دورية أكاديمية
In utero and lactational exposure to methylmercury elicits physical-chemical and morphological damages in the alveolar bone of offspring rats: The first toxicological findings.
| العنوان: | In utero and lactational exposure to methylmercury elicits physical-chemical and morphological damages in the alveolar bone of offspring rats: The first toxicological findings. |
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| المؤلفون: | Chemelo VS; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Nascimento PC; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Bittencourt LO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Souza-Monteiro D; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Balbinot GS; Dental Material Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Albuquerque ARL; Institute of Geosciences, Federal University of Pará, Belém, Brazil., Silva MCF; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., da Paz SPA; Institute of Geosciences, Federal University of Pará, Belém, Brazil., Angélica RS; Institute of Geosciences, Federal University of Pará, Belém, Brazil., Prado AF; Cardiovascular System Pharmacology and Toxicology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belem, Brazil., Martins MD; Faculty of Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Collares FM; Dental Material Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Crespo-Lopez ME; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Para, Belém, Brazil., Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil. Electronic address: rafalima@ufpa.br. |
| المصدر: | Chemosphere [Chemosphere] 2022 Dec; Vol. 308 (Pt 3), pp. 136453. Date of Electronic Publication: 2022 Sep 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Environmental Pollutants* , Mercury* , Methylmercury Compounds*/toxicity, Animals ; Child ; Collagen ; Female ; Humans ; Lactation ; Pregnancy ; Rats |
| مستخلص: | Methylmercury (MeHg) is the most common organic form of mercury (Hg) that humans are exposed and is considered an environmental pollutant. Several populations that live in endemic regions of MeHg exposure are subject to the toxicant for long periods, including pregnant women and children, causing damage to several organs during early periods of development. Alveolar bone is an essential structure for the oral cavity, responsible for supporting teeth and masticatory forces. However, evidence on the effects of MeHg on alveolar bone and the intrauterine and lactation period is lacking. Thus, this study aimed to investigate the effects of MeHg exposure during gestation and lactation on the developing alveolar bone of offspring rats after maternal exposure. Dams were exposed during 41 days of pregnancy and lactation, and the mandibles of the offspring were collected. The alveolar bone was analyzed by Fourier Transform Infrared Spectroscopy to evaluate the physicochemical composition; by Scanning Electron Microscopy for ultrastructural evaluation; by histopathological, histochemical, and morphometric for tissue analyses. In addition, bone quality was assessed by X-ray microtomography. MeHg exposure altered the mineral composition and caused histological damage associated with a lower quantity and thickness of bone trabeculae, as well as reduced osteocyte density and collagen fiber content. A reduction in trabecular thickness and bone volume and an increase in trabecular spaces were observed and were associated with anatomical compromise of the vertical bone dimensions. Thus, the results suggest that the developing alveolar bone is susceptible to the toxic effects of MeHg when organisms are exposed during intrauterine and lactation periods. From a translational perspective, these changes in the alveolar bone can help us understand possible abnormalities induced by toxic metals and highlight the need for care for structures other than those already seen as targets for damage triggered by environmental MeHg exposure. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alveolar bone; Development; Methylmercury; Offspring; Toxicity |
| المشرفين على المادة: | 0 (Environmental Pollutants) 0 (Methylmercury Compounds) 9007-34-5 (Collagen) FXS1BY2PGL (Mercury) |
| تواريخ الأحداث: | Date Created: 20220919 Date Completed: 20221007 Latest Revision: 20221011 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.chemosphere.2022.136453 |
| PMID: | 36122745 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2022.136453 |