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In Vitro α -Glycosidase Inhibition and In Silico Studies of Flavonoids Isolated from Pistacia integerrima Stew ex Brandis.

التفاصيل البيبلوغرافية
العنوان: In Vitro α -Glycosidase Inhibition and In Silico Studies of Flavonoids Isolated from Pistacia integerrima Stew ex Brandis.
المؤلفون: Hemeg HA; Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, P.O. Box 344, Al-Madinah Al-Monawra 41411, Saudi Arabia., Rauf A; Department of Chemistry, University of Swabi, Swabi, Anbar, 23430 Khyber Pakhtunkhwa (KP), Pakistan., Rashid U; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan., Muhammad N; Department of Pharmacy, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa (KP), Pakistan., Al-Awthan YS; Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71421, Saudi Arabia.; Department of Biology, Faculty of Science, Ibb University, Ibb 70270, Yemen., Bahattab OS; Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71421, Saudi Arabia., Al-Duais MA; Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71421, Saudi Arabia.; Biochemistry Unit, Chemistry Department, Faculty of Science, Ibb University, Ibb 70270, Yemen., Shah SUA; Department of Pharmacy, University of Swabi, Swabi, Anbar, 23430 Khyber Pakhtunkhwa (KP), Pakistan.
المصدر: BioMed research international [Biomed Res Int] 2022 Sep 09; Vol. 2022, pp. 9636436. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Flavanones*/chemistry , Flavanones*/pharmacology , Pistacia*/chemistry, Flavonoids/chemistry ; Flavonoids/pharmacology ; Glycoside Hydrolases ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
مستخلص: The galls of Pistacia integerrima are used in folk medicine for curing diabetes. The main aim of this study was the purification of flavonoids from galls of P. integerrima. The methanolic extract was subjected to column chromatographic analysis which afforded six flavonoids, namely, 3,5,7,4'-tetrahydroxy-flavanone (1), naringenin (2), 3,5,4'-trihydroxy,7-methoxy-flavanone (3), sakuranetin (4), spinacetin (5), and patuletin (6). These isolated compounds (1-6) were tested against α -glycosidase. The maximum antagonistic effect was noted against compound 6 (97.65%) followed by compound 5 (90.42%) and compound 1 (90.01%) at the same concentration (0.2  μ g). The inhibitory potential of all tested compounds was significant with a degree of variation from each other. Docking studies showed that all studied compounds interact with the active site residues via hydrogen bond interactions with hydroxyl groups, and thus, inhibition was enhanced. Hence, this finding would be the first screening of isolated flavonoids for α -glycosidase activity and with the mechanism of action. These flavonoids should be further investigated as candidate drugs for combating diabetes mellitus.
Competing Interests: The authors declare that they have no potential competing interests.
(Copyright © 2022 Hassan A. Hemeg et al.)
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المشرفين على المادة: 0 (Flavanones)
0 (Flavonoids)
0 (Plant Extracts)
EC 3.2.1.- (Glycoside Hydrolases)
تواريخ الأحداث: Date Created: 20220919 Date Completed: 20220920 Latest Revision: 20220920
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9481312
DOI: 10.1155/2022/9636436
PMID: 36119934
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2022/9636436