دورية أكاديمية
أعرض في EDS

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice.

التفاصيل البيبلوغرافية
العنوان: Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice.
المؤلفون: Chou MY; International Aging Industry Research & Development Center (AIC), Providence University, Taichung, Taiwan., Ho JH; Department of Food Science, Tunghai University, Taichung, Taiwan., Huang MJ; School of General Education, Hsiuping University of Science and Technology, Taichung, Taiwan., Chen YJ; Ph.D. Program in Health and Social Welfare for Indigenous Peoples, Providence University, Taichung, Taiwan., Yang MD; Department of Surgery, Department of Clinical Nutrition, China Medical University Hospital, Taichung, Taiwan., Lin LH; Division of Allergy, Immunology & Rheumatology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan., Chi CH; International Aging Industry Research & Development Center (AIC), Providence University, Taichung, Taiwan., Yeh CH; Taiwan Chlorella Manufacturing Co., Ltd., Taipei, Taiwan., Tsao TY; Taiwan Chlorella Manufacturing Co., Ltd., Taipei, Taiwan., Tzeng JK; Taiwan Chlorella Manufacturing Co., Ltd., Taipei, Taiwan., Hsu RJ; China Grain Products Research and Development Institute, New Taipei, Taiwan., Huang PH; College of Food, Jiangsu Food and Pharmaceutical Science College, Huai'an City, China., Lu WC; Department of Food and Beverage Management, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi City, Taiwan., Li PH; Department of Food and Nutrition, Providence University, Taichung, Taiwan., Wang MF; International Aging Industry Research & Development Center (AIC), Providence University, Taichung, Taiwan.; Department of Food and Nutrition, Providence University, Taichung, Taiwan.
المصدر: Frontiers in nutrition [Front Nutr] 2022 Sep 02; Vol. 9, pp. 977287. Date of Electronic Publication: 2022 Sep 02 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]-
مستخلص: Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural materials is an urgent need. Therefore, this study used a complex extract of chlorella and lion's mane mushroom and evaluated its antidepressant effects. Six-month-old male senescence-accelerated mice prone-8 (SAMP8) were divided into positive control; negative control; and low, medium, and high-dose groups. All groups were treated with corticosterone (CORT) at 40 mg/Kg/day for 21- days to induce depression in the animals, and the effects of different test substances on animal behavior was observed. The positive control group was intraperitoneally injected with a tricyclic antidepressant (Fluoxetine, as tricyclic antidepressant), the control group was given ddH 2 O, and the test substance groups were administered test samples once daily for 21 days. The open field test (OFT) and forced swimming test (FST) were applied for behavior analyses of depression animal models. The OFT results showed that the mice in the positive control and the medium-, and high-dose groups demonstrated a significantly prolonged duration in the central area and a significantly increased travel distance. In the FST, the positive control and the medium, and high-dose groups displayed significantly reduced immobility times relative to the control group. The blood analysis results showed significant decreases in triglyceride and blood urea nitrogen levels relative to the positive control and the medium- and high-dose groups. Notably, in the positive control and the medium- and high-dose groups, brain-derived neurotrophic factor (BDNF) increase by more than in the control group. In summary, medium and high dose of extract of chlorella and lion's mane mushroom could improve depression behavior in animals and have the potential to be antidepressant health care products.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Chou, Ho, Huang, Chen, Yang, Lin, Chi, Yeh, Tsao, Tzeng, Hsu, Huang, Lu, Li and Wang.)
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فهرسة مساهمة: Keywords: antidepressant; chlorella; dietary supplement; lion's mane mushrooms; senescence accelerated mouse prone-8 (SAMP8)
تواريخ الأحداث: Date Created: 20220919 Latest Revision: 20220920
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9479623
DOI: 10.3389/fnut.2022.977287
PMID: 36118772
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-861X
DOI:10.3389/fnut.2022.977287