دورية أكاديمية
Description of Hospitalizations due to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Based on Vaccination Status.
| العنوان: | Description of Hospitalizations due to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Based on Vaccination Status. |
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| المؤلفون: | Moffa MA; Medicine Institute and Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Shively NR; Medicine Institute and Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Carr DR; Department of Pharmacy, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Bremmer DN; Department of Pharmacy, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Buchanan C; Department of Pharmacy, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Trienski TL; Department of Pharmacy, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Jacobs MW; Medicine Institute, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Saini V; Medicine Institute and Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Walsh TL; Medicine Institute and Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, Pennsylvania, USA. |
| المصدر: | Open forum infectious diseases [Open Forum Infect Dis] 2022 Aug 25; Vol. 9 (9), pp. ofac438. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| مستخلص: | Background: Limited descriptive data exist regarding the clinical characteristics of hospitalizations due to the severe acute respiratory syndrome coronavirus 2 Omicron variant based on vaccination status. Methods: This was a retrospective cohort study of all patients hospitalized with a diagnosis of coronavirus disease 2019 (COVID-19) between 15 January 2022 and 15 February 2022 across 9 hospitals in a large health network. Data were extracted by manual records review. Results: A total of 351 of 452 (77.7%) unvaccinated, 209 of 331 (63.1%) fully vaccinated, and 107 of 163 (65.6%) boosted patients hospitalized with a COVID-19 diagnosis were determined to be admitted specifically due to COVID-19 ( P < .001). Most (85%) boosted patients admitted due to COVID-19 were at least 65 years old and/or had severe immunosuppression, compared to 72.2% of fully vaccinated and 60.7% of unvaccinated patients ( P < .001). Significantly more unvaccinated patients (34.2%) required >6 L/minute of supplemental oxygen compared to fully vaccinated (24.4%) and boosted (25.2%) patients ( P = .027). The age-adjusted vaccine effectiveness (VE) against hospitalization due to COVID-19 was estimated to be 81.1% and 94.1% for full vaccination and boosted status, respectively, whereas VE against mortality related to COVID-19 was estimated to be 84.7% and 94.8%, respectively. Conclusions: During the Omicron BA.1 sublineage wave, unvaccinated patients hospitalized with a COVID-19 diagnosis were more likely than vaccinated patients to be admitted specifically due to COVID-19. Despite being younger with fewer comorbidities, unvaccinated patients required higher levels of care. Vaccination with a booster provides the greatest protection against hospitalization and death from COVID-19. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
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| فهرسة مساهمة: | Keywords: COVID-19; Omicron; SARS-CoV-2; hospitalization; vaccination |
| تواريخ الأحداث: | Date Created: 20220912 Latest Revision: 20220913 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9452155 |
| DOI: | 10.1093/ofid/ofac438 |
| PMID: | 36092825 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2328-8957 |
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| DOI: | 10.1093/ofid/ofac438 |