دورية أكاديمية
Clozapine as a treatment for catatonia: A systematic review.
| العنوان: | Clozapine as a treatment for catatonia: A systematic review. |
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| المؤلفون: | Saini A; Medical School, University College London, London, UK. Electronic address: aman.saini.18@ucl.ac.uk., Begum N; King's College Hospital, London, UK., Matti J; Medical School, University College London, London, UK., Ghanem DA; Medical School, University College London, London, UK., Fripp L; Medical School, University College London, London, UK., Pollak TA; Department of Psychosis Studies, King's College London, London, UK., Zandi MS; UCL Queen Square Institute of Neurology, University College London, London, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK., David A; Institute of Mental Health, University College London, London, UK., Lewis G; Division of Psychiatry, University College London, London, UK., Rogers J; Division of Psychiatry, University College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK. |
| المصدر: | Schizophrenia research [Schizophr Res] 2024 Jan; Vol. 263, pp. 275-281. Date of Electronic Publication: 2022 Sep 15. |
| نوع المنشور: | Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: | Clozapine*/therapeutic use , Catatonia*/diagnosis , Antipsychotic Agents*/therapeutic use , Schizophrenia*/drug therapy , Schizophrenia*/complications , Neuroleptic Malignant Syndrome*/etiology, Humans |
| مستخلص: | Catatonia is a neuropsychiatric disorder characterised by altered movement, speech, and behaviour. Clozapine is an established therapy for treatment-resistant schizophrenia, but its role in catatonia has not been systematically examined. In this systematic review, we aimed to assess the evidence for clozapine as a treatment for catatonia. Full text original research articles in English where at least one patient with catatonia was treated with clozapine were included, provided catatonia did not occur solely in the context of neuroleptic malignant syndrome. Results were tabulated with calculations of summary statistics presented. Risk of bias was assessed with the Tool for Evaluating the Methodological Quality of Case Reports and Case Series. 182 patients were included, 81 from cohort studies and 101 from case reports or case series. 119/182 patients (65 %) had a specified underlying diagnosis of schizophrenia. Over 80 % of reported patients with catatonia had at least partial remission following treatment with clozapine across both cohort studies and case reports and case series. Among the case reports and series, 24/101 patients (23.8 %) followed clozapine withdrawal. Overall, 25 studies were of low quality, 60 of moderate quality and 8 of high quality. Our findings should be interpreted with caution, as the reliance on case reports, case series and small cohort studies is susceptible to reporting biases, regression to the mean and confounding by other treatments. Future research could use large healthcare databases to ascertain outcomes in those on clozapine with a history of catatonia given the difficulty and expense of conducting randomised controlled trials. Competing Interests: Declaration of competing interest The funders had no role in the design, analysis, or decision to publish. MZ has received honoraria for a lecture from Eisai. (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Catatonia; Catatonic schizophrenia; Clozapine; Systematic review; Treatment |
| المشرفين على المادة: | J60AR2IKIC (Clozapine) 0 (Antipsychotic Agents) |
| تواريخ الأحداث: | Date Created: 20220918 Date Completed: 20231222 Latest Revision: 20231222 |
| رمز التحديث: | 20231222 |
| DOI: | 10.1016/j.schres.2022.09.021 |
| PMID: | 36117082 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1573-2509 |
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| DOI: | 10.1016/j.schres.2022.09.021 |