دورية أكاديمية
A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans.
| العنوان: | A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans. |
|---|---|
| المؤلفون: | Denham ST; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Brammer B; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Chung KY; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Wambaugh MA; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Bednarek JM; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Guo L; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Moreau CT; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA., Brown JCS; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: jessica.brown@path.utah.edu. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2022 Oct 12; Vol. 30 (10), pp. 1382-1400.e8. Date of Electronic Publication: 2022 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Cryptococcosis*/microbiology , Cryptococcus neoformans*/genetics, Adaptation, Physiological ; Animals ; Columbidae ; Mammals ; Phosphates/metabolism |
| مستخلص: | Environmental pathogens move from ecological niches to mammalian hosts, requiring adaptation to dramatically different environments. Microbes that disseminate farther, including the fungal meningitis pathogen Cryptococcus neoformans, require additional adaptation to diverse tissues. We demonstrate that the formation of a small C. neoformans morphotype-called "seed" cells due to their colonizing ability-is critical for extrapulmonary organ entry. Seed cells exhibit changes in fungal cell size and surface expression that result in an enhanced macrophage update. Seed cell formation is triggered by environmental factors, including C. neoformans' environmental niche, and pigeon guano with phosphate plays a central role. Seed cells show the enhanced expression of phosphate acquisition genes, and mutants unable to acquire phosphate fail to adopt the seed cell morphotype. Additionally, phosphate can be released by tissue damage, potentially establishing a feed-forward loop of seed cell formation and dissemination. Thus, C. neoformans' size variation represent inducible morphotypes that change host interactions to facilitate microbe spread. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Nat Rev Microbiol. 2022 Dec;20(12):703. (PMID: 36175769) Comment in: Cell Host Microbe. 2022 Oct 12;30(10):1341-1342. (PMID: 36228579) |
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| معلومات مُعتمدة: | S10 RR026802 United States RR NCRR NIH HHS; T32 AI055434 United States AI NIAID NIH HHS; R01 AI100272 United States AI NIAID NIH HHS; T32 GM141848 United States GM NIGMS NIH HHS; R01 AI130248 United States AI NIAID NIH HHS; P30 CA042014 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Cryptococcus; environmental reservoir; fungal dissemination; fungal pathogenesis; morphological switch; morphology; mycology; phosphate |
| المشرفين على المادة: | 0 (Phosphates) |
| تواريخ الأحداث: | Date Created: 20220913 Date Completed: 20221017 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| مُعرف محوري في PubMed: | PMC9588642 |
| DOI: | 10.1016/j.chom.2022.08.017 |
| PMID: | 36099922 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2022.08.017 |