دورية أكاديمية

Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer.

التفاصيل البيبلوغرافية
العنوان: Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer.
المؤلفون: de Lima CSA; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Varca JPRO; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Alves VM; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Nogueira KM; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Cruz CPC; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Rial-Hermida MI; I+D Farma Group (GI-1645), Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Kadłubowski SS; Institute of Applied Radiation Chemistry (IARC), Lodz University of Technology, Wroblewskiego No. 15, 93-590 Lodz, Poland., Varca GHC; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil., Lugão AB; Nuclear and Energy Research Institute, IPEN-CNEN/SP-University of São Paulo, Av. Prof. Lineu Prestes, No. 2242, Cidade Universitária, São Paulo 05508-000, Brazil.
المصدر: Gels (Basel, Switzerland) [Gels] 2022 Sep 15; Vol. 8 (9). Date of Electronic Publication: 2022 Sep 15.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101696925 Publication Model: Electronic Cited Medium: Internet ISSN: 2310-2861 (Electronic) Linking ISSN: 23102861 NLM ISO Abbreviation: Gels Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: Bladder cancer (BC) is the tenth most common type of cancer worldwide, affecting up to four times more men than women. Depending on the stage of the tumor, different therapy protocols are applied. Non-muscle-invasive cancer englobes around 70% of the cases and is usually treated using the transurethral resection of bladder tumor (TURBIT) followed by the instillation of chemotherapy or immunotherapy. However, due to bladder anatomy and physiology, current intravesical therapies present limitations concerning permeation and time of residence. Furthermore, they require several frequent catheter insertions with a reduced interval between doses, which is highly demotivating for the patient. This scenario has encouraged several pieces of research focusing on the development of drug delivery systems (DDS) to improve drug time residence, permeation capacity, and target release. In this review, the current situation of BC is described concerning the disease and available treatments, followed by a report on the main DDS developed in the past few years, focusing on those based on mucoadhesive polymers as a strategy. A brief review of methods to evaluate mucoadhesion properties is also presented; lastly, different polymers suitable for this application are discussed.
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معلومات مُعتمدة: 2021/09636-1 São Paulo Research Foundation; 2019/01315-1 São Paulo Research Foundation; 2017/50332-0 São Paulo Research Foundation; ED481B 2018/009 Xunta de Galicia
فهرسة مساهمة: Keywords: bladder tumor; drug release; intravesical therapy; mucoadhesion; polymeric hydrogels
تواريخ الأحداث: Date Created: 20220922 Latest Revision: 20220924
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9498303
DOI: 10.3390/gels8090587
PMID: 36135300
قاعدة البيانات: MEDLINE
الوصف
تدمد:2310-2861
DOI:10.3390/gels8090587