دورية أكاديمية
TGFβ priming promotes TNF-induced bone erosion: a promising new target in RA?
| العنوان: | TGFβ priming promotes TNF-induced bone erosion: a promising new target in RA? |
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| المؤلفون: | Yao Z; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. zhenqiang_yao@urmc.rochester.edu., Boyce BF; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. |
| المصدر: | Nature reviews. Rheumatology [Nat Rev Rheumatol] 2022 Nov; Vol. 18 (11), pp. 617-618. |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101500080 Publication Model: Print Cited Medium: Internet ISSN: 1759-4804 (Electronic) Linking ISSN: 17594790 NLM ISO Abbreviation: Nat Rev Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Group |
| مواضيع طبية MeSH: | Transforming Growth Factor beta* , Arthritis, Rheumatoid*/drug therapy, Humans ; Osteoclasts |
| التعليقات: | Comment on: Nat Commun. 2022 Jul 7;13(1):3920. (PMID: 35798734) |
| References: | Yao, Z., Getting, S. J. & Locke, I. C. Regulation of TNF-induced osteoclast differentiation. Cells 11, 132 (2021). (PMID: 10.3390/cells11010132) Xia, Y. et al. TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis. Nat. Commun. 13, 3920 (2022). (PMID: 10.1038/s41467-022-31475-1) Takeuchi, T. et al. Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial. Ann. Rheum. Dis. 78, 899–907 (2019). (PMID: 10.1136/annrheumdis-2018-214827) Genovese, M. C. et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum. 50, 1412–1419 (2004). (PMID: 10.1002/art.20221) Lettesjo, H. et al. Synovial fluid cytokines in patients with rheumatoid arthritis or other arthritic lesions. Scand. J. Immunol. 48, 286–292 (1998). (PMID: 10.1046/j.1365-3083.1998.00399.x) Tang, Y. et al. TGF-β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat. Med. 15, 757–765 (2009). (PMID: 10.1038/nm.1979) Oh, S. A. & Li, M. O. TGF-β: guardian of T cell function. J. Immunol. 191, 3973–3979 (2013). (PMID: 10.4049/jimmunol.1301843) Shen J, et al. Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum. 65, 3107–3119 (2013). (PMID: 10.1002/art.38122) Li, J. et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat. Commun. 10, 2795 (2019). (PMID: 10.1038/s41467-019-10677-0) Akhurst, R. J. & Hata, A. Targeting the TGFβ signalling pathway in disease. Nat. Rev. Drug Discov. 11, 790–811 (2012). (PMID: 10.1038/nrd3810) |
| معلومات مُعتمدة: | R01 AG049994 United States AG NIA NIH HHS |
| المشرفين على المادة: | 0 (Transforming Growth Factor beta) |
| تواريخ الأحداث: | Date Created: 20220916 Date Completed: 20221027 Latest Revision: 20231116 |
| رمز التحديث: | 20231116 |
| DOI: | 10.1038/s41584-022-00843-y |
| PMID: | 36114427 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1759-4804 |
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| DOI: | 10.1038/s41584-022-00843-y |