دورية أكاديمية
The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort.
| العنوان: | The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort. |
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| المؤلفون: | Babayigit C; Department of Pulmonary Medicine, Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey., Kokturk N; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey., Kul S; Department of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey., Cetinkaya PD; Department of Pulmonary Medicine, Adana City Training and Research Hospital, University of Health Sciences, Adana, Turkey.; Department of Pulmonary Medicine, Faculty of Medicine, Çukurova University, Adana, Turkey., Atis Nayci S; Department of Pulmonary Medicine, Faculty of Medicine, Mersin University, Yenişehir, Turkey., Argun Baris S; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey., Karcioglu O; Department of Pulmonary Medicine, Halil Şıvgın Cubuk State Hospital, Ankara, Turkey., Aysert P; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey., Irmak I; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Akbas Yuksel A; Department of Pulmonary Medicine, Faculty of Medicine, Ufuk University, Ankara, Turkey., Sekibag Y; Department of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Baydar Toprak O; Department of Pulmonary Medicine, Faculty of Medicine, Çukurova University, Adana, Turkey., Azak E; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Kocaeli University, İzmit, Turkey., Mulamahmutoglu S; Department of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Cuhadaroglu C; Department of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey., Demirel A; Department of Infectious Disease, Kadıköy Florence Nightingale Hospital, Istanbul, Turkey., Kerget B; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey., Baran Ketencioglu B; Department of Pulmonary Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Ozger HS; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey., Ozkan G; Department of Pulmonary Medicine, Acibadem Maslak Hospital, Istanbul, Turkey.; Operating Room Services Department, Vocational School, Nişantaşı University, Istanbul, Turkey., Ture Z; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Ergan B; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey., Avkan Oguz V; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey., Kilinc O; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey., Ercelik M; Department of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey., Ulukavak Ciftci T; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey., Alici O; Department of Infectious Disease, Turkiye Gazetesi Private Hospital, Istanbul, Turkey., Nurlu Temel E; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Ataoglu O; Department of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey., Aydin A; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey., Cetiner Bahcetepe D; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey., Gullu YT; Department of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey., Fakili F; Department of Pulmonary Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey., Deveci F; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazıg˘, Turkey., Kose N; Department of Pulmonary Medicine, Bilecik Training and Research Hospital, Bilecik, Turkey., Tor MM; Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey., Gunluoglu G; Department of Pulmonary Medicine, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, University of Health Science, Istanbul, Turkey., Altin S; Department of Pulmonary Medicine, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, University of Health Science, Istanbul, Turkey., Turgut T; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazıg˘, Turkey., Tuna T; Department of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey., Ozturk O; Department of Pulmonary Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey., Dikensoy O; Department of Pulmonary Medicine, Faculty of Medicine, Taksim, Acibadem University, Istanbul, Turkey., Yildiz Gulhan P; Department of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey., Basyigit I; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey., Boyaci H; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey., Oguzulgen IK; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey., Borekci S; Department of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Gemicioglu B; Department of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Bayraktar F; Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey., Elbek O; Department of Pulmonary Medicine, Kadıköy Florence Nightingale Hospital, Istanbul, Turkey., Hanta I; Department of Pulmonary Medicine, Faculty of Medicine, Çukurova University, Adana, Turkey., Kuzu Okur H; Department of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey., Sagcan G; Department of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey., Uzun O; Department of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey., Akgun M; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey., Altinisik G; Department of Pulmonary Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey., Dursun B; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey., Cakir Edis E; Department of Pulmonary Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey., Gulhan E; Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey., Oner Eyuboglu F; Department of Pulmonary Medicine, School of Medicine, Başkent University, Ankara, Turkey., Gultekin O; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey., Havlucu Y; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey., Ozkan M; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey., Sakar Coskun A; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey., Sayiner A; Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir, Turkey., Kalyoncu AF; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Itil O; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey., Bayram H; Department of Pulmonary Medicine, Koç University School of Medicine, Istanbul, Turkey.; Koç University Research Center for Translational Medicine (KUTTAM), Koç University School of Medicine, Istanbul, Turkey. |
| المصدر: | Frontiers in medicine [Front Med (Lausanne)] 2022 Aug 31; Vol. 9, pp. 894126. Date of Electronic Publication: 2022 Aug 31 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]- |
| مستخلص: | Background and Objectives: Although several repurposed antiviral drugs have been used for the treatment of COVID-19, only a few such as remdesivir and molnupiravir have shown promising effects. The objectives of our study were to investigate the association of repurposed antiviral drugs with COVID-19 morbidity. Methods: Patients admitted to 26 different hospitals located in 16 different provinces between March 11-July 18, 2020, were enrolled. Case definition was based on WHO criteria. Patients were managed according to the guidelines by Scientific Board of Ministry of Health of Turkey. Primary outcomes were length of hospitalization, intensive care unit (ICU) requirement, and intubation. Results: We retrospectively evaluated 1,472 COVID-19 adult patients; 57.1% were men (mean age = 51.9 ± 17.7years). A total of 210 (14.3%) had severe pneumonia, 115 (7.8%) were admitted to ICUs, and 69 (4.7%) were intubated during hospitalization. The median (interquartile range) of duration of hospitalization, including ICU admission, was 7 (5-12) days. Favipiravir ( n = 328), lopinavir/ritonavir ( n = 55), and oseltamivir ( n = 761) were administered as antiviral agents, and hydroxychloroquine (HCQ, n = 1,382) and azithromycin ( n = 738) were used for their immunomodulatory activity. Lopinavir/ritonavir (β [95% CI]: 4.71 [2.31-7.11]; p = 0.001), favipiravir (β [95% CI]: 3.55 [2.56-4.55]; p = 0.001) and HCQ (β [95% CI]: 0.84 [0.02-1.67]; p = 0.046) were associated with increased risk of lengthy hospital stays. Furthermore, favipiravir was associated with increased risks of ICU admission (OR [95% CI]: 3.02 [1.70-5.35]; p = 0.001) and invasive mechanical ventilation requirement (OR [95% CI]: 2.94 [1.28-6.75]; p = 0.011). Conclusion: Our findings demonstrated that antiviral drugs including lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes such as increased risks for lengthy hospital stay, ICU admission, and invasive mechanical ventilation requirement. Therefore, repurposing such agents without proven clinical evidence might not be the best approach for COVID-19 treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer BH declared a shared affiliation with the authors, II and AK to the handling editor at the time of review. (Copyright © 2022 Babayigit, Kokturk, Kul, Cetinkaya, Atis Nayci, Argun Baris, Karcioglu, Aysert, Irmak, Akbas Yuksel, Sekibag, Baydar Toprak, Azak, Mulamahmutoglu, Cuhadaroglu, Demirel, Kerget, Baran Ketencioglu, Ozger, Ozkan, Ture, Ergan, Avkan Oguz, Kilinc, Ercelik, Ulukavak Ciftci, Alici, Nurlu Temel, Ataoglu, Aydin, Cetiner Bahcetepe, Gullu, Fakili, Deveci, Kose, Tor, Gunluoglu, Altin, Turgut, Tuna, Ozturk, Dikensoy, Yildiz Gulhan, Basyigit, Boyaci, Oguzulgen, Borekci, Gemicioglu, Bayraktar, Elbek, Hanta, Kuzu Okur, Sagcan, Uzun, Akgun, Altinisik, Dursun, Cakir Edis, Gulhan, Oner Eyuboglu, Gultekin, Havlucu, Ozkan, Sakar Coskun, Sayiner, Kalyoncu, Itil and Bayram.) |
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| فهرسة مساهمة: | Keywords: COVID-19 morbidity; ICU requirement; antiviral agents; invasive mechanical ventilation; length of hospitalization |
| تواريخ الأحداث: | Date Created: 20220919 Latest Revision: 20220920 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9471091 |
| DOI: | 10.3389/fmed.2022.894126 |
| PMID: | 36117966 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-858X |
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| DOI: | 10.3389/fmed.2022.894126 |