دورية أكاديمية
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Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model.

التفاصيل البيبلوغرافية
العنوان: Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model.
المؤلفون: Williams MT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America.; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America., Sugimoto C; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America., Regan SL; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America., Pitzer EM; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America., Fritz AL; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America., Sertorio M; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America.; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Mascia AE; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America.; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Vatner RE; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America.; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America., Perentesis JP; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America.; Division of Oncology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America., Vorhees CV; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States of America.; Cincinnati Children's/University of Cincinnati Proton Therapy and Research Center, Cincinnati, OH, United States of America.
المصدر: PloS one [PLoS One] 2022 Sep 16; Vol. 17 (9), pp. e0274007. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Brain* , Protons*, Animals ; Cognition ; Maze Learning ; Rats ; Rats, Sprague-Dawley
مستخلص: Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical data are required to demonstrate this sparing effect. In this study, postnatal day 11 (P11) rats were treated with whole brain irradiation with protons at a total dose of 0, 5, or 8 Gy, comparing a conventional dose rate of 1 Gy/s vs. a FLASH dose rate of 100 Gy/s. Beginning on P64, rats were tested for locomotor activity, acoustic and tactile startle responses (ASR, TSR) with or without prepulses, novel object recognition (NOR; 4-object version), striatal dependent egocentric learning ([configuration A] Cincinnati water maze (CWM-A)), prefrontal dependent working memory (radial water maze (RWM)), hippocampal dependent spatial learning (Morris water maze (MWM)), amygdala dependent conditioned freezing, and the mirror image CWM [configuration B (CWM-B)]. All groups had deficits in the CWM-A procedure. Weight reductions, decreased center ambulation in the open-field, increased latency on day-1 of RWM, and deficits in CWM-B were observed in all irradiated groups, except the 5 Gy FLASH group. ASR and TSR were reduced in the 8 Gy FLASH group and day-2 latencies in the RWM were increased in the FLASH groups compared with controls. There were no effects on prepulse trials of ASR or TSR, NOR, MWM, or conditioned freezing. The results suggest striatal and prefrontal cortex are sensitive regions at P11 to proton irradiation, with reduced toxicity from FLASH at 5 Gy.
Competing Interests: These experiments were funded by Varian, a Siemens Healthineers company that granted the authors intellectual freedom to publish the data. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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معلومات مُعتمدة: P30 ES006096 United States ES NIEHS NIH HHS
المشرفين على المادة: 0 (Protons)
تواريخ الأحداث: Date Created: 20220916 Date Completed: 20220920 Latest Revision: 20230329
رمز التحديث: 20230329
مُعرف محوري في PubMed: PMC9481014
DOI: 10.1371/journal.pone.0274007
PMID: 36112695
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0274007