دورية أكاديمية
أعرض في EDS

The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic Retinopathy.

التفاصيل البيبلوغرافية
العنوان: The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic Retinopathy.
المؤلفون: Pramanik S; Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020 West Bengal, India., Banerjee K; Decision Sciences Area, Indian Institute of Management Lucknow, Uttar Pradesh 226013, India., Mondal LK; Department of Ophthalmology, Regional Institute of Ophthalmology, Medical College Campus, Kolkata, 700073 West Bengal, India.
المصدر: Journal of diabetes research [J Diabetes Res] 2022 Sep 01; Vol. 2022, pp. 3886710. Date of Electronic Publication: 2022 Sep 01 (Print Publication: 2022).
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019>-: London, United Kingdom : Hindawi Limited
Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/drug therapy , Diabetic Retinopathy*/metabolism, Glucose ; Glycation End Products, Advanced ; Humans ; Hypoglycemic Agents/therapeutic use ; Vascular Endothelial Growth Factor A ; Vitamin E/therapeutic use ; Vitamins/therapeutic use
مستخلص: Excessive intracellular glucose in insulin-independent tissues including nerve, nephron, lens, and retina invites mishandling of metabolism of glucose resulting in a background of increased oxidative stress, advanced glycation end products (AGE) formation, lipid peroxidation, and failure of antioxidant defense systems in type 2 diabetes mellitus (T2DM). All these detrimental biochemical anomalies ultimately attack biological membranes and especially capillary beds of the retina, resulting in the breakdown of the inner blood-retinal barrier and the initiation of diabetic retinopathy (DR). If these disarrays are corrected to a large extent, the development of DR can be avoided or delayed. In this prospective clinical trial, 185 patients with T2DM who received B vitamins, vitamin C, and vitamin E along with antidiabetic medication for five years demonstrated a slower rate of the development of DR and reduced abnormal biochemical mediators like reactive oxygen species (ROS), malondialdehyde (MDA), AGE, and vascular endothelial growth factor (VEGF) compared to 175 T2DM individuals who were treated with only antihyperglycemic drugs.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2022 Subhasish Pramanik et al.)
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المشرفين على المادة: 0 (Glycation End Products, Advanced)
0 (Hypoglycemic Agents)
0 (Vascular Endothelial Growth Factor A)
0 (Vitamins)
1406-18-4 (Vitamin E)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20220912 Date Completed: 20220913 Latest Revision: 20220913
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9458381
DOI: 10.1155/2022/3886710
PMID: 36090588
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6753
DOI:10.1155/2022/3886710