دورية أكاديمية
أعرض في EDS

Effects of commercial amniotic membrane extract on the re-epithelialization time and the early expression of matrix metalloproteinase-9 in cats with experimentally induced corneal ulcers.

التفاصيل البيبلوغرافية
العنوان: Effects of commercial amniotic membrane extract on the re-epithelialization time and the early expression of matrix metalloproteinase-9 in cats with experimentally induced corneal ulcers.
المؤلفون: Silveira BC; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil., Ribeiro AP; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil., Pizzinatto FD; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil., Lobo PM; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil., Miranda HR; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil., de Assis Pereira N; Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Cuiabá, Brazil.
المصدر: Veterinary ophthalmology [Vet Ophthalmol] 2023 Apr; Vol. 26 Suppl 1, pp. 154-162. Date of Electronic Publication: 2022 Sep 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 100887377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-5224 (Electronic) Linking ISSN: 14635216 NLM ISO Abbreviation: Vet Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Osney Mead, Oxford, UK : Blackwell Science, c1998-
مواضيع طبية MeSH: Corneal Ulcer*/drug therapy , Corneal Ulcer*/veterinary , Keratitis*/veterinary , Corneal Injuries*/veterinary , Cat Diseases*, Cats ; Animals ; Re-Epithelialization ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Amnion/transplantation ; Cornea
مستخلص: Objectives: To investigate whether a commercially available amniotic membrane extract (AME) can accelerate corneal wound healing and suppress the early expression of MMP-9 in the tears of cats with experimentally induced superficial ulcerative keratitis.
Procedures: A total number of 16 cats were included. At the end of keratectomy, cats in the treatment group (TG, n = 8) received 40 μl of AME (EyeQ® Amniotic Eye Drops, Vetrix®) four times daily, while cats in the control group (CG, n = 8) received 40 μl of saline at the same time points. Tears were collected 24 and 48 h after keratectomy, and the total MMP-9 was quantified by ELISA.
Results: The corneal re-epithelialization rate did not differ between groups (p = .26), being 0.48 ± 0.05 mm 2 /h in the CG and 0.41 ± 0.03 mm 2 /h in the TG. Similarly, the average time to achieve corneal wound healing did not differ between groups (p = .25) and was 61.50 ± 3.54 h in the CG and 70.50 ± 6.71 h in the TG. The dimensions of the ulcerated areas also did not differ at any time point between the groups (p > .05). In both groups, corneas healed without scarring, pigmentation, or vascularization. The expression of MMP-9 in the tears was similar in both groups at 24 h post-keratectomy, with a slight decrease at 48 h (p > .05).
Conclusions: The instillation of a commercial AME (EyeQ®) is safe, but it did not decrease the corneal re-epithelialization time or the early expression of MMP-9 in the tears of cats with experimentally induced superficial ulcerative keratitis in this study.
(© 2022 American College of Veterinary Ophthalmologists.)
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معلومات مُعتمدة: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: MMP-9; amnion extract; cat; corneal ulcer; corneal wound healing; feline
المشرفين على المادة: EC 3.4.24.35 (Matrix Metalloproteinase 9)
تواريخ الأحداث: Date Created: 20220912 Date Completed: 20230510 Latest Revision: 20230510
رمز التحديث: 20230512
DOI: 10.1111/vop.13024
PMID: 36094319
قاعدة البيانات: MEDLINE
الوصف
تدمد:1463-5224
DOI:10.1111/vop.13024