دورية أكاديمية
أعرض في EDS

Allergen recognition by specific effector Th2 cells enables IL-2-dependent activation of regulatory T-cell responses in humans.

التفاصيل البيبلوغرافية
العنوان: Allergen recognition by specific effector Th2 cells enables IL-2-dependent activation of regulatory T-cell responses in humans.
المؤلفون: Lozano-Ojalvo D; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, New York, USA., Tyler SR; Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Aranda CJ; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, New York, USA., Wang J; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA., Sicherer S; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA., Sampson HA; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, New York, USA., Wood RA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Burks AW; Department of Medicine and Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Jones SM; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA., Leung DYM; Department of Pediatrics, National Jewish Health, Denver, Colorado, USA., de Lafaille MC; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, New York, USA., Berin MC; Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, New York, USA.
المصدر: Allergy [Allergy] 2023 Mar; Vol. 78 (3), pp. 697-713. Date of Electronic Publication: 2022 Sep 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Wiley-Blackwell
Original Publication: Copenhagen, Munksgaard.
مواضيع طبية MeSH: T-Lymphocytes, Regulatory* , Food Hypersensitivity*, Humans ; Allergens ; Th2 Cells ; Interleukin-2
مستخلص: Type 2 allergen-specific T cells are essential for the induction and maintenance of allergies to foods, and Tregs specific for these allergens are assumed to be involved in their resolution. However, it has not been convincingly demonstrated whether allergen-specific Treg responses are responsible for the generation of oral tolerance in humans. We observed that sustained food allergen exposure in the form of oral immunotherapy resulted in increased frequency of Tregs only in individuals with lasting clinical tolerance. We sought to identify regulatory components of the CD4 + T-cell response to food allergens by studying their functional activation over time in vitro and in vivo. Two subsets of Tregs expressing CD137 or CD25/OX40 were identified with a delayed kinetics of activation compared with clonally enriched pathogenic effector Th2 cells. Treg activation was dependent on IL-2 derived from effector T cells. In vivo exposure to peanut in the form of an oral food challenge of allergic subjects induced a delayed and persistent activation of Tregs after initiation of the allergen-specific Th2 response. The novel finding of our work is that a sustained wave of Treg activation is induced by the release of IL-2 from Th2 effector cells, with the implication that therapeutic administration of IL-2 could improve current OIT approaches.
(© 2022 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: R01 AI130343 United States AI NIAID NIH HHS; UM1 AI130570 United States AI NIAID NIH HHS; K99 HG011270 United States HG NHGRI NIH HHS; R01 AI151707 United States AI NIAID NIH HHS; U19 AI136053 United States AI NIAID NIH HHS; UM1 AI130781 United States AI NIAID NIH HHS; R01 AI153708 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: IL-2; antigen-specific T cell; food allergy; oral tolerance; peanut; regulatory T cell
المشرفين على المادة: 0 (Allergens)
0 (Interleukin-2)
تواريخ الأحداث: Date Created: 20220912 Date Completed: 20230306 Latest Revision: 20240628
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10111618
DOI: 10.1111/all.15512
PMID: 36089900
قاعدة البيانات: MEDLINE
الوصف
تدمد:1398-9995
DOI:10.1111/all.15512