دورية أكاديمية
Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI versus Elemental Mass Spectrometry.
| العنوان: | Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI versus Elemental Mass Spectrometry. |
|---|---|
| المؤلفون: | Hua N; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Minaeva O; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Lupoli N; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Franz ES; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Liu X; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Moncaster JA; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Babcock KJ; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Jara H; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Tripodis Y; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Guermazi A; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Soto JA; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Anderson SW; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass., Goldstein LE; From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass. |
| المصدر: | Radiology [Radiology] 2023 Jan; Vol. 306 (1), pp. 244-251. Date of Electronic Publication: 2022 Sep 20. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Radiological Society of North America Country of Publication: United States NLM ID: 0401260 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-1315 (Electronic) Linking ISSN: 00338419 NLM ISO Abbreviation: Radiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Easton, PA : Radiological Society of North America Original Publication: [Illinois?] : Radiological Society of North America, [1923]- |
| مواضيع طبية MeSH: | Gadolinium* , Organometallic Compounds*, Rats ; Female ; Animals ; Rats, Sprague-Dawley ; Gadolinium DTPA ; Contrast Media ; Meglumine ; Magnetic Resonance Imaging/methods ; Brain ; Mass Spectrometry |
| مستخلص: | Background T1-weighted MRI and quantitative longitudinal relaxation rate (R1) mapping have been used to evaluate gadolinium retention in the brain after gadolinium-based contrast agent (GBCA) administration. Whether MRI measures accurately reflect gadolinium regional distribution and concentration in the brain remains unclear. Purpose To compare gadolinium retention in rat forebrain measured with in vivo quantitative MRI R1 and ex vivo laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) mapping after gadobenate, gadopentetate, gadodiamide, or gadobutrol administration. Materials and Methods Adult female Sprague-Dawley rats were randomly assigned to one of five groups (eight per group) and administered gadobenate, gadopentetate, gadodiamide, gadobutrol (2.4 mmol/kg per week for 5 weeks), or saline (4.8 mL/kg per week for 5 weeks). MRI R1 mapping was performed at baseline and 1 week after the final injection to determine R1 and ΔR1. Postmortem brains from the same rats were analyzed with LA-ICP-MS elemental mapping to determine regional gadolinium concentrations. Student t tests were performed to compare results between GBCA and saline groups. Results Rats that were administered gadobenate showed gadolinium-related MRI ΔR1 in 39.5% of brain volume (ΔR1 = 0.087 second -1 ± 0.051); gadopentetate, 20.6% (ΔR1 = 0.069 second -1 ± 0.018); gadodiamide, 5.4% (ΔR1 = 0.055 second -1 ± 0.019); and gadobutrol, 2.2% (ΔR1 = 0.052 second -1 ± 0.041). Agent-specific gadolinium-related ΔR1 was detected in multiple forebrain regions (neocortex, hippocampus, dentate gyrus, thalamus, and caudate-putamen) in rats treated with gadobenate or gadopentetate, whereas rats treated with gadodiamide showed gadolinium-related ΔR1 in caudate-putamen. By contrast, LA-ICP-MS elemental mapping showed a similar regional distribution pattern of heterogeneous retained gadolinium in the forebrain of rats treated with gadobenate, gadopentetate, or gadodiamide, with the average gadolinium concentration of 0.45 μg · g -1 ± 0.07, 0.50 μg · g -1 ± 0.10, and 0.60 μg · g -1 ± 0.11, respectively. Low levels (0.01 μg · g -1 ± 0.00) of retained gadolinium were detected in the forebrain of gadobutrol-treated rats. Conclusion Differences in in vivo MRI longitudinal relaxation rate versus ex vivo elemental mass spectrometry measures of retained gadolinium in rat forebrains suggest that some forms of retained gadolinium may escape detection with MRI. © RSNA, 2022 Online supplemental material is available for this article. |
| References: | Magn Reson Imaging. 2006 Sep;24(7):877-87. (PMID: 16916705) Radiology. 2017 Dec;285(3):839-849. (PMID: 28873047) Chem Rev. 1999 Sep 8;99(9):2293-352. (PMID: 11749483) Invest Radiol. 2017 Jul;52(7):396-404. (PMID: 28125438) Radiology. 2017 Nov;285(2):546-554. (PMID: 28653860) Radiology. 2015 Jul;276(1):228-32. (PMID: 25942417) AJR Am J Roentgenol. 2009 Oct;193(4):1124-7. (PMID: 19770337) Radiology. 2015 Jun;275(3):772-82. (PMID: 25742194) J Magn Reson Imaging. 2009 Dec;30(6):1249-58. (PMID: 19938037) Fundam Clin Pharmacol. 2006 Dec;20(6):563-76. (PMID: 17109649) Neuroimage. 2002 Nov;17(3):1587-98. (PMID: 12414297) Radiology. 2020 Feb;294(2):377-385. (PMID: 31769744) Sci Rep. 2021 Jul 6;11(1):13950. (PMID: 34230532) Radiology. 2017 Apr;283(1):195-204. (PMID: 27797676) Radiology. 2018 Feb;286(2):471-482. (PMID: 28846495) Radiology. 2014 Mar;270(3):834-41. (PMID: 24475844) Biometals. 2016 Jun;29(3):365-76. (PMID: 27053146) Invest Radiol. 2015 Aug;50(8):473-80. (PMID: 26107651) Biometals. 2008 Aug;21(4):469-90. (PMID: 18344005) Radiology. 2018 Nov;289(2):517-534. (PMID: 30204075) Radiology. 2018 Aug;288(2):424-433. (PMID: 29786486) J Trace Elem Med Biol. 2018 Jan;45:125-130. (PMID: 29173468) Magn Reson Imaging. 2009 Sep;27(7):895-906. (PMID: 19520539) Invest Radiol. 2017 Jun;52(6):324-333. (PMID: 28323657) Acta Neuropathol. 2018 Jul;136(1):127-138. (PMID: 29748901) Front Neuroinform. 2011 Nov 24;5:26. (PMID: 22275894) Invest Radiol. 2014 Oct;49(10):685-90. (PMID: 24872007) Neuroimage. 2004;23 Suppl 1:S208-19. (PMID: 15501092) Invest Radiol. 2018 Sep;53(9):518-528. (PMID: 29985204) Invest Radiol. 2018 Sep;53(9):499-517. (PMID: 29659381) Chemistry. 2000 Feb 18;6(4):719-24. (PMID: 10807182) Radiat Med. 2005 Aug;23(5):322-6. (PMID: 16342903) Brain Dev. 2016 Mar;38(3):331-6. (PMID: 26345358) |
| معلومات مُعتمدة: | R01 HD090191 United States HD NICHD NIH HHS; R01 ES027584 United States ES NIEHS NIH HHS; R01 AG061028 United States AG NIA NIH HHS; P30 AG072978 United States AG NIA NIH HHS; UH3 OD023348 United States OD NIH HHS; R03 AG063250 United States AG NIA NIH HHS; U54 NS115266 United States NS NINDS NIH HHS; R01 OH011511 United States OH NIOSH CDC HHS; R01 AG062348 United States AG NIA NIH HHS; U01 NS093334 United States NS NINDS NIH HHS; P30 HD018655 United States HD NICHD NIH HHS; U01 NS040069 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 84F6U3J2R6 (gadodiamide) 1BJ477IO2L (gadobutrol) AU0V1LM3JT (Gadolinium) K2I13DR72L (Gadolinium DTPA) 0 (Organometallic Compounds) 0 (Contrast Media) 6HG8UB2MUY (Meglumine) |
| تواريخ الأحداث: | Date Created: 20220920 Date Completed: 20221221 Latest Revision: 20240102 |
| رمز التحديث: | 20240102 |
| مُعرف محوري في PubMed: | PMC9792715 |
| DOI: | 10.1148/radiol.212171 |
| PMID: | 36125373 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1527-1315 |
|---|---|
| DOI: | 10.1148/radiol.212171 |