دورية أكاديمية
Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase.
| العنوان: | Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase. |
|---|---|
| المؤلفون: | van de Munckhof A; Department of Neurology (A.v.d.M., K.K., M.S.v.K., J.M.C.), Amsterdam University Medical Centers, University of Amsterdam, the Netherlands., Lindgren E; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (E.L., K.J., T.T.).; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (E.L., K.J., T.T.)., Kleinig TJ; Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia (T.J.K.)., Field TS; Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada (T.S.F., V.D.)., Cordonnier C; University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, France (C.C., F.C.)., Krzywicka K; Department of Neurology (A.v.d.M., K.K., M.S.v.K., J.M.C.), Amsterdam University Medical Centers, University of Amsterdam, the Netherlands., Poli S; Department of Neurology and Stroke, University Hospital Tuebingen (S.P., A.M., J.M.), Eberhard-Karls University, Germany.; Hertie Institute for Clinical Brain Research (S.P., J.M.), Eberhard-Karls University, Germany., Sánchez van Kammen M; Department of Neurology (A.v.d.M., K.K., M.S.v.K., J.M.C.), Amsterdam University Medical Centers, University of Amsterdam, the Netherlands., Borhani-Haghighi A; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Iran (A.B.-H.)., Lemmens R; Department of Neurology, University Hospitals Leuven, Belgium (R.L., A.D.)., Scutelnic A; Department of Neurology (A.S., M.R.H., M.A.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Ciccone A; Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy (A. Ciccone)., Gattringer T; Department of Neurology, Medical University of Graz, Austria (T.G.)., Wittstock M; Department of Neurology, University Hospital Rostock, Germany (M. Wittstock)., Dizonno V; Division of Neurology, Vancouver Stroke Program, University of British Columbia, Vancouver, Canada (T.S.F., V.D.)., Devroye A; Department of Neurology, University Hospitals Leuven, Belgium (R.L., A.D.)., Elkady A; Department of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia (A.E.)., Günther A; Department of Neurology, Jena University Hospital, Germany (A.G.)., Cervera A; Royal Darwin Hospital, Darwin, Northern Territory, Australia (A. Cervera)., Mengel A; Department of Neurology and Stroke, University Hospital Tuebingen (S.P., A.M., J.M.), Eberhard-Karls University, Germany., Chew BLA; Department of Neurology, John Hunter Hospital, Newcastle, Australia (B.L.A.C., C.G.-E.)., Buck B; Division of Neurology, University of Alberta Hospital, Edmonton, Canada (B.B.)., Zanferrari C; Department of Neurology, Azienda Ospedaliera di Melegnano e della Martesana, Italy (C.Z.)., Garcia-Esperon C; Department of Neurology, John Hunter Hospital, Newcastle, Australia (B.L.A.C., C.G.-E.)., Jacobi C; Department of Neurology, Krankenhaus Nordwest, Frankfurt am Main, Germany (C.J.)., Soriano C; Department of Neurology, Hospital General de Castellón, Castelló, Spain (C.S.)., Michalski D; Department of Neurology, Leipzig University Hospital, Germany (D.M., J. Pelz)., Zamani Z; Department of Neurology, Firoozabadi Hospital (Z.Z.), Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran., Blacquiere D; Division of Neurology, The Ottawa Hospital, Canada (D.B.)., Johansson E; Department Clinical Science, Wallenberg Center for Molecular Medicine (WCMM), Umeå University, Sweden (E.J.)., Cuadrado-Godia E; Department of Neurology, University Hospital del Mar, Barcelona, Spain (E.C.-G.)., Vuillier F; Stroke Unit, University Hospital of Besancon, France (F.V.)., Bode FJ; Department of Neurology, Universitätsklinikum Bonn, Germany (F.J.B., J.Z.)., Caparros F; University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, France (C.C., F.C.)., Maier F; Department of Neurology, Caritas Hospital Saarbrücken, Germany (F.M.)., Tsivgoulis G; Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Greece (G.T.)., Katzberg HD; Department of Neuromuscular Medicine, Toronto General Hospital, Canada (H.D.K.)., Duan J; Department of Neurology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China (J.D.)., Burrow J; Department of Neurology, Royal Darwin Hospital, Tiwi, Australia (J.B.)., Pelz J; Department of Neurology, Leipzig University Hospital, Germany (D.M., J. Pelz)., Mbroh J; Department of Neurology and Stroke, University Hospital Tuebingen (S.P., A.M., J.M.), Eberhard-Karls University, Germany.; Hertie Institute for Clinical Brain Research (S.P., J.M.), Eberhard-Karls University, Germany., Oen J; Department of Neurology, Antonius Ziekenhuis, Sneek, the Netherlands (J.O.)., Schouten J; Department of Neurology, Rijnstate Hospital Arnhem, the Netherlands (J.S.)., Zimmermann J; Department of Neurology, Universitätsklinikum Bonn, Germany (F.J.B., J.Z.)., Ng K; Department of Neurology, Royal North Shore Hospital, Sydney, Australia (K.N., M. Wronski, S.C.)., Garambois K; Department of Neurology, CHU Grenoble Alpes, France (K.G., P.C.)., Petruzzellis M; Department of Neurology, AOU Consorziale Policlinico di Bari, Italy (M.P.)., Carvalho Dias M; Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Portugal (M.C.D.)., Ghiasian M; Department of Neurology, Sina Hospital, Hamadan University of Medical Science, Iran (M.G.)., Romoli M; Neurology and Stroke Unit, Department of Neuroscience, Bufalini Hospital, Cesena, Italy (M.R.)., Miranda M; Department of Neurology, Hospital de Cascais Dr. José de Almeida, Cascais, Portugal (M.M.)., Wronski M; Department of Neurology, Royal North Shore Hospital, Sydney, Australia (K.N., M. Wronski, S.C.)., Skjelland M; Department of Neurology, Oslo University Hospital, Norway (M.S.)., Almasi-Dooghaee M; Department of Neurology (M.A.-D., Z.M.), Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran., Cuisenier P; Department of Neurology, CHU Grenoble Alpes, France (K.G., P.C.)., Murphy S; Acute Stroke Service, Mater Misericordiae University Hospital, UCD School of Medicine and RCSI Medical School, Dublin, Ireland (S. Murphy)., Timsit S; Department of Neurology, Stroke Unit, Hôpital de la Cavale Blanche, CHRU de Brest (University Hospital), Université de Bretagne Occidentale, Inserm 1078, Brest, France (S.T.)., Coutts SB; Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, Calgary, Canada (S.B.C.)., Schönenberger S; Department of Neurology, Heidelberg University Hospital, Germany (S.S., S.N.)., Nagel S; Department of Neurology, Heidelberg University Hospital, Germany (S.S., S.N.)., Hiltunen S; Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland (S.H., T.T., J. Putaala)., Chatterton S; Department of Neurology, Royal North Shore Hospital, Sydney, Australia (K.N., M. Wronski, S.C.)., Cox T; Department of Neurology, University Hospital Southampton NHS Foundation Trust, United Kingdom (T.C.)., Bartsch T; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany (T.B.)., Shaygannejad V; Isfahan University of Medical Sciences (IUMS), Isfahan Neurosciences Research Center (INRC), Iran (V.S.).; Department of Internal (INRC), Iran (V.S.)., Mirzaasgari Z; Department of Neurology (M.A.-D., Z.M.), Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran., Middeldorp S; Department of Internal Medicine and Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (S. Middeldorp)., Levi MM; Department of Vascular Medicine (M.M.L.), Amsterdam University Medical Centers, University of Amsterdam, the Netherlands.; National Institute for Health Research, University College London Hospitals (UCLH), Biomedical Research Centre, London, United Kingdom (M.M.L.)., Kremer Hovinga JA; Department of Hematology (J.A.K.H.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Jood K; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (E.L., K.J., T.T.).; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (E.L., K.J., T.T.)., Tatlisumak T; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (E.L., K.J., T.T.).; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (E.L., K.J., T.T.).; Department of Neurology, Helsinki University Hospital, University of Helsinki, Finland (S.H., T.T., J. Putaala)., Putaala J; Department of Neurology, AOU Consorziale Policlinico di Bari, Italy (M.P.)., Heldner MR; Department of Neurology (A.S., M.R.H., M.A.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Arnold M; Department of Neurology (A.S., M.R.H., M.A.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Aguiar de Sousa D; Stroke Centre, Lisbon Central University Hospital Centre, Portugal (D.A.d.S.).; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal (D.A.d.S., J.M.F.)., Ferro JM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal (D.A.d.S., J.M.F.)., Coutinho JM; Department of Neurology (A.v.d.M., K.K., M.S.v.K., J.M.C.), Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. |
| مؤلفون مشاركون: | Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group |
| المصدر: | Stroke [Stroke] 2022 Oct; Vol. 53 (10), pp. 3206-3210. Date of Electronic Publication: 2022 Sep 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Dallas : American Heart Association |
| مواضيع طبية MeSH: | COVID-19*/prevention & control , COVID-19 Vaccines*/adverse effects , Intracranial Thrombosis*/diagnosis , Thrombocytopenia* , Thrombosis* , Vaccines* , Venous Thrombosis*, Adult ; Cerebral Hemorrhage ; Female ; Humans ; Male ; Risk Factors ; SARS-CoV-2 |
| مستخلص: | Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0-2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization). Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94-194). Two patients died during follow-up (3% [95% CI, 1%-11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%-94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed). Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up. |
| References: | Int J Stroke. 2022 Feb;17(2):189-197. (PMID: 33724104) JAMA Neurol. 2021 Nov 1;78(11):1314-1323. (PMID: 34581763) N Engl J Med. 2021 Nov 4;385(19):1815-1816. (PMID: 34496199) Stroke. 2022 Jun;53(6):1892-1903. (PMID: 35240862) N Engl J Med. 2021 Jun 3;384(22):2092-2101. (PMID: 33835769) Neurology. 2022 Feb 15;98(7):e759-e768. (PMID: 34921101) Clin Appl Thromb Hemost. 2002 Oct;8(4):347-52. (PMID: 12516684) N Engl J Med. 2021 Oct 28;385(18):1680-1689. (PMID: 34379914) Stroke. 2004 Mar;35(3):664-70. (PMID: 14976332) Vaccines (Basel). 2021 Nov 17;9(11):. (PMID: 34835275) |
| فهرسة مساهمة: | Keywords: hospitalization; intracranial thrombosis; mortality; thrombocytopenia; vaccination; venous thrombosis |
| المشرفين على المادة: | 0 (COVID-19 Vaccines) 0 (Vaccines) |
| تواريخ الأحداث: | Date Created: 20220909 Date Completed: 20220928 Latest Revision: 20221025 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9508952 |
| DOI: | 10.1161/STROKEAHA.122.039575 |
| PMID: | 36082668 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4628 |
|---|---|
| DOI: | 10.1161/STROKEAHA.122.039575 |