دورية أكاديمية
أعرض في EDS

The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats.

التفاصيل البيبلوغرافية
العنوان: The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats.
المؤلفون: Engel LE; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., de Souza FLA; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Giometti IC; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Okoshi K; São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil., Mariano TB; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Ferreira NZ; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Pinheiro DG; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Floriano RS; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil., Aguiar AF; University of Northern Paraná (UNOPAR), Londrina, PR 86047-500, Brazil., Cicogna AC; São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil., Vechetti IJ Jr; University of Nebraska-Lincoln, Department of Nutrition and Health Sciences, Lincoln, NE 68583, USA., Pacagnelli FL; University of Western São Paulo (UNOESTE), Presidente Prudente, SP 19.067-175, Brazil. Electronic address: francispacagnelli@unoeste.br.
المصدر: Life sciences [Life Sci] 2022 Nov 01; Vol. 308, pp. 120959. Date of Electronic Publication: 2022 Sep 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
مواضيع طبية MeSH: High-Intensity Interval Training* , Hypertension*/metabolism, Animals ; Blood Pressure/physiology ; Male ; Mitogen-Activated Protein Kinases/metabolism ; Myocardium/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Ventricular Remodeling/physiology
مستخلص: Aim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats.
Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed.
Key Findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT.
Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Hypertension; MAP kinase signaling system; Papillary muscles; Physical exercise
المشرفين على المادة: EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
تواريخ الأحداث: Date Created: 20220915 Date Completed: 20221006 Latest Revision: 20221006
رمز التحديث: 20240628
DOI: 10.1016/j.lfs.2022.120959
PMID: 36108768
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0631
DOI:10.1016/j.lfs.2022.120959