دورية أكاديمية
The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells.
| العنوان: | The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells. |
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| المؤلفون: | Quah PS; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Sutton V; Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia., Whitlock E; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Figgett WA; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Andrews DM; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Bioproperties, Ringwood, Melbourne, VIC, Australia., Fairfax KA; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia., Mackay F; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| المصدر: | Immunology and cell biology [Immunol Cell Biol] 2022 Nov; Vol. 100 (10), pp. 761-776. Date of Electronic Publication: 2022 Oct 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8706300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1711 (Electronic) Linking ISSN: 08189641 NLM ISO Abbreviation: Immunol Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : [Hoboken, NJ] : Wiley Original Publication: [Adelaide, South Australia] : University of Adelaide, [c1987- |
| مواضيع طبية MeSH: | Transmembrane Activator and CAML Interactor Protein*/genetics , Lupus Erythematosus, Systemic*, Mice ; Animals ; Population Density ; Interleukin-4 ; Mice, Transgenic ; Killer Cells, Natural/metabolism |
| مستخلص: | The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to innate immunity remain unclear. Natural killer (NK) cells form the first line of defense against viruses and tumors, and have been shown to be defective in patients with systemic lupus erythematosus (SLE). The link between BAFF and NK cells in the development and progression of SLE remains unstudied. By assessing NK cell numbers in wild-type (WT), BAFF -/- (BAFF deficient), BAFF-R -/- (BAFF receptor deficient), TACI -/- (transmembrane activator and calcium modulator and cyclophilin ligand interactor deficient), BCMA -/- (B-cell maturation antigen deficient) and BAFF transgenic (Tg) mice, we observed that BAFF signaling through BAFF-R was essential for sustaining NK cell numbers in the spleen. However, according to the cell surface expression of CD27 and CD11b on NK cells, we found that BAFF was dispensable for NK cell maturation. Ex vivo and in vivo models showed that NK cells from BAFF -/- and BAFF Tg mice produced interferon-γ and killed tumor cells at a level similar to that in WT mice. Finally, we established that NK cells do not express receptors that interact with BAFF in the steady state or in the BAFF Tg mouse model of SLE. Our findings demonstrate that BAFF has an indirect effect on NK cell homeostasis and no effect on NK cell function. (© 2022 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.) |
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| فهرسة مساهمة: | Keywords: Autoimmunity; Cancer; Immunodeficiency; Innate immunity; Natural killer cell |
| المشرفين على المادة: | 0 (Transmembrane Activator and CAML Interactor Protein) 207137-56-2 (Interleukin-4) |
| تواريخ الأحداث: | Date Created: 20220915 Date Completed: 20221115 Latest Revision: 20230111 |
| رمز التحديث: | 20230111 |
| مُعرف محوري في PubMed: | PMC9828838 |
| DOI: | 10.1111/imcb.12585 |
| PMID: | 36106449 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1440-1711 |
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| DOI: | 10.1111/imcb.12585 |