دورية أكاديمية
African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.
| العنوان: | African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. |
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| المؤلفون: | Martini R; Department of Surgery, Weill Cornell Medical College, New York, New York.; Department of Genetics, University of Georgia, Athens, Georgia., Delpe P; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, New York., Chu TR; New York Genome Center, New York, New York., Arora K; New York Genome Center, New York, New York., Lord B; Department of Surgery, Weill Cornell Medical College, New York, New York.; Department of Genetics, University of Georgia, Athens, Georgia., Verma A; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, New York., Bedi D; Department of Biomedical Sciences, Tuskegee University, Tuskegee, Alabama., Karanam B; Department of Biology, Tuskegee University, Tuskegee, Alabama., Elhussin I; Center for Cancer Research, Tuskegee University, Tuskegee, Alabama., Chen Y; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan., Gebregzabher E; Department of Biochemistry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Oppong JK; Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adjei EK; Department of Pathology, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Jibril Suleiman A; Department of Pathology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Awuah B; Directorate of Oncology, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Muleta MB; Department of Surgery, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Abebe E; Department of Surgery, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Kyei I; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Aitpillah FS; Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Adinku MO; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ankomah K; Directorate of Radiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Osei-Bonsu EB; Directorate of Oncology, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Chitale DA; Department of Pathology, Henry Ford Health System, Detroit, Michigan., Bensenhaver JM; Department of Surgery, Henry Ford Health System, Detroit, Michigan., Nathanson DS; Department of Surgery, Henry Ford Health System, Detroit, Michigan., Jackson L; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan., Petersen LF; Department of Surgery, Henry Ford Health System, Detroit, Michigan., Proctor E; Department of Surgery, Henry Ford Health System, Detroit, Michigan., Stonaker B; Department of Surgery, Weill Cornell Medical College, New York, New York., Gyan KK; Department of Surgery, Weill Cornell Medical College, New York, New York., Gibbs LD; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, California., Monojlovic Z; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, California., Kittles RA; Department of Population Sciences, City of Hope, Duarte, California., White J; Department of Biology, Tuskegee University, Tuskegee, Alabama., Yates CC; Center for Cancer Research, Tuskegee University, Tuskegee, Alabama., Manne U; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama., Gardner K; Department of Pathology and Cell Biology, Columbia University, New York, New York., Mongan N; Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.; Department of Pharmacology, Weill Cornell Medical College, New York, New York., Cheng E; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York., Ginter P; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York., Hoda S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, New York.; Institute of Computational Biomedicine, Weill Cornell Medical College, New York, New York., Robine N; New York Genome Center, New York, New York., Sboner A; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York., Carpten JD; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, California., Newman L; Department of Surgery, Weill Cornell Medical College, New York, New York., Davis MB; Department of Surgery, Weill Cornell Medical College, New York, New York.; Department of Genetics, University of Georgia, Athens, Georgia.; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, New York.; New York Genome Center, New York, New York.; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan. |
| المصدر: | Cancer discovery [Cancer Discov] 2022 Nov 02; Vol. 12 (11), pp. 2530-2551. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research |
| مواضيع طبية MeSH: | Triple Negative Breast Neoplasms*/genetics, Humans ; Female ; Transcriptome ; Black or African American/genetics ; Biology |
| مستخلص: | Women of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including higher prevalence of basal-like and quadruple-negative subtypes in African Americans (AA). However, previous investigations relied on self-reported race (SRR) of primarily U.S. populations. Due to heterogeneous genetic admixture and biological consequences of social determinants, the true association of African ancestry with TNBC biology is unclear. To address this, we conducted RNA sequencing on an international cohort of AAs, as well as West and East Africans with TNBC. Using comprehensive genetic ancestry estimation in this African-enriched cohort, we found expression of 613 genes associated with African ancestry and 2,000+ associated with regional African ancestry. A subset of African-associated genes also showed differences in normal breast tissue. Pathway enrichment and deconvolution of tumor cellular composition revealed that tumor-associated immunologic profiles are distinct in patients of African descent. Significance: Our comprehensive ancestry quantification process revealed that ancestry-associated gene expression profiles in TNBC include population-level distinctions in immunologic landscapes. These differences may explain some differences in race-group clinical outcomes. This study shows the first definitive link between African ancestry and the TNBC immunologic landscape, from an African-enriched international multiethnic cohort. See related commentary by Hamilton et al., p. 2496. This article is highlighted in the In This Issue feature, p. 2483. (©2022 The Authors; Published by the American Association for Cancer Research.) |
| التعليقات: | Comment in: Cancer Discov. 2022 Nov 2;12(11):2496-2497. doi: 10.1158/2159-8290.CD-22-0852. (PMID: 36321309) |
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| معلومات مُعتمدة: | U54 CA118623 United States CA NCI NIH HHS; L60 MD002419 United States MD NIMHD NIH HHS; 5U54CA118948 National Cancer Institute (NCI); U54-MD007585-26 National Institute on Minority Health and Health Disparities (NIMHD); U54 MD007585 United States MD NIMHD NIH HHS; SC1 GM136521 United States GM NIGMS NIH HHS; R01 CA259396-01 National Cancer Institute (NCI); R01 CA259396 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20220919 Date Completed: 20221103 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC9627137 |
| DOI: | 10.1158/2159-8290.CD-22-0138 |
| PMID: | 36121736 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2159-8290 |
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| DOI: | 10.1158/2159-8290.CD-22-0138 |