دورية أكاديمية
The effect of probiotics on postsurgical complications in patients with colorectal cancer: a systematic review and meta-analysis.
| العنوان: | The effect of probiotics on postsurgical complications in patients with colorectal cancer: a systematic review and meta-analysis. |
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| المؤلفون: | Araújo MM; Graduate Program in Human Nutrition, Department of Nutrition, University of Brasília, Brasília, Federal District, Brazil., Montalvão-Sousa TM; Graduate Program in Human Nutrition, Department of Nutrition, University of Brasília, Brasília, Federal District, Brazil., Teixeira PDC; Graduate Program in Human Nutrition, Department of Nutrition, University of Brasília, Brasília, Federal District, Brazil., Figueiredo ACMG; Epidemiology Surveillance, Federal District Health State Department, Brasília, Federal District, Brazil., Botelho PB; Graduate Program in Human Nutrition, Department of Nutrition, University of Brasília, Brasília, Federal District, Brazil. |
| المصدر: | Nutrition reviews [Nutr Rev] 2023 Apr 11; Vol. 81 (5), pp. 493-510. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0376405 Publication Model: Print Cited Medium: Internet ISSN: 1753-4887 (Electronic) Linking ISSN: 00296643 NLM ISO Abbreviation: Nutr Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford Oxford University Press Original Publication: [Washington, D.C.] : International Life Sciences Institute |
| مواضيع طبية MeSH: | Probiotics*/therapeutic use , Synbiotics* , Colorectal Neoplasms*/surgery, Humans ; Surgical Wound Infection/prevention & control ; Diarrhea/prevention & control |
| مستخلص: | Context: Clinical trials have investigated the effect of probiotics on postsurgical complications in colorectal cancer (CRC). However, so far, there are no systematic reviews evaluating the effect of probiotics and synbiotics on the clinical or infectious postsurgical complications of colorectal cancer. Objective: The objective of this review was to synthesize the best available evidence on the effects of the use of probiotics or synbiotics on pre-, peri-, and post-operative complications of CRC surgical resection. Data Sources: A search of the PubMed, Embase, LILACS, Scopus, Cochrane, Web of Science, ProQuest, and Google Scholar databases was conducted for clinical trials published up until January 2022. Data Extraction: The population characteristics, period and protocol of supplementation, and postoperative complications were extracted and reported. A random-effects model was used to estimate the effect of probiotic and synbiotic treatment on these variables. Data Synthesis: In total, 2518 studies were identified, of which 16 were included in the qualitative synthesis and 13 in the meta-analysis. Overall, probiotic supplementation reduced the incidence of ileus (odds ratio [OR] = .13, 95% confidence interval [CI]: .02, .78), diarrhea (OR = .32, 95% CI: .15, .69), abdominal collection (OR: .35, 95% CI: .13, .92), sepsis (OR = .41, 95% CI: .22, .80), pneumonia (OR = .39, 95% CI: .19, .83), and surgical site infection (OR = .53, 95% CI: .36, .78). The results of the subgroup analysis indicated that lower dose (<109 colony-forming units), higher duration of supplementation (>14 days), and being administrated ≤5 days before and >10 days after surgery was more effective at reducing the incidence of surgical site infection. Conclusion: Probiotics and synbiotics seem to be a promising strategy for the prevention of postoperative complications after CRC surgery. Larger, high-quality randomized controlled trials are needed to establish the optimal treatment protocol for the use of probiotics and synbiotics in preventing postoperative complications for CRC surgery. (© The Author(s) 2022. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: colorectal cancer; postsurgical complications; probiotic; synbiotic |
| تواريخ الأحداث: | Date Created: 20220915 Date Completed: 20230412 Latest Revision: 20230413 |
| رمز التحديث: | 20230414 |
| DOI: | 10.1093/nutrit/nuac069 |
| PMID: | 36106795 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1753-4887 |
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| DOI: | 10.1093/nutrit/nuac069 |