دورية أكاديمية
Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells.
| العنوان: | Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells. |
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| المؤلفون: | Lima APB; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Laboratório de Pesquisas Clínicas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Melo AS; Laboratório de Pesquisas Clínicas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Ferreira GM; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Laboratório de Pesquisas Clínicas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., da Silva GN; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Laboratório de Pesquisas Clínicas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Programa de Pós-Graduação em Ciências Biológicas (CBIOL), Universidade Federal de Ouro Preto, Ouro Preto, Brazil. |
| المصدر: | Natural product research [Nat Prod Res] 2023 Jun; Vol. 37 (11), pp. 1877-1881. Date of Electronic Publication: 2022 Sep 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Urinary Bladder*/metabolism , Urinary Bladder*/pathology , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/genetics, Humans ; Cell Survival ; Flavonoids/pharmacology ; Apoptosis/genetics ; Epigenesis, Genetic ; Cell Line, Tumor |
| مستخلص: | This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different status of TP53 (RT4, 5637 and T24). The cells were treated with different concentrations of chrysin (20, 40, 60, 80 and 100 µM) to analyze the cell viability, nuclear division index, mutagenicity, apoptosis rates and expression of genes related to epigenetic events ( DNMT1 , HAT1 and HDAC1 ). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis, regardless TP53 . Moreover, in the TP53 -mutated cell lines, chrysin modulated the expression of the DNMT1 , HAT1 and HDAC1 epigenetic genes, which might be a plus to the death observed in the cells with p53 mutation. |
| فهرسة مساهمة: | Keywords: Flavonoid; IDN; TP53; bladder tumor; cell death; epigenetic events |
| المشرفين على المادة: | 3CN01F5ZJ5 (chrysin) 0 (Flavonoids) |
| تواريخ الأحداث: | Date Created: 20220912 Date Completed: 20230505 Latest Revision: 20230505 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2022.2121825 |
| PMID: | 36093567 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2022.2121825 |