دورية أكاديمية
أعرض في EDS

Insights into Early Onset Colorectal Cancer through Analysis of Normal Colon Organoids of Familial Adenomatous Polyposis Patients.

التفاصيل البيبلوغرافية
العنوان: Insights into Early Onset Colorectal Cancer through Analysis of Normal Colon Organoids of Familial Adenomatous Polyposis Patients.
المؤلفون: Devall MA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.; Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA., Eaton S; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.; Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA., Ali MW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA., Powell SM; Digestive Health Center, University of Virginia, Charlottesville, VA 22903, USA., Li L; Department of Family Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22911, USA., Casey G; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.; Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22911, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.
المصدر: Cancers [Cancers (Basel)] 2022 Aug 26; Vol. 14 (17). Date of Electronic Publication: 2022 Aug 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Early onset colorectal cancer (EOCRC) rates have increased in recent decades. While lowering the recommended age for routine colonoscopies to 45 may reduce this burden, such measures do not address those who develop CRC before that age. Additional measures are needed to identify individuals at-risk for CRC. To better define transcriptomic events that precede the development of CRC, we performed RNA-sequencing analysis in colon organoids derived from seven healthy and six familial adenomatous polyposis (FAP) patients. This led to the identification of 2635 significant differentially expressed genes (FDR < 0.05). Through secondary analysis of publicly available datasets, we found that these genes were enriched for significant genes also present in FAP CRC and non-hereditary CRC datasets, including a subset that were unique to EOCRC. By exposing FAP colon organoids to a three-day ethanol treatment, we found that two EOCRC-relevant genes were also targets of CRC related lifestyle factors. Our data provides unique insight into the potential, early mechanisms of CRC development in colon epithelial cells, which may provide biomarkers for patient monitoring. We also show how modifiable lifestyle factors may further alter genes relevant to EOCRC, adding weight to the hypothesis that such factors represent an important contributor to increased EOCRC incidence.
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معلومات مُعتمدة: R01 CA204279 United States CA NCI NIH HHS; R01 CA143237 United States NH NIH HHS; R01 CA143237 United States CA NCI NIH HHS; P20 CA233216 United States CA NCI NIH HHS; R01 CA204279 United States NH NIH HHS
فهرسة مساهمة: Keywords: RNA-seq; colon organoid; early onset colorectal cancer; familial adenomatous polyposis
تواريخ الأحداث: Date Created: 20220909 Latest Revision: 20240517
رمز التحديث: 20240517
مُعرف محوري في PubMed: PMC9454756
DOI: 10.3390/cancers14174138
PMID: 36077675
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers14174138