دورية أكاديمية
Reduction in Risk of Death Among Patients Admitted With COVID-19 Between the First and Second Epidemic Waves in New York City.
| العنوان: | Reduction in Risk of Death Among Patients Admitted With COVID-19 Between the First and Second Epidemic Waves in New York City. |
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| المؤلفون: | Bowen A; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Zucker J; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Shen Y; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Huang S; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Yan Q; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Annavajhala MK; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Kuhn L; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Sobieszczyk M; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA., Castor D; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, USA. |
| المصدر: | Open forum infectious diseases [Open Forum Infect Dis] 2022 Aug 25; Vol. 9 (9), pp. ofac436. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| مستخلص: | Background: Many regions have experienced successive epidemic waves of coronavirus disease 2019 (COVID-19) since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with heterogeneous differences in mortality. Elucidating factors differentially associated with mortality between epidemic waves may inform clinical and public health strategies. Methods: We examined clinical and demographic data among patients admitted with COVID-19 during the first (March-August 2020) and second (August 2020-March 2021) epidemic waves at an academic medical center in New York City. Results: Hospitalized patients (n = 4631) had lower overall and 30-day in-hospital mortality, defined as death or discharge to hospice, during the second wave (14% and 11%) than the first (22% and 21%). The wave 2 in-hospital mortality decrease persisted after adjusting for several potential confounders. Adjusting for the volume of COVID-19 admissions, a measure of health system strain, accounted for the mortality difference between waves. Several demographic and clinical patient factors were associated with an increased risk of mortality independent of wave: SARS-CoV-2 cycle threshold, do-not-intubate status, oxygen requirement, and intensive care unit admission. Conclusions: This work suggests that the increased in-hospital mortality rates observed during the first epidemic wave were partly due to strain on hospital resources. Preparations for future epidemics should prioritize evidence-based patient risks, treatment paradigms, and approaches to augment hospital capacity. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| التعليقات: | Update of: medRxiv. 2022 Mar 30;:. (PMID: 35378759) |
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| معلومات مُعتمدة: | K23 AI150378 United States AI NIAID NIH HHS; T32 AI100852 United States AI NIAID NIH HHS; U01 AI069470 United States AI NIAID NIH HHS; UM1 AI069470 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: COVID-19; Cox regression; epidemics; mortality |
| تواريخ الأحداث: | Date Created: 20220922 Latest Revision: 20230614 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9452151 |
| DOI: | 10.1093/ofid/ofac436 |
| PMID: | 36131846 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2328-8957 |
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| DOI: | 10.1093/ofid/ofac436 |