دورية أكاديمية
Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory.
العنوان: | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory. |
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المؤلفون: | Maity S; Department of Physiology, Neuroscience, and Behavioral Sciences, St. George's University School of Medicine, True Blue FZ818, Grenada., Abbaspour R; Department of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada., Nahabedian D; The Center for Biomedical Visualization, Department of Anatomical Sciences, St. George's University School of Medicine, True Blue FZ818, Grenada., Connor SA; Department of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 Aug 31; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 31. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Long-Term Potentiation*/physiology , Norepinephrine*/physiology, Animals ; Epigenesis, Genetic ; Mammals/metabolism ; Neuronal Plasticity/genetics ; Receptors, Adrenergic, beta/metabolism ; Synapses/metabolism |
مستخلص: | The noradrenergic system is implicated in neuropathologies contributing to major disorders of the memory, including post-traumatic stress disorder and Alzheimer's disease. Determining the impact of norepinephrine on cellular function and plasticity is thus essential for making inroads into our understanding of these brain conditions, while expanding our capacity for treating them. Norepinephrine is a neuromodulator within the mammalian central nervous system which plays important roles in cognition and associated synaptic plasticity. Specifically, norepinephrine regulates the formation of memory through the stimulation of β-ARs, increasing the dynamic range of synaptic modifiability. The mechanisms through which NE influences neural circuit function have been extended to the level of the epigenome. This review focuses on recent insights into how the noradrenergic recruitment of epigenetic modifications, including DNA methylation and post-translational modification of histones, contribute to homo- and heterosynaptic plasticity. These advances will be placed in the context of synaptic changes associated with memory formation and linked to brain disorders and neurotherapeutic applications. Competing Interests: The authors declare no conflict of interest. |
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فهرسة مساهمة: | Keywords: beta-adrenergic receptors; epigenome; hippocampus; memory; norepinephrine; synaptic plasticity; transcription |
المشرفين على المادة: | 0 (Receptors, Adrenergic, beta) X4W3ENH1CV (Norepinephrine) |
تواريخ الأحداث: | Date Created: 20220909 Date Completed: 20220912 Latest Revision: 20220913 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9456295 |
DOI: | 10.3390/ijms23179916 |
PMID: | 36077313 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms23179916 |