دورية أكاديمية
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Incidence and risk factors for stroke in patients with COVID-19 in the Philippines: An analysis of 10,881 cases.

التفاصيل البيبلوغرافية
العنوان: Incidence and risk factors for stroke in patients with COVID-19 in the Philippines: An analysis of 10,881 cases.
المؤلفون: Jamora RDG; Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines. Electronic address: rgjamora@up.edu.ph., Prado MB Jr; Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Epidemiology and Biostatistics, College of Public Health, University of the Philippines Manila, Manila, Philippines., Anlacan VMM; Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Neurology, Institute of Neurological Sciences, The Medical City, Pasig City, Philippines., Sy MCC; Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., Espiritu AI; Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines; Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
المصدر: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2022 Nov; Vol. 31 (11), pp. 106776. Date of Electronic Publication: 2022 Sep 08.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Saunders Country of Publication: United States NLM ID: 9111633 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8511 (Electronic) Linking ISSN: 10523057 NLM ISO Abbreviation: J Stroke Cerebrovasc Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : Saunders
Original Publication: New York, NY : Demos Publications, [1991-
مواضيع طبية MeSH: COVID-19* , Stroke*/diagnosis , Stroke*/epidemiology , Stroke*/complications, Humans ; Incidence ; Philippines/epidemiology ; Risk Factors ; Retrospective Studies
مستخلص: Background: While most large studies on the possible association of COVID-19 and stroke were done in high-income countries, only a few studies consisting of small sample populations have been done in low- to middle-income countries like the Philippines.
Objectives: To determine the risk factors of stroke among hospitalized COVID19 patients in the Philippines; to determine the possible association between these risk factors and stroke among the same cohort; and to determine if there is an association between mortality and stroke in this same group.
Methodology: We obtained relevant clinical and neurological, including stroke data from the Philippine CORONA study, an observational study involving 10,881 patients with COVID-19 admitted in 37 referral hospitals from all over the Philippines.
Results: The incidence of stroke among patients with COVID-19 was 3.4% (n = 367). There were more deaths among patients with stroke and COVID-19 than those without stroke and COVID-19 (42.2% vs 14.7%, p < 0.01). In addition, more patients with stroke were admitted in the ICU (43.3% vs 15.0%, p < 0.01) regardless of cause. Smoking (OR: 1.5, 95% CI: 1.3 to 1.7, p < 0.0001), hypertension (OR:1.75, 95% CI:1.53 to 1.97, p < 0.0001), presence of heart failure (OR: 1.4, 95% CI: 1.07 to 1.86, p = 0.01), presence of any neurologic co-morbidities (OR: 1.4, 95% CI:1.11 to 1.46, p = 0.004), and history of stroke (OR:2.3, 95% CI:1.82 to 2.97, p < 0.0001) had direct significant correlation with stroke; while being a health care worker (OR: 0.5, 95% CI: 0.33 to 0.70, p < 0.0004) had an inverse significant association with stroke.
Conclusion: COVID-19 stroke patients in the Philippines have a higher mortality and ICU admission rates than patients with COVID-19 alone or COVID-19 stroke patients from developed countries. Our cohort has similar cardiovascular and metabolic risk factors to western patients with stroke, highlighting that COVID-19 may only have a small contribution to stroke incidence.
Competing Interests: Declaration of Competing Interest We declare no competing interests.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: Acute hemorrhagic stroke; Acute ischemic stroke; COVID-19; Low-to-middle-income countries; Risk factors
تواريخ الأحداث: Date Created: 20220916 Date Completed: 20221026 Latest Revision: 20221221
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9452414
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106776
PMID: 36113391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2022.106776