Oxidative Stress ; Malondialdehyde ; DNA Damage ; Superoxide Dismutase ; Glutathione Peroxidase/metabolism
مستخلص: Objective: To determine the mechanistic roles of oxidative stress, inflammation, and genotoxicity parameters in patients with work-related asthma (WRA) and silicosis.
Methods: Thirty-eight healthy office workers, 27 employees with a history of exposure and no disease, 24 employees with WRA, and 23 employees with silicosis were included in this study. Superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and interleukins (IL) 17, 23, and 27 levels were measured in the serum. Genotoxic damage was evaluated by calculating the frequency of micronuclei in swab samples and 8-hydroxy-2'-deoxyguanosine in serum.
Results: Serum superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, 8-hydroxy-2'-deoxyguanosine, and IL-17, IL-23, and IL-27 levels were found to be statistically significantly higher in the exposure, WRA, and silicosis groups compared with the control group. The frequency of micronuclei in buccal epithelial cells of the patient group was found to be significantly higher than that of the control group.
Conclusion: These results may provide information for molecular mechanisms and early diagnosis of WRA and silicosis and will be a guide for taking precautions in the early period.
Competing Interests: Conflict of interest: None declared.
(Copyright © 2022 American College of Occupational and Environmental Medicine.)
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المشرفين على المادة: EC 1.11.1.6 (Catalase)
88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
4Y8F71G49Q (Malondialdehyde)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.11.1.9 (Glutathione Peroxidase)
تواريخ الأحداث: Date Created: 20220908 Date Completed: 20230207 Latest Revision: 20230818
رمز التحديث: 20230819
DOI: 10.1097/JOM.0000000000002701
PMID: 36075368
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5948
DOI:10.1097/JOM.0000000000002701